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CreatorTitleDescriptionSubjectDate
1 Borodai, Anastasia S.C-F bond activationActivation of Carbon-Fluorine Bonds in 2', 3', 4', 5', 6'-Pentafluoroacetophenone through a Transition Metal Complex- Manganese PentacarbonylCarbon; Fluorine; Bond; Activation2014-05-30
2 Jorgensen, Erik; Schuske, Kimberly R.CAPS and syntaxin dock dense core vesicles to the plasma membrane in neuronsDocking to the plasma membrane prepares vesicles for rapid release. Here, we describe a mechanism for dense core vesicle docking in neurons. In Caenorhabditis elegons motor neurons, dense core vesicles dock at the plasma membrane but are excluded from active zones at synapses.2008
3 Bohs, Lynn A.Phylogenetic relationships in Solanum (Solanaceae) based on ndhF sequencesA phylogenetic analysis was conducted using sequence data from the chloroplast gene ndhF. Sequences were obtained from 25 species of Solanaceae, including 18 species of Solanum representing five of the seven conventionally recognized subgenera.Solanum; ndhF1997
4 Miller, Joel StevenPreparation and characterization of square-planar tetrakis(cyanoacetylide) complexes: [MII(C=C-C=N)4]2- (M = Ni,Pd, Pt)Complexes [MII(C=C-=N)4]2 - (M = Ni, Pd, Pt) are prepared for the first time and the structure of [NEt4]2[Ni(C=C-C=N)4] is determined to have a square-planar geometryBonding; Structure; Ligand1996
5 Mattis, Daniel C.Existence of two phase transitions in Hubbard modelWe solve the Hubbard model, for one electron per atom in a simple cubic structure, using one-particle Green's functions. We determine the accuracy of this calculation to be good by comparison with an exact solution by Lieb and Wu of a one-dimensional limiting case.Critical temperature1969-12
6 Jorgensen, ErikOpen syntaxin docks synaptic vesiclesSynaptic vesicles dock to the plasma membrane at synapses to facilitate rapid exocytosis. Docking was originally proposed to require the soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE) proteins; however, perturbation studies suggested that docking was independent of the...2007
7 Jorgensen, ErikMutations in β-spectrin disrupt axon outgrowth and sarcomere structureB-Spectrin is a major component of the membrane skeleton, a structure found at the plasma membrane of most animal cells. B-Spectrin and the membrane skeleton have been proposed to stabilize cell membranes, generate cell polarity, or localize specific membrane proteins. We demonstrate that the Caen...2000
8 Bohs, Lynn A.Phylogenetic relationships among the "spiny solanums" (Solanum subgenus Leptostemonum, Solanaceae)Species of Solanum subgenus Leptostemonum comprise almost one third of the genus and are distributed worldwide. Members of this group are defined by their sharp epidermal prickles; thus, they are commonly referred to as the ˜spiny solanums." This subgenus includes a number of economically important...Granule-bound starch synthase gene; GBSSI; Heterandry; ITS; Leptostemonum; Solanum; trnS-trnG; Waxy2006
9 Jorgensen, ErikTrio's Rho-specific GEF domain is the missing Gaq effector in C. elegansThe Gaq pathway is essential for animal life and is a central pathway for driving locomotion, egg laying, and growth in Caenorhcibditis elegans, where it exerts its effects through EGL-8 (phospholipase CB [PLCB]) and at least one other effector. To find the missing effector, we performed forward ...2007-11-01
10 Jorgensen, Erikμ2 adaptin facilitates but is not essential for synaptic vesicle recycling in Caenorhabditis elegansSynaptic vesicles must be recycled to sustain neurotransmission, in large part via clathrin-mediated endocytosis. Clathrin is recruited to endocytic sites on the plasma membrane by the AP2 adaptor complex. The medium subunit (u 2) of AP2 binds to cargo proteins and phosphatidylinositol-4,5-bisph...Synaptic vesicles; Caenorhabditis elegans; Adaptin2008
11 Bohs, Lynn A.Four-gene study of evolutionary relationships in Solanum section AcanthophoraThe "spiny solanums," Solanum subgenus Leptostemonum (Solanaceae), comprise a large lineage with over 350 species and include the cultivated eggplant, Solanum melongena. Despite the importance of this subgenus, phylogenetic relationships among these taxa are currently unclear. The present research...Acanthophora; Granule-bound starch synthase gene; GBSSI; ITS; Internal transcribed spacer; Solanum; trnS-trnG; trnT-trnF; Waxy2005
12 Capecchi, Mario R.Hoxb8 is required for normal grooming behavior in mice.Repertoires of grooming behaviors critical to survival are exhibited by most animal species, including humans. Genes that influence this complex behavior are unknown. We report that mice with disruptions of Hoxb8 show, with 100% penetrance, excessive grooming leading to hair removal and lesions. Add...Aging; Alleles; Animals, Newborn; Behavior, Animal; Bone and Bones; Disease Models, Animal; Mice, Knockout Nerve Net2002-01-03
13 Adler, Frederick R.; Liou, Theodore G.; Cahill, Barbara C.Selection of patients with cystic fibrosis for lung transplantationLung transplantation is the most aggressive therapy available for end-stage lung disease from cystic fibrosis (CF). A new predictive survival model of CF uses demographic, FEV1, nutritional, microbiologic, and acute exacerbation data to produce precise estimates of 5-year survival.Predicted survival; Living donor; Mechanical ventilation2002
14 Beckerle, Mary C.Identification of a new protein localized at sites of cell-substrate adhesionA new protein found at sites of cellsubstrate adhesion has been identified by analysis of a nonimmune rabbit serum. By indirect immunofluorescence this serum stains focal contacts (adhesion plaques) and the associated termini of actin filament bundles in cultured chicken cells.Actin; Nonimmune rabbit serum; Polypeptide1986
15 Bohs, Lynn A.Phylogeny of the carolinense clade of solanum (Solanaceae) inferred from nuclear and plastid DNA sequencesThe large and economically important genus Solanum contains ca. 1,400 species distributed worldwide. One of the 12-14 major clades identified in the genus is the Leptostemonum clade, or the "spiny solanums." Previous molecular phylogenetic studies have identified 14 major clades in the spiny solanum...2014-01-01
16 Crespo, Jose GuillermoA review of chemosensation and related behavior in aquatic insectsInsects that are secondarily adapted to aquatic environments are able to sense odors from a diverse array of sources. The antenna of these insects, as in all insects, is the main chemosensory structure and its input to the brain allows for integration of sensory information that ultimately ends in b...2011-09-13
17 Beckerle, Mary C.ALP-enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegansMutations that affect the Z-disk-associated ALP-Enigma proteins have been linked to human muscular and cardiac diseases. Despite their clear physiological significance for human health, the mechanism of action of ALP-Enigma proteins is largely unknown. In Caenorhabditis elegans, the ALP-Enigma prot...Actin; Caenorhabditis elegans; Contractility; alp-1 mutants; Z-disks; Kettin2009
18 Carrier, David R.Functional tradeoffs in specialization for fighting versus runningBoth locomotion and fighting are critical to survival and reproductive fitness in many vertebrate species. Yet, characters that make an individual good at fighting may, in many cases, limit locomotor performance and vice versa. Here I describe tests of three functional tradeoffs in the limb muscles ...Greyhounds; Pit Bulls; Australopithecus; Homo; Fighting; Running; Male-male aggression; Limb muscles; Functional tradeoff2002
19 Beckerle, Mary C.Molecular dissection of a LIM domainLIM domains are novel sequence elements that are found in more than 60 gene products, many of which function as key regulators of developmental pathways. The LIM domain, characterized by the cysteine-rich consensus CX2CX16_23HX2CX2CX2CX16_21CX2-3(C/H/ D), is a specific metal-binding structure tha...LIM domains; Metal-binding; Zyxin; Cysteine-rich proteins1997
20 Beckerle, Mary C.Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeletonLIM domains are present in a number of proteins including transcription factors, a protooncogene product, and the adhesion plaque protein zyxin. The LIM domain exhibits a characteristic arrangement of cysteine and histidine residues and represents a novel zinc binding sequence (Michelsen et al., ...Zyxin; Cysteine-rich proteins; cCRP; Actin; LIM domains1994
21 Beckerle, Mary C.Interaction between zyxin and α-actininZyxin is an 82-kD protein first identified as a component of adhesion plaques and the termini of stress fibers near where they associate with the cytoplasmic face of the adhesive membrane. We report here that zyxin interacts with the actin cross-linking protein α-actinin.Zyxin; Actinin; Actin1992
22 Ailion, David Charles; Morris, Alan H.Determination of lung water content and distribution by nuclear magnetic resonance imagingNMR imaging techniques are applicable to the assessment of lung water content and distribution because the NMR signal is, under certain conditions, proportional to tissue proton density. NMR imaging is noninvasive, easily repeatable, free from ionizing radiation, and particularly suitable for the as...Water content1986
23 Jorgensen, ErikUNC-11, a Caenorhabditis elegans AP180 homologue, regulates the size and protein composition of synaptic vesiclesThe unc-11 gene of Caenorhabditis elegans encodes multiple isoforms of a protein homologous to the mammalian brain-specific clathrin-adaptor protein AP180. The UNC-11 protein is expressed at high levels in the nervous system and at lower levels in other tissues. In neurons, UNC-11 is enriched at pr...Caenorhabditis elegans; Synaptic vesicles; unc-11; Synaptobrevin; Endocytosis1999
24 Jorgensen, ErikAxon regeneration genes identified by RNAi screening in C. elegansAxons of the mammalian CNS lose the ability to regenerate soon after development due to both an inhibitory CNS environment and the loss of cell-intrinsic factors necessary for regeneration. The complex molecular events required for robust regeneration of mature neurons are not fully understood, part...2014-01-01
25 Olivera, Baldomero M.P-superfamily conopeptidesThe present invention is directed to P-superfamily conopeptides, to DNA encoding precursors of the P-superfamily conopeptides and to the precursor peptides.2006
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