Honors Theses Open Access
 
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CreatorTitleDescriptionSubjectDate
1 Bischoff, AmandaElucidating the Mechanism and Predicting the Selectivity of the bis(Pyridine) Silver Permanganate OxidatiinThe Movassaghi group has recently reported several total syntheses of epipolythiodiketopiperazine derivatives (ETPs), a class of natural products with potent biological activity. A crucial step in their synthesis oxidizes two to four tertiary C-H bonds to form tertiary alcohols using (bis)pyridine s...2016
2 Astin, Holly M.Modulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in Zebrafish2016
3 Russell, NicoleThe Role of Introns Within Alpha Conotoxin Genes in Cone SnailsCone snails, of which there are more than 600 species, have attracted a lot of attention. Cone snails, found in warm tropical waters across the world, are predators and produce venoms comprising diverse toxins. These toxins, termed conotoxins, have been the subject of a great amount of research. Whi...2016
4 Hanes, Josh T.A comparison of nuclear thermal rockets with traditional chemical rockets for space transportThe Solar System has multiple destinations that private and governmental space agencies are planning to explore. Missions within the Solar System are both exorbitantly expensive and time intensive projects that involve high risks for the organizations involved. A mission that is currently being...Nuclear rockets - research; space vehicles - design - research; nuclear thermal rockets; chemical rockets; space transport2016-04
5 Simon, Philip C.A study of the optimized load of a traveling wave thermoacoustic heat engineThermal interaction between differentially heated solid material and ambient gas in a resonator can lead to self-sustained oscillations or the transportation of heat in accordance with the thermoacoustic effect, first explained by Lord Rayleigh. In this research the phenomenon is employed in a lo...Thermoacoustic engine - Research; Energy conservation2016-03
6 Renz, AndyAssessment of exercise-stimulated tissue oxygenation in calf muscle with functional MRIPeripheral artery disease (PAD) affects millions of patients in the USA, and effective diagnosis and management of PAD is a major clinical goal. One promising avenue of research towards the goal is through functional MRI, which provides non-invasive measurement of tissue oxygenation. For a group of ...Arteries - Diseases - Diagnosis; Magnetic resonance imaging - Research; Calf muscle; Peripheral arterial disease; MATLAB2016-04
7 Barbeau, WilliamCharacterization of a New Ribosome Associated Quality Control PathwayProteins are life's double edged sword. Proteins are essential macromolecules of life, and the tasks that some proteins accomplish are quite marvelous. At the same time, if proteins misfold they have the potential to kill the cell that harbors them. It is becoming increasingly clear that proteins ha...Ribosomes - Research2016-12
8 Visser, JoshuaCharacterization of G-quadruplexes in DNA repair protein gene sequences and the effects of oxidized guanine lesions on DNA base insertion and elongationGuanine (G) is one of the four nucleo bases that make up the complex macromolecule deoxyribonucleic acid (DNA). In addition to its ability to Watson-Crick base pair with cytidine (C), guanine can base pair with itself vianon-canonical, Hoogsteen base pairing and form a secondary structure of DNA ca...DNA repair - Research; G proteins - Pathophysiology - Research; Oxidation, Physiological - Research; Membrane homogenization; Synthetic blood; Artificial oxygen carriers2016-05
9 Odendahl, NathanComparison of popular force fields for molecular modeling of proteins applied to ice binding of the tenebrio molitor antifreeze proteinIce Binding Proteins (IBPs) are a class of proteins that affect the melting and freezing temperatures of ice. While substantial research has been conducted to understand the properties of IBPs, experimental and molecular dynamics simulations have not satisfactorily explained the mechanism of the i...Antifreeze proteins - Research; Ice binding proteins; Tenebrio molitor; Antifreeze protein; Force fields2016-04
10 Christensen, MasenCooperative primers: Intersecting spherical model for optimization of linker and gap lengthsDetection of specific sequences of DNA is invaluable for diagnosing the presence of a pathogen, as well as other areas of genetic analysis. A common way of detecting DNA is replicating it millions of times through Polymerase Chain Reaction (PCR) and using fluorescent molecules to detect those copies...Pathogenic microorganisms - Detection; DNA - Research; Polymerase chain reaction - Research; Cooperative primers; Aluminum foam materials; Load frame2016-05
11 Lim, Koun (Kasha)Deglycoyslation of glucose oxidase and its application within high power enzymatic fuel cellsTo compensate for the increase of carbon dioxide level and the energy exhaust, an enzymatic fuel cell (EFC) has been investigated by researchers. In the paper, a chemical oxidative deglycosylation of an enzyme was investigated to furture improve EFCs. By deglycosylating an enzyme, the distance betwe...Fuel cells - Research; Electric power - Research; Deglycosylation; Enzymatic fuel cell; Glucose oxidase2016-04
12 Dart, EmilyDiversity and metabolic potential of microbial communities in a site of continental serpentinizationThe geochemical process of serpentinization releases energy and organic carbon: two of the basic requirements need ed to support life. Sites of active serpentinization in the deep subsurface provide the intriguing possibility of a non-photosynthetically -supported biosphere. However, serpentinizatio...Microbial ecology - Research; Serpentine - Environmental aspects; Gros Morne National Park (N.L.); Syntrophomonadaceae; Serpentinizaiton; Tabeland Ophiolite2016-05
13 Lebrecht, MarandaEffects of ventilatory regimens on the prevalence of a common gastrointestinal disease in neonatesNecrotizing Enterocolitis, or NEC, is a common intestinal disease of preterm neonates. It is believed that bacterial colonization increases the risk of NEC. This study examines whether the type of ventilation of the neonate, either mechanical ventilation (MV) or non-invasive support (NIS), and the ...Enterocolitis, Neonatal necrotizing - Research; Newborn infants - Diseases; Sheep as laboratory animals - Research; Necrotizing enterocolitis; Lymphocytes2016-05
14 Bowen, BradyFractal geometry of melt ponds: Modeling the fractal geometry of arctic melt ponds using the level sets of random surfacesDuring the late spring, most of the Arctic Ocean is covered by sea ice with a layer of snow on top. As the snow and sea ice begin to melt, water collects on the surface to form melt ponds. As melting progresses, sparse, disconnected ponds coalesce to form complex, self-similar structures which are c...Melt pond geometry2016-04
15 Acosta, LehiGenotype-dependent susceptibility to influenza and titer-virulence discordanceThe influenza a virus (IAV) is a major source of human mortality and both recent and anticipated pandemics make understanding this major human pathogen of paramount importance1,2. The use of mouse models allows us to experimentally manipulate critical variables to more fully understand the dynamics ...Influenza A virus - Research; Mice as laboratory animals - Research; Transmissibility; Virulence; Viral titers; Erythropoeintin2016-05
16 Zurbuchen, RudiMacrocyclization of glucagon-like peptide (GLP-1) by thiol-ene reactionMacrocyclization of peptides helps maintain a stable alpha helical structure using a conformational constraining staple. One such peptide, glucagon-like peptide-1 (GLP-1), is a 37 amino acid peptide agonist for the GLP-1 receptor and has the ability to lower blood glucose levels and is responsible ...Peptide hormones - Receptors - Research; Ring formation (Chemistry) - Research; Macrocyndization; GLP-1; Swim kinematics; Pre-pulse inhibition2016-05
17 Astin, M. HollyModulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in ZebrafishThe liver X receptors (LXRs) are important regulators of lipid and cholesterol metabolism and control diverse pathways in development, reproduction, metabolism, immunity and inflammation. Thus, LXRs have potential as therapeutic targets for diseases as diverse as lipid disorders, atherosclerosis...Liver X receptors - Research; Zebrafish - genetics2016-08
18 Nau, AdamThe role of heparan sulfate in maintaining stereotyped birdsongSong learning in Zebra Finches (Taeniopygia guttata) occurs during a critical period between 30-90 post hatch days, and involves acquisition of an acoustic model and a sensorimotor period of increasingly improving imitation of this model. Young birds sing highly variable songs early during this pe...Birdsongs - Research; Zebra finch - Research; Songbirds - Behavior; Heparan sulfate; Taeniopygia guttata; Neural circuitry2016-04
19 Du, WantongThe role of mRNA decay in a genetic switchGenes can be switched on or off by regulatory proteins. For example, two genes may each synthesize a protein that downregulates the other gene, creating a repressor- repressor switch that has two stable steady states: one being when the first gene is "on" and the second gene is repressed, and the ot...Messenger RNA - Research; Genetic regulation - Research; Genetic switch; Gene repression; Neural circuitry2016-04
20 Hunter, SamuelSignaling Role of the Hamp Domain in the Escherichia Coli Serine ChemoreceptorThe chemoreceptor Tsr enables Escherichia coli to track serine gradients in its environment. Binding of serine to the periplasmic domain propagates a signaling conformational change through other domains of the chemoreceptor molecule to modulate the activity of CheA, a kinase associated with t...Chemoreceptors - Research2016-07
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