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Creator | Title | Description | Subject | Date |
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Kim, Alexander H. | DPP Signal Regulation Through O-Linked Glycosylation | Dorsal closure in Drosophila is an embryogenic event that involves coordinated cellular shape changes. A series of interconnected signaling cascades are utilized to accomplish this task, one of which is the Decapentaplegic (Dpp) pathway. Dpp is a member of the TFG-β family of secreted cytokines, wh... | | 2017 |
2 |
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Stevenson, Kincade | Synthesis and mechanistic experiments of photoelectrocyclization reactions of pyridine containing BIS-ARYL cyclohexenones | Electrocyclization reactions are commonly found in synthetic chemistry as a means to access cyclic systems and to define stereocenters. Rules for electrocyclization were developed by Woodward and Hoffman, and these rules allow chemists to predict the stereochemical outcome of potential electrocycliz... | | 2021 |
3 |
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Jones, Kathryn K. | Hybrid Enzyme-Bimetallic Nanoparticle System for Tandem Oxidation Catalysis | Metallic nanoparticles are commonly used as catalysts in industrial and academic settings. Recent observations that bimetallic nanoparticles can have enhanced activity over their monometallic counterparts has increased the interest in their synthesis and application to new catalytic systems. Combini... | | 2020 |
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Cowley, Jacob | Optimization of total synthesis of indolizidine alkaloids VIA nickel catalyzed (4 + 2) cyclization utilizing silyl and stannyl alkynes | In order to expand the versatility of the synthetic route to naturally occurring indolizidine alkaloids previously developed in the Louie Group, a path was developed using a bicyclic azetidinone to produce indolizidine alkaloids such as (+)-seco-antofine. However, due to the asymmetric nature of the... | | 2021 |
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Thomas, J Payton | Stability of genetic oscillators with distributed delayed feedback | Genetic oscillators govern periodic phenomena in biology including circadian rhythms and are also the basis of biological clocks used in the design of synthetic genetic circuits. Models of genetic oscillators tend to neglect biological detail, however, because biological systems tend to be too compl... | | 2023 |
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Beseris, Ethan | Biological impact protection in human facial hair | Our study investigated selective mechanisms that influenced the evolution of facial hair in human males (Homo sapiens). Beards are often perceived as an indicator of masculinity and social dominance in men, suggesting that they may play a role in male contest competition. Some authors propose that t... | | 2018 |
7 |
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Ellis, James H. | Refractory status epilepticus and chronic kidney disease in a large pedigree due to a variant in the mitochondrial encoded trna phenylalanine (MT-TF) gene | Mitochondrial disorders present with a wide spectrum of neurological manifestations. Clinical syndromes are described largely by phenotypic indicators. Epilepsy is a common but not universal feature. Myoclonus epilepsy with ragged red fibers (MERRF) is a common clinical syndrome that presents with e... | | 2018 |
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Guernsey, Michael | Mclr is not solely responsible for pigmentation variation among domestic pigeons | Feather pigmentation in the domesticated rock pigeon, Columba livia, is stunningly diverse. Plumage pigmentation in this, and other, columbid (pigeon and dove) species plays an important role in mate choice and thus is a driving factor in the process of sexual selection. To study the genetic basis o... | | 2012 |
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Hayashi, Samantha | The Mechanism of Lysosome Movement During ER Stress | The Endoplasmic Reticulum (ER) is a cellular organelle responsible for the synthesis and folding of secretory proteins. When protein import into the ER exceeds the its protein folding capacity, misfolded proteins accumulate and can potentially become toxic to the cell. This situation, termed ER stre... | | 2019 |
10 |
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Fackler, Anderson N. | Identification of Kin-20 and UNC-119 Knockout suppressors associated with neuronal development and maintenance in C. elegans | Neurons comprise the nervous system-the essential signaling and communication system for nearly all multicellular organisms. To coordinate cells across an entire organism, they must grow to be relatively long. Therefore, neurons extend axons from the cell body. Immature neurons extend growth cones a... | | 2018 |
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Fischer, Paul | High-Performance Computing Performance Metric Analysis | At present, a signi#12;cant amount of ongoing scienti#12;c research relies on computational models. High-performance computing (HPC) resources are often required to obtain results in a reasonable amount of time. However, as physical and practical limitations constrain the performance progression of ... | | 2019 |
12 |
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Skedros, Gregory Athanasios | Structural and material changes in the sheep radius from newborn to adult: Functional adaptation versus developmental constraint | Bones that exhibit marked changes in structural and material characteristics during ontogeny are potentially useful for studying the mechanisms that produce functional adaptations. The diaphyseal region of the sheep radius was examined because it is relatively simply loaded in cranial-caudal bending... | Functional adaptations - Sheep; Developmental constraint - Sheep; Ontogeny | 2015-08 |
13 |
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Auduong, Priscilla | Spinal muscular atrophy modeled in drosophila melanogaster | Spinal Muscular Atrophy (SMA) is the most commonly inherited cause of death in children (Park, Kariya, & Monani, 2010 for review). This disease is characterized by a loss of motor neurons which leads to muscle degeneration, paralysis, and eventual death by respiratory failure (Monani, 2005 for revie... | Spinal muscular atrophy - Research; Drosophila melanogaster - Researcher | 2012-05 |