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Creator | Title | Description | Subject | Date |
| 76 |
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Capecchi, Mario R. | Housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland. | Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in purine catabolism occurring in most cell types. However, this housekeeping gene is expressed at very high levels in a number of mammalian tissues including the lactating mammary epithelium, suggesting additional roles for XOR in these tiss... | Body Weight; Cell Differentiation; Cell Membrane; Epithelium | 2002-12-15 |
| 77 |
 |
Jorgensen, Erik | Neural plasticity | Neural plasticity refers to functional changes in the nervous system and therefore encompasses a range of phenomena from changes at synapses observed on a microscopic scale to changes in behavior observed in the whole animal. These diverse phenomena are related since changes in synapses are believ... | Synapses; Nervous System; Development | 1997 |
| 78 |
 |
Jorgensen, Erik | Genetic screens for synaptic function mutants in the nematode C. elegans | The synapse is the site of a remarkable conversion of electrical signals into chemical signals. This conversion takes place when a depolarizing impulse enters the axon terminal and opens voltage-sensitive calcium channels; calcium then flows into the cell and initiates the fusion of synaptic vesicle... | Vesicle; Neurotransmission; Cell | 1996 |
| 79 |
 |
Williams, Clayton C. | Instability induced tunneling and repeatable charge injection to SiO2 surfaces by electrostatic force microscopy | The dynamic response and stability of a voltage biased oscillating cantilever in the proximity of an insulating sample surface is investigated. As the tip approaches the sample surface, the cantilever can jump between two different oscillation modes. The jump is detected as an abrupt increase in t... | Electrostatic force microscopy; EFM; Dielectric films | 2004 |
| 80 |
 |
Capecchi, Mario R. | Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. | Although the role of Hox genes in patterning the mammalian body plan has been studied extensively during embryonic and fetal development, relatively little is known concerning Hox gene function in adult animals. Analysis of mice with mutant Hoxa9, Hoxb9, and Hoxd9 genes shows that these paralogous g... | Embryonic and Fetal Development; Gene Expression Regulation, Developmental; Genotype; Mice, Knockout | 1999-01 |
| 81 |
 |
Capecchi, Mario R. | Selective degradation of abnormal proteins in mammalian tissue culture cells. | The degradation rates of several missense mutants of hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) in mouse L cells are compared to those of the wild-type enzyme. Although the rates of total protein breakdown in the mutant cell lines are identical to that of the parental L cell line, ... | Gene Expression Regulation; Mice, Transgenic; Microscopy, Fluorescence | 1974-12-01 |
| 82 |
 |
Coley, Phyllis D.; Kursar, Thomas A. | Effects of weather on fungal abundance and richness among 25 communities in the Intermountain West | Because moisture and temperature influence the growth of fungi, characterizing weather conditions favorable for fungi may be used to predict the abundance and richness of fungi in habitats with different climate conditions. To estimate habitat favorability to fungi, we examined the relationship of f... | Intermountain West; Utah; Microclimate; Fungal prevalence | 2002 |
| 83 |
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Coley, Phyllis D.; Kursar, Thomas A. | Using ecological criteria to design plant collection strategies for drug discovery | Tropical forests are one of the most diverse and endangered habitats on earth. They have also been portrayed as a source of future pharmaceuticals, yet finding useful compounds can be both scientifically and politically challenging. Increasingly, over the past decade, the potential value of medicina... | Drug discovery; Biodiversity | 2003 |
| 84 |
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Hultine, Kevin; Bush, Sarah Elizabeth; Ehleringer, James R. | Effect of gender on sap-flux-scaled transpiration in a dominant riparian tree species: Box elder (Acer negundo) | Acer negundo is a dioecious riparian tree species with a spatial segregation of the sexes along soil moisture gradients. Females are typically more common in wet sites along streams (typically F/M = 1.6), whereas males are more common in drier sites away from streams (typically F/M = 0.6). Spatial s... | Density; Ecosystem; Segregation | 2007 |
| 85 |
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Williams, Clayton C. | Single electron tunneling to insulator surfaces detected by electrostatic force | The detection of single-electron tunneling events between a metallic scanning probe tip and an insulating surface is demonstrated by an electrostatic force method. When a voltage-biased oscillating atomic force microscopy tip is placed within tunneling range of the surface of an insulator, single... | Single electron; Tunneling events; Scanning tunneling microscope | 2002 |
| 86 |
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Capecchi, Mario R. | Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. | hoxb-5 and hoxb-6 are adjacent genes in the mouse HoxB locus and are members of the homeotic transcription factor complex that governs establishment of the mammalian body plan. To determine the roles of these genes during development, we generated mice with a targeted disruption in each gene. Three ... | Alleles; CCAAT-Enhancer-Binding Proteins; Cervical Vertebrae; DNA-Binding Proteins; Forelimb; Genetic Complementation Test | 1995-01-01 |
| 87 |
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Ehleringer, James R.; Belnap, Jayne | Sensitivity of the Colorado plateau to change: climate, ecosystems, and society | The Colorado Plateau is located in the interior, dry end of two moisture trajectories coming from opposite directions, which have made this region a target for unusual climate fluctuations. A multidecadal drought event some 850 years ago may have eliminated maize cultivation by the first human settl... | Colorado Plateau; Biological crust; Climate change; Megadrought; Ranching; Dry crop productivity; Extractive industries; Pueblo Indians; Fremont culture | 2008 |
| 88 |
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Capecchi, Mario R. | Hox11 paralogous genes are essential for metanephric kidney induction | The mammalian Hox complex is divided into four linkage groups containing 13 sets of paralogous genes. These paralogous genes have retained functional redundancy during evolution. For this reason, loss of only one or two Hox genes within a paralogous group often results in incompletely penetrant phen... | Metanephric; Six2; Wt1 | 2002-06-01 |
| 89 |
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Jorgensen, Erik | Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles | Rab molecules regulate vesicular trafficking in many different exocytic and endocytic transport pathways in eukaryotic cells. In neurons, rab3 has been proposed to play a crucial role in regulating synaptic vesicle release. To elucidate the role of rab3 in synaptic transmission, we isolated and cha... | | 1997 |
| 90 |
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Gesteland, Raymond F.; Atkins, John F. | Frameshifting in gene 10 of bacteriophage T7 | Gene 10 of bacteriophage T7, which encodes the most abundant capsid protein, has two products: a major product, 10A (36 kDa), and a minor product, 10B (41 kDa). 10B is produced by frameshifting into the -1 frame near the end of the 10A coding frame and is incorporated into the capsid. The frameshift... | Frameshifting; Bacteriophage T7; RNA, Viral; Gene Expression | 1991 |
| 91 |
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Jorgensen, Erik | Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor | Ionotropic GABA receptors generally require the products of three subunit genes. By contrast, the GABA receptor needed for locomotion in Caenorhabditis elegans requires only the unc-49 gene. We cloned unc-49 and demonstrated that it possesses an unusual overlapping gene structure. | | 1999 |
| 92 |
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Capecchi, Mario R. | Generating mice with targeted mutations. | Mutational analysis is one of the most informative approaches available for the study of complex biological processes. It has been particularly successful in the analysis of the biology of bacteria, yeast, the nematode worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. Extension ... | Animals; Recombination, Genetic; Stem Cells | 2001-10-01 |
| 93 |
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Capecchi, Mario R. | Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA. | Biochemical transformation of thymidine-kinase-deficient (TK-) mouse L cells is enhanced 20 to 40 fold when microinjected plasmid DNA contains regions of the genomes of Rous sarcoma virus or simian virus 40 in addition to the complete herpes simplex virus tk gene, irrespective of the orientation and... | Animals; Base Sequence; Genes, Viral; Plasmids; Thymidine Kinase | 1983-07-01 |
| 94 |
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Vardeny, Zeev Valentine | Fabrication and properties of gallium metallic photonic crystals | Gallium metallic photonic crystals with 100% filling factor have been fabricated via infiltration of liquid gallium into opals of 300-nm silica spheres using a novel high pressure-high temperature technique. The electrical resistance of the Ga-opal crystals was measured at temperatures from 10 to 2... | | 2003-10 |
| 95 |
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Wu, Yong-Shi | Wave function describing superfluidity in a perfect crystal | We propose a many-body wave function that exhibits both diagonal and off-diagonal long-range order. Incorporating short-range correlations due to interatomic repulsion, this wave function is shown to allow condensation of zero-point lattice vibrations and phase rigidity. In the presence of an exter... | | 2005-07-01 |
| 96 |
 |
Capecchi, Mario R. | Hoxc13 mutant mice lack external hair | Hox genes are usually expressed temporally and spatially in a colinear manner with respect to their positions in the Hox complex. Consistent with the expected pattern for a paralogous group 13 member, early embryonic Hoxc13 expression is found in the nails and tail. Hoxc13 is also expressed in vibri... | Filiform papillae; Homozygotes; Paralogous | 1998-01-01 |
| 97 |
 |
Williams, Clayton C.; Stringfellow, Gerald B. | Effect of substrate misorientation on ordering in Ga0.5In0.5P | Ordering produced in Gao.5Ino.5P epitaxial layers grown by OMVPE can be controlled by variations in the substrate misorientation as well as the growth temperature and the growth rate. The ordering produced at a growth temperature of 620°C and a relatively low growth rate of 0.5 /μm/hr is found to ... | Ga0.5In0.5P; Epitaxial layers; Epitaxial growth; OMVPE | 1994 |
| 98 |
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Coffin, Cheryl M.; Capecchi, Mario R. | Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. | Alveolar rhabdomyosarcoma is an aggressive childhood muscle cancer for which outcomes are poor when the disease is advanced. Although well-developed mouse models exist for embryonal and pleomorphic rhabdomyosarcomas, neither a spontaneous nor a transgenic mouse model of alveolar rhabdomyosarcoma has... | Cell Differentiation; Forkhead Transcription Factors; Myogenic Regulatory Factors | 2004-11-01 |
| 99 |
 |
Jorgensen, Erik | Mutations in β-spectrin disrupt axon outgrowth and sarcomere structure | B-Spectrin is a major component of the membrane skeleton, a structure found at the plasma membrane of most animal cells. B-Spectrin and the membrane skeleton have been proposed to stabilize cell membranes, generate cell polarity, or localize specific membrane proteins. We demonstrate that the Caen... | | 2000 |
| 100 |
 |
Olivera, Baldomero M. | P-superfamily conopeptides | The present invention is directed to P-superfamily conopeptides, to DNA encoding precursors of the P-superfamily conopeptides and to the precursor peptides. | | 2006 |
