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Creator | Title | Description | Subject | Date |
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Loret, Amy | Genetic Modifiers of Severity in Collagen VI-Related Muscular Dystrophy | Collagen VI-related muscular dystrophies (COL6-RD) display phenotypic heterogeneity that includes mild Bethlem myopathy (BM), intermediate (INT), and severe Ullrich congenital muscular dystrophy (UCMD) phenotypes. COL6-RD are characterized by mutations within the collagen VI genes (COL6A1, COL6A2, a... | | 2019 |
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Wheeler, Maya | Role of WNT-Dependent Neurogenesis in Functional Recovery Following Spinal Cord Injury | In humans and other adult mammals, spinal cord injury leads to a permanent loss of motor and sensory function. The biggest obstacle to recovery is the inability of severed axons and neurons to regenerate. During embryogenesis, all vertebrates have a population of neural stem cells called radial glia... | | 2019 |
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Skedros, Gregory Athanasios | Structural and material changes in the sheep radius from newborn to adult: Functional adaptation versus developmental constraint | Bones that exhibit marked changes in structural and material characteristics during ontogeny are potentially useful for studying the mechanisms that produce functional adaptations. The diaphyseal region of the sheep radius was examined because it is relatively simply loaded in cranial-caudal bending... | Functional adaptations - Sheep; Developmental constraint - Sheep; Ontogeny | 2015-08 |
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Sperber, Alexander M. | A novel approach to differentiating cardiac fibroblasts from induced pluripotent stem cells | Heart disease remains the leading cause of death in the United States, and such disease is caused by electrical, chemical, or biomechanical imbalances in the heart. The two most abundant cells comprising the heart that are responsible for these functions are cardiomyocytes and cardiac fibroblasts. I... | | 2022 |
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Walker, Kortnie | Understanding and treating diabetic retinopathy | Diabetic retinopathy is a neurovascular disease of the retina and is the leading cause of blindness in the working-age population in the United States. Complications as a result of hyperglycemia and diabetes mellitus (DM) break down the blood-retina barrier (BRB) and retinal vasculature. Current tre... | Diabetic retinopathy | 2015-05 |
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Tang, Anna | Mathematical model of drug resistance in ER+ breast Cancer: the role of the microenvironment | One of the main obstacles to treating cancer is its ability to evolve and resist treatment. In this project, we are primarily interested mathematically modeling how the cancer microenvironment interacts with cancer cells and affects cancer's response to therapy. We aim to develop the mathematical mo... | | 2023 |
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Au, Alexander | Impact of population density of left atrial remodeling in patients with atrial fibrillation | Atrial fibrillation (AF), the most common cardiac arrhythmia and a leading cause of stroke, is characterized by structural changes, or remodeling, in tissues of the left atrium (LA). Late Gadolinium-Enhancement Magnetic Resonance Imaging (LGE-MRI) can noninvasively detect remodeling in the LA, allow... | Atrial fibrillation Treatment | 2012-05 |
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Nguyen, Nam | Roles of Transient Receptor Potenitial Ankyrin-1 and Vanilloid-3 in Endoplasmic Reticulum stress and Cytotoxicity in Lung Epithelial Cells | Air pollution is a growing global health issue with considerable local relevance. In particular, exposure to wood smoke particulate matter (WSPM) is associated with the development and exacerbation of chronic inflammatory conditions and irreversible damage of the airways and alveoli. However, exact ... | | 2020 |