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1 Olivera, Baldomero M.Novel venom peptides from the cone snail Conus pulicarius discovered through next-generation sequencing of its venom duct transcriptomeThe venom peptides (i.e., conotoxins or conopeptides) that species in the genus Conus collectively produce are remarkably diverse, estimated to be around 50,000 to 140,000, but the pace of discovery and characterization of these peptides have been rather slow. To date, only a minor fraction have be...2012
2 Voth, Gregory Alan; Ayton, Gary S.Role of protein interactions in defining HIV-1 viral capsid shape and stability: a coarse-grained analysisCoarse-grained models of the HIV-1 CA dimer are constructed based on all-atom molecular dynamics simulations. Coarse-grained representations of the capsid shell, which is composed of approximately 1,500 copies of CA proteins, are constructed and their stability is examined. A key interaction between...Virus capsid; HIV-1; Viral capsid shape; Coarse-graining; CA dimer2010-01
3 Olivera, Baldomero M.Identification of Conus peptidylprolyl cis-trans isomerases (PPIases) and assessment of their role in the oxidative folding of conotoxinsPeptidylprolyl cis-trans isomerases (PPIases) are ubiquitous proteins that catalyze the cis-trans isomerization of prolines. A number of proteins, such as Drosophila rhodopsin and the human immunodeficiency viral protein HIV-1 Gag, have been identified as endogenous substrates for PPIases. However, ...2010
4 Olivera, Baldomero M.Biochemical characterization of ?M-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of ?M-conotoxinsConus snail (Conus) venoms are a valuable source of pharmacologically active compounds; some of the peptide toxin families from the snail venoms are known to interact with potassium channels. We report the purification, synthesis, and characterization of ?M-conotoxin RIIIJ from the venom of a fish-...2010
5 Coley, Phyllis D.On turning green into goldAnthropogenic effects on the climate and biodiversity of our planet are among the most troubling and perhaps irreversible threats facing scientists, policymakers, and citizens. Yet many scientists are reluctant or unsure of how to apply their expertise in basic science to these pressing real-world p...Bioprospecting; Drug discovery; Active compounds; Panama2008
6 Sekercioglu, CaganIbis questThe day I arrived in Ethiopia, researcher Yilma Dellelegn Abebe of the Ethiopia Wildlife and Natural History Society (EWNHS) was just leaving the capital city, Addis Ababa, to search for three Northern Bald Ibises in a remote, roadless area of the country. These critically endangered birds had been ...2007-01-01
7 Olivera, Baldomero M.; Bulaj, GrzegorzNovel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptorsWe report the discovery and characterization of three conantokin peptides from the venom of Conus parius. Each peptide (conantokin-Pr1, -Pr2, and -Pr3) contains 19 amino acids with three γ-carboxyglutamate (Gla) residues, a post-translationally modified amino acid characteristic of conantokins. The...Conotoxins; Conantokins; Conus parius; Antagonists; n-methyl-D-aspartate receptors2007
8 Olivera, Baldomero M.Conus peptides: biodiversity-based discovery and exogenomicsThe venoms of the ~700 species of predatory cone snails (genus Conus) are being systematically characterized. Each Conus species contains 100-200 small, highly structured venom peptides (colloquially known as conotoxins), which are synthesized and secreted in a venom duct (for overviews, see Refs. ...Conotoxins; Conus peptides; Exogenomics2006
9 Olivera, Baldomero M.Uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptorWe have purified and characterized a novel conotoxin from the venom of Conus obscurus, which has the unique property of selectively and potently inhibiting the fetal form of the mammalian neuromuscular nicotinic acetylcholine receptor (nAChR) (α1β1γδ-subunits). Although this conotoxin, αA-cono...Conotoxins; Conus obscurus; Fetal; Muscle; nAChR; Inhibitor; Receptor2005-01-19
10 Coley, Phyllis D.; Kursar, Thomas A.Novel DNA-based microfluorimetric method to evaluate antimalarial drug activityThis paper describes the development of a novel microfluorimetric assay to measure the inhibition of Plasmodium falciparum based on the detection of parasitic DNA by intercalation with PicoGreen®. The method was used to determine parasite inhibition profiles and 50% inhibitory concentration values ...Microfluorimetric assay; Plasmodium falciparum; Chloroquine; Drug discovery2004
11 Coley, Phyllis D.; Kursar, Thomas A.Using ecological criteria to design plant collection strategies for drug discoveryTropical forests are one of the most diverse and endangered habitats on earth. They have also been portrayed as a source of future pharmaceuticals, yet finding useful compounds can be both scientifically and politically challenging. Increasingly, over the past decade, the potential value of medicina...Drug discovery; Biodiversity2003
12 Olivera, Baldomero M.Venomous gastropods: Conus, conoideans and other neogastropod familiesA review of the present understanding of the mechanism of envenomation by cones is presented. The expanding applications of cone snail venom components in biomedical science are the degree to which the envenomation strategy may be shared by other venomous gastropod groups is explored based on a prel...Venomous gastropods; Conoideans; Conotoxins; Envenomation; Toxoglossa2002
13 Miller, Joel StevenInnovation in crystal engineeringThe first CrystEngComm discussion meeting on crystal engineering has demonstrated that the field has reached maturity in some areas (for example: design strategies, characterization of solid compounds, topological analysis of weak and strong non-covalent interactions), while the quest for novel pro...Research; Design; Molecular2002
14 Capecchi, Mario R.Generating mice with targeted mutations.Mutational analysis is one of the most informative approaches available for the study of complex biological processes. It has been particularly successful in the analysis of the biology of bacteria, yeast, the nematode worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. Extension ...Animals; Recombination, Genetic; Stem Cells2001-10-01
15 Poulter, Charles DaleCaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificitiesMany proteins that contain a carboxyl-terminal CaaX sequence motif, including Ras and yeast a-factor, undergo a series of sequential posttranslational processing steps. Following the initial prenylation of the cysteine, the three C-terminal amino acids are proteolytically removed, and the newly fo...Proteins; Enzymes; Hydrophobic2000
16 Olivera, Baldomero M.; McIntosh, J. MichaelIsolation and characterization of a novel Conus peptide with apparent antinociceptive activityCone snails are tropical marine mollusks that envenomate prey with a complex mixture of neuropharmacologically active compounds. We report the discovery and biochemical characterization of a structurally unique peptide isolated from the venom of Conus marmoreus. The new peptide, mr10a, potently incr...Conotoxins; Conus peptides; Conus marmoreus; mr10a; antinociceptive activity2000
17 Capecchi, Mario R.Gene targeting: an historical perspectiveOur entry into what was going to become the field of gene targeting began in 1977. I was experimenting with the use of extremely small glass needles to inject DNA directly into the nuclei of living cells. The needles were controlled by hydraulically driven micro-manipulators and were directed into n...Gene targeting -- History; Homologous recombination1998
18 Olivera, Baldomero M.; Gray, William Robert; McIntosh, J. MichaelDifferential targeting of nicotinic acetylcholine receptors by novel αA-conotoxinsWe describe the isolation and characterization of two peptide toxins from Conus ermineus venom targeted to nicotinic acetylcholine receptors (nAChRs). The peptide structures have been confirmed by mass spectrometry and chemical synthesis. In contrast to the 12-18 residue, 4 Cys-containing α-co...Conotoxins; aA-conotoxins; Conus ermineus; Peptide toxins1997
19 Olivera, Baldomero M.Conus venom peptides, receptor and ion channel targets, and drug design: 50 million years of neuropharmacologyThe predatory cone snails (Conus) are among the most successful living marine animals (~500 living species). Each Conus species is a specialist in neuropharmacology, and uses venom to capture prey, to escape from and defend against predators and possibly to deter competitors. An individual cone...Conotoxins1997
20 Capecchi, Mario R.Personal view of gene targetingGene targeting provides the means for creating strains of mice with mutations in virtually any gene.1 First, the desired mutation is introduced into a cloned copy of the chosen gene by standard recombinant DNA technology. The mutation is then transferred to the genome of a pluripotent mouse embryo-d...1995
21 Olivera, Baldomero M.; McIntosh, J. MichaelConus peptides as tools for the neuroscientistRecombinant DNA technology has had a powerful impact on understanding receptors and ion channels, the key components in the nervous system that are involved in intercellular communication. Cloning genes encoding these proteins has revealed that for every receptor and ion channel type, multiple molec...Conus peptides; Conotoxins1993
22 Olivera, Baldomero M.DNA-topoisomerase modificationThe first reports of topoisomerase modification were published in 1982 and 1983 (Mills et al. 1982; Durban et al. 1983; Ferro et al. 1983; Jongstra-Bilen et al. 1983). Although a wide variety of posttranslational modifications of DNA topoisomerases may occur, this chapter focuses only on phosphoryl...Poly(ADP-ribosylation); Serine residues1990
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