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CreatorTitleDescriptionSubjectDate
51 Ehleringer, James R.Population- and family-level variation of brittlebush (Encelia farinosa, Asteraceae) pubescence: its relation to drought and implications for selection in variable environmentsBecause leaf pubescence of the desert shrub Encelia farinosa increases in response to drought and influences photosynthesis and transpiration, we hypothesized that differences in water availability across the range of this species may result in genetic differentiation for pubescence and associated p...Encelia farinose; Absorptance; Adaptation; Asteraceae; Desert; Drought acclimation; Leaf pubescence; maternal family variance; spatiotemporal heterogeneity2003
52 Gesteland, Raymond F.; Atkins, John F.; Baranov, Pavel V.P-site tRNA is a crucial initiator of ribosomal frameshiftingThe expression of some genes requires a high proportion of ribosomes to shift at a specific site into one of the two alternative frames. This utilized frameshifting provides a unique tool for studying reading frame control. Peptidyl-tRNA slippage has been invoked to explain many cases of programmed ...Translation; Recoding; Kinetic Model; Frameshifting; Ribosome2004
53 Beckerle, Mary C.Two muscle-specific LIM proteins in DrosophilaThe LIM domain defines a zinc-binding motif found in a growing number of eukaryotic proteins that regulate cell growth and differentiation during development. Members of the cysteine-rich protein (CRP) family of LIM proteins have been implicated in muscle differentiation in vertebrates. Here we r...LIM domains; Mlp60A; Mlp84B; Cysteine-rich proteins1996
54 Poulter, Charles DaleIsopentenyl diphosphate:dimethylallyl diphosphate isomerase. An improved purification of the enzyme and isolation of the gene from Saccharomyces cerevisiae.Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase) is an enzyme in the isoprenoid biosynthetic pathway which catalyzes the interconversion of the primary five-carbon homoallylic and allylic diphosphate building blocks. We report a substantially improved procedure for purific...Amino Acid Sequence; Base Sequence; Chromatography, Gel; Chromatography, Ion Exchange1989-11-15
55 Poulter, Charles DaleLethal mutations in the isoprenoid pathway of salmonella entericaEssential isoprenoid compounds are synthesized using the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway in many gram-negative bacteria, some gram-positive bacteria, some apicomplexan parasites, and plant chloroplasts. The alternative mevalonate pathway is found in archaea and eukaryotes, includin...Isoprenoids; Mutation; Bacteria; Antimicrobials2006
56 Ehleringer, James R.Responses of boreal conifers to climate fluctuations: indications from tree-ring widths and carbon isotope analysesSpatial distribution and species composition of the boreal forest are expected to change under predicted climate change scenarios. Current research indicates that water limitations control the southern boundary of the central Canadian boreal forest and temperature limitations control the northern b...Boreal forests; Carbon budget; Picea mariana; Pinus banksiana; Carbon isotopes1998
57 Davidson, Diane W.Foraging ecology and community organization in desert seed-eating antsGranivorous ants in the southwestern deserts of the United States are characterized by species-specific colony foraging behaviors that determine their efficiencies at utilizing seeds from different density distributions. Workers search for food either in groups or as individuals, and these feedin...Ants; Arizona; California; Coexistence; Communities; Density specialization; Desert granivores; Foraging strategies; Insects; New Mexico; Resource partitioning1977
58 Hansen, Mark S.; Healy, Lindsey J.; Johnson, Christopher R.; Capecchi, Mario R.; Keller, Charles; Jones, Greg M.Virtual histology of transgenic mouse embryos for high-throughput phenotyping.A bold new effort to disrupt every gene in the mouse genome necessitates systematic, interdisciplinary approaches to analyzing patterning defects in the mouse embryo. We present a novel, rapid, and inexpensive method for obtaining high-resolution virtual histology for phenotypic assessment of mouse ...Forkhead Transcription Factors; Paired Box Transcription Factors2006
59 Olivera, Baldomero M.On a potential global role for vitamin K-dependent γ-carboxylation in animal systemsThe vitamin K-dependent γ-carboxylation of glutamate to γ-carboxyglutamate was originally well characterized in the mammalian blood clotting cascade. γ-Carboxyglutamate has also been found in a number of other mammalian proteins and in neuropeptides from the venoms of marine snails belonging to...Carboxylation; Glutamate; Carboxyglutamate; Carboxylase mRNA; Conantokin G2001
60 Beckerle, Mary C.ALP-enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegansMutations that affect the Z-disk-associated ALP-Enigma proteins have been linked to human muscular and cardiac diseases. Despite their clear physiological significance for human health, the mechanism of action of ALP-Enigma proteins is largely unknown. In Caenorhabditis elegans, the ALP-Enigma prot...Actin; Caenorhabditis elegans; Contractility; alp-1 mutants; Z-disks; Kettin2009
61 Thomas, Kirk R.; Capecchi, Mario R.Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian. cell nucleiWe have examined the mechanism of homologous recombination between plasmid molecules coinjected into cultured mammalian cells. Cell lines containing recombinant DNA molecules were obtained by selecting for the reconstruction of a functional Neor gene from two plasmids that bear different amber mutat...Animals; Cells, Cultured; DNA Restriction Enzymes; Kinetics1985-01
62 Ehleringer, James R.Water and nitrogen uptake patterns following moisture pulses in a cold desert communityVariation in the ability to utilize pulses of both water and nitrogen (N) is one possible mechanism allowing the coexistence of species in the cold desert community on the Colorado Plateau. We simulated 25-mm precipitation events and used stable isotope tracers (2H and 15N) to follow water and N upt...Colorado Plateau; Desert perennials; Nitrogen uptake patterns; Pulse utilization; Resource partitioning; Stable isotopes; Water uptake patterns2000
63 Gesteland, Raymond F.; Atkins, John F.; Wills, Norma M.rRNA-mRNA base pairing stimulates a programmed -1 ribosomal frameshiftBase pairing between the 3' end of 16S rRNA and mRNA is shown to be important for the programmed -1 frameshifting utilized in decoding the Escherichia coli dnaX gene. This pairing is the same as the Shine-Dalgarno pairing used by prokaryotic ribosomes in selection of translation initiators, but for ...Frameshifting; Escherichia coli; Binding Sites; Base Composition1994
64 Jorgensen, ErikTrio's Rho-specific GEF domain is the missing Gaq effector in C. elegansThe Gaq pathway is essential for animal life and is a central pathway for driving locomotion, egg laying, and growth in Caenorhcibditis elegans, where it exerts its effects through EGL-8 (phospholipase CB [PLCB]) and at least one other effector. To find the missing effector, we performed forward ...2007-11-01
65 Jorgensen, ErikUNC-11, a Caenorhabditis elegans AP180 homologue, regulates the size and protein composition of synaptic vesiclesThe unc-11 gene of Caenorhabditis elegans encodes multiple isoforms of a protein homologous to the mammalian brain-specific clathrin-adaptor protein AP180. The UNC-11 protein is expressed at high levels in the nervous system and at lower levels in other tissues. In neurons, UNC-11 is enriched at pr...Caenorhabditis elegans; Synaptic vesicles; unc-11; Synaptobrevin; Endocytosis1999
66 Olivera, Baldomero M.; Bandyopadhyay, Pradip K.Molecular phylogeny of some Indo-Pacific genera in the subfamily Turrinae H. Adams and A. Adams, 1853 (1838) (Gastropoda: Neogastropoda)We have carried out a phylogenetic analysis of a group of Indo-Pacific species in the subfamily Turrinae (Swainson, 1840) using 128 mitoehondrial ribosomal RNA gene sequcnces Most of the species analyzed are convenlionally assigned to one of there Lophiotoma Casey, 1904. The inolecular anaysis revea...Turrinae; Indo-Pacific; Mitochondrial RNA; Molecular phylogeny2007
67 Williams, Clayton C.Modeling and experimental investigation of cantilever dynamics in force detected single electron tunnelingThe dynamic response of a voltage biased oscillating cantilever probe is investigated through experimental and theoretical analysis as it approaches a dielectric surface. When the tip reaches the appropriate gap single electron tunneling events are detected between the metallic tip and the surface. ...Oscillating cantilever probe; Electron tunneling2004
68 Poulter, Charles DaleFarnesyl diphosphate synthetase: molecular cloning, sequence, and expression of an essential gene from Saccharomyces cerevisiaeFarnesyl diphosphate (FPP) synthetase is a key enzyme in isoprenoid biosynthesis which supplies C15 precursors for several classes of essential metabolites including sterols, dolichols, and ubiquinones. The structural gene for FPP synthetase was isolated on a 4.5-kilobase EcoRI genomic restriction f...Genetics; Transferases; Dimethylallyltranstransferase/biosynthesis1989-11-15
69 Capecchi, Mario R.Illegitimate cre-dependent chromosome rearrangements in transgenic mouse spermatids.The bacteriophage P1 Cre/loxP system has become a powerful tool for in vivo manipulation of the genomes of transgenic mice. Although in vitro studies have shown that Cre can catalyze recombination between cryptic "pseudo-loxP" sites in mammalian genomes, to date there have been no reports of loxP-si...Chromatin; Female; Mice, Inbred C57BL; Phenotype2000-12-05
70 Olivera, Baldomero M.Poly(ADP-ribosylation) of DNA topoisomerase I: a nuclear response to DNA-strand interruptionsDNA in eukaryotic chromosomes is organized differently from prokaryotic DNA. It seems highly probable that mechanistic adjustments have been made in macromolecular DNA metabolism as a consequence of the chromatin structure of the eukaryotic chromosome (Igo-Kemenes et al. 1982)). This paper deals ...Poly(ADP-ribosylation); Poly(ADP-ribose) synthetase; DNA strand interruption1984
71 Adler, Frederick R.Departure time versus departure rate: how to forage optimally when you are stupidForagers unable to leave a patch at the optimal moment must act as constrained foragers. Extending the results of Houston and McNamara (1985), we compare a blundering forager that leaves patches at a constant rate with an unconstrained optimal forager that leaves patches at the optimal time.Blundering Foragers; Foraging; Marginal Value Theorem1999
72 Beckerle, Mary C.; Clark, Kathleen A.Conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegansWe describe here the molecular and functional characterization of the Caenorhabditis elegans unc-97 gene, whose gene product constitutes a novel component of muscular adherens junctions. UNC-97 and homologues from several other species define the PINCH family, a family of LIM proteins whose modula...LIM domains; Caenorhabditis elegans; UNC-97; Adherens junction; Touch neuron; Muscle development1999
73 Olivera, Baldomero M.Novel Conus peptide ligand for K+ channelsVoltage-gated ion channels determine the membrane excitability of cells. Although many Conus peptides that interact with voltage-gated Na+ and Ca2+ channels have been characterized, relatively few have been identified that interact with K+ channels. We describe a novel Conus peptide that intera...Conus peptides; Conotoxins2003
74 Gondolo, PaoloEffect of dark matter on the first stars: a new phase of stellar evolutionDark matter (DM) in protostellar halos can dramatically alter the current theoretical framework for the formation of the first stars. Heat from supersymmetric DM annihilation can overwhelm any cooling mechanism, consequently impeding the star formation process and possibly leading to a new stellar ...Dark stars2008
75 Mattis, Daniel C.Electron-phonon interaction in two dimensions: the case for strong coupling in high-Tc superconductorsA particular model interaction between electrons and acoustic phonons is found to cause electrons to become weakly "self-trapped" for an arbitrary filling factor in d=2, but not in d=1 nor, for different reasons, in d>3. To the extent that electron kinetic energy is reduced in d=2, the electronic in...Strong coupling1987-09
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