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| Creator | Title | Description | Subject | Date | ||
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Albert Lasker Awards Ceremony, 2001 | This is the 1 hour, 45 minutes, and 41 seconds video of the Lasker Awards Ceremony and Banquet held in September, 2001. The Albert Lasker Award for Basic Medical Research was given to Mario R. Capecchi, Oliver Smithies, and Martin Evans for their work in genetic research. Martin Evans discovered h... | Capecchi, Mario R.; Gene targeting; Embryonic stem cells; Transgenic mice; Genetic engineering; Science - Awards - United States; Smithies, Oliver; Evans, Martin J.; Awards presentations | 2001 | |
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Couldwell, William T. | Astrocytoma cell line | TO THE EDITOR: It has long been established clinically that patients with neurofibromatosis Type 1 (NF1) have an increased susceptibility to develop many central and peripheral tumors. The nature of the genetic alterations underlying NF1 have recently begun to be characterized. It has been demo... | 2001 | |
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Baehr, Wolfgang | Calcium-sensitive regions of GCAP1 as observed by chemical modifications, fluorescence, and EPR spectroscopies | Guanylyl cyclase-activating proteins are EF-hand Ca(2+)-binding proteins that belong to the calmodulin superfamily. They are involved in the regulation of photoreceptor membrane-associated guanylyl cyclases that produce cGMP, a second messenger of vertebrate vision. Here, we investigated changes in ... | Amino Acid Motifs; Cyclic N-Oxides; EF Hand Motifs | 2001 |
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Baehr, Wolfgang; Zhang, Kang | Characterization of human GRK7 as a potential cone opsin kinase | PURPOSE: Homozygous inactivation of the mouse gene for GRK1 (G protein-coupled receptor kinase 1, or rhodopsin kinase) causes severe defects in the recovery of cone phototransduction. However, electroretinographic (ERG) analyses of human oguchi patients with defective GRK1 alleles showed normal or s... | Amino Acid Sequence; Chromosomes, Human, Pair 3; Fluorescent Antibody Technique, Indirect | 2001 |
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Bernstein, Paul S.; Zabriskie, Norman A.; Zhang, Kang; Leppert, Mark F. | Diverse macular dystrophy phenotype caused by a novel complex mutation in the ELOVL4 gene | PURPOSE: A 5-bp deletion in ELOVL4, a photoreceptor-specific gene, has been associated with autosomal dominant (ad) macular dystrophy phenotypes in five related families, in which phenotypes range from Stargardt-like macular dystrophy (STGD3; Mendelian Inheritance in Man 600110) to pattern dystrophy... | Linkage (Genetics); Middle Older people; Phenotype | 2001 |
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Dailey, Andrew T.; Brodke, Darrel S. | Dynamic cervical plates: biomechanical evaluation of load sharing and stiffness | Study Design. An in vitro biomechanical study using a simulated cervical corpectomy model to compare the load-sharing properties and stiffnesses of two static and two dynamic cervical plates. Objectives. To evaluate the load-sharing properties of the instrumentation with a full-length graft and... | In vitro biomechanical study; Cervical corpectomy; Cervical plates | 2001 |
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Couldwell, William T. | Effect of absorbable topical hemostatic agents on the relaxation time of blood: an in vitro study with implications for postoperative magnetic resonance imaging | Absorbable topical hemostatic agents are commonly used in neurosurgery. In this study the authors examine the longitudinal relaxation time (T1) of blood in contact with these agents over time, measured in vitro, to determine if their presence could affect the interpretation of postoperative magneti... | Absorbable hemostatic agent; Collastat; Surgicel; Oxidized regenerated cellulose; Methemoglobin | 2001 |
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Bernstein, Paul S. | Evaluation of the G protein coupled receptor-75 (GPR75) in age related macular degeneration | 2001 | ||
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Couldwell, William T. | Glioma invasion | A characteristic pathological feature of malignant glioma cells is their ability to extensively invade surrounding brain parenchyma-particularly along white matter tracts- thus rendering focal therapies incapable of controlling tumor growth and resulting in inevitable recurrence. In this regard, ... | 2001 | |
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Couldwell, William T. | History and evolution of transsphenoidal surgery | Initial attempts at transcranial approaches to the pituitary gland in the late 1800s and early 1900s resulted in a mortality rate that was generally considered prohibitive. Schloffer suggested the use of a transsphenoidal route as a safer, alternative approach to the sella turcica. He reported the f... | Neurosurgical history; Transsphenoidal surgery; Pituitary tumor | 2001 |
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Zhang, Kang | Identification and functional consequences of a new mutation (E155G) in the gene for GCAP1 that causes autosomal dominant cone dystrophy | 2001 | ||
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Couldwell, William T. | Irving S. Cooper and the early surgical management of movement disorders | Irving S. Cooper was a pioneer in the field of functional neurosurgery. During his very productive and controversial career, he proposed the surgical treatment of Parkinson disease (PD) by ligating the anterior choroidal artery to control tremor and rigidity. Subsequently, he developed seminal techn... | Functional neurosurgery; Movement disorder; Video | 2001 |
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Couldwell, William T. | No ordinary time, no ordinary men: the relationship between Harvey Cushing and Franklin D. Roosevelt, 1928-1939 | The authors elucidate the strong personal relationship that developed between Dr. Harvey Cushing and Franklin Delano Roosevelt (FDR) from 1928 to 1939, as manifested in their frequent letters to each other. The relationship was initiated by the marriage of their children. Through his correspondence ... | 2001 | |
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Kestle, John R. W. | Predicting shunt failure on the basis of clinical symptoms and signs in children | Object. In evaluating pediatric patients for shunt malfunction, predictive values for symptoms and signs are important in deciding which patients should undergo an imaging study, whereas determining clinical findings that correlate with a low probability of shunt failure could simplify management. ... | Pediatric Shunt Design Trial; PSDT; Shunt failure; Shunt malfunction; Clinical signs | 2001 |
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Couldwell, William T. | Use of cylindrical titanium mesh and locking plates in anterior cervical fusion | After performing anterior cervical corpectomy or discectomy for cervical spondolytic myelopathy or radiculopathy, iliac crest bone graft and fibular auto- or allograft is often used to achieve arthrodesis in the cervical spine. The purpose of this study was to evaluate the use of a cylindrical titan... | Anterior cervical fusion; Arthrodesis; Cylindrical titanium mesh; Lordosis; Kyphosis | 2001 |
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Dailey, Andrew T.; Moore, Kevin R. | Value of MR neurography for evaluating extraspinal neuropathic leg pain: a pictorial essay | Summary: Fifteen patients with neuropathic leg pain referable to the lumbosacral plexus or sciatic nerve underwent high-resolution MR neurography. Thirteen of the patients also underwent routine MR imaging of the lumbar segments of the spinal cord before undergoing MR neurography. Using phased-array... | MR neurography; Neuropathic leg pain; Extraspinal; Lumbosacral plexus | 2001 |
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Caserta, Michael; Lund, Dale A. | When the unexpected happens: husbands coping with the deaths of their wives | Most husbands do not outlive their wives. The 1990 Census of the United States reveals that while nearly 49 percent of women are widowed after age sixty-five only 14 percent of the men are widowed. After age eighty-five the rates of widowhood increase for both men and women. About 80 percent of thes... | 2001 |
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