Honors Theses Open Access
 
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1 Ellingson, DrewBitangent lines to planar quartic curves in algebraic and tropical geometryBitangents are lines which are tangent to a curve at two points. The bitangents of a classical quartic are well understood, and a result originally due to Cayley tells us that there are always precisely 28 bitangents to a generic quartic plane curve. When looking at Tropical Geometry, the situation ...Tropical geometry; Curves, Quartic; Curves, Algebraic; Bitangents2015-04
2 Wheeler, MayaRole of WNT-Dependent Neurogenesis in Functional Recovery Following Spinal Cord InjuryIn humans and other adult mammals, spinal cord injury leads to a permanent loss of motor and sensory function. The biggest obstacle to recovery is the inability of severed axons and neurons to regenerate. During embryogenesis, all vertebrates have a population of neural stem cells called radial glia...2019
3 Besic, ArnelCreation and characterization of organic mixed conductorsOrganic mixed ionic electronic conductors (OMIECs) are conjugated polymers that conduct both ions and electrons. These materials are promising for applications in healthcare and energy technologies, including biosensors and batteries. An obstacle for using these materials in next-generation technolo...2024
4 Cantrell, Rachel Lou-La VonneSynthesis of Antibiotic Scaffolds Inspired by the Tan 1057-D Biologically Active Natural Product Through the Utilization of Ullmann Copper(I) and Gold Cyclization ChemistryAs bacterial resistance to drugs continues to rise, the search for new antibiotics is of paramount importance. One key element to finding successful antibiotics is to uncover small molecules that act through novel mechanisms of action in order to decrease the risk of cross-resistance and provide ant...2020
5 Zurbuchen, RudiMacrocyclization of glucagon-like peptide (GLP-1) by thiol-ene reactionMacrocyclization of peptides helps maintain a stable alpha helical structure using a conformational constraining staple. One such peptide, glucagon-like peptide-1 (GLP-1), is a 37 amino acid peptide agonist for the GLP-1 receptor and has the ability to lower blood glucose levels and is responsible ...Peptide hormones - Receptors - Research; Ring formation (Chemistry) - Research; Macrocyndization; GLP-1; Swim kinematics; Pre-pulse inhibition2016-05
6 Evans, Kathryn S.Defining the interaction between ETV4 and mediator subunit MED25Chromosomal rearrangements resulting in an overexpression of a subset of ETS transcription factors (ETV1, ETV4, ETV5, and ERG) are found in over 50% of prostate cancers (Tomlins et al., 2005). ERG and ETV1 have both shared and distinct gene targets, yet overexpression of ETV1 is often found to be as...Transcription factors; Prostate -- Cancer -- Genetic aspects; ETV42015-05
7 Wang, WenyiImaging in a homogeneous aluminum plate by using ultrasonic wavesThis project is about detecting and imaging damage (such as cracks) in a plate by using ultrasonic waves. The waves are generated by a source (an ultrasonic transducer) that is part of a robot that can move on the plate. The waves traveling in the plate are recorded at a receiver (another ultrasonic...Ultrasonic transducer - Mathematics; Kirchoff migration - Research2014-12
8 Checketts, CynthiaWhy white mice? improving biological literacy through animal historyThroughout the undergraduate experience, biology students are introduced to hundreds of experiments, theories, and principles, many of which are rooted in animal experimentation. However, in required and information-heavy biology courses, the erasure of animals from the scientific story-which repres...2021
9 Lebrecht, MarandaEffects of ventilatory regimens on the prevalence of a common gastrointestinal disease in neonatesNecrotizing Enterocolitis, or NEC, is a common intestinal disease of preterm neonates. It is believed that bacterial colonization increases the risk of NEC. This study examines whether the type of ventilation of the neonate, either mechanical ventilation (MV) or non-invasive support (NIS), and the ...Enterocolitis, Neonatal necrotizing - Research; Newborn infants - Diseases; Sheep as laboratory animals - Research; Necrotizing enterocolitis; Lymphocytes2016-05
10 Estrada, JohannaBCR-ABL1 compound mutations combining key kinase domain positions confer clinical resistance to ponatinib in Philadelphia cromosome-positive leukemiaCML 1s caused by a random reciprocal translocation that joins the ABL1 gene on chromosome 9, with the BCR gene on chromosome 22. The result is the formation of the oncogenic BCR-ABL1 gene. This derivative chromosome is widely known as the Philadelphia Chromosome (Ph+), and it encodes a deregulated, ...Leukemia -- Genetic aspects -- Research Leukemia -- Treatment -- Research2014-04
11 Mercer, MarianneEstablishing a System for Structure-Function analysis of the Novel Role that NUP153 Plays in Nuclear AssemblyIn mitosis, equal partitioning of DNA between daughter cells requires an integrated series of events. At the start of anaphase the chromatin separates and forms two chromatin discs. This chromatin is then targeted by nuclear membrane proteins and membrane to form the nuclear envelope. These membrane...2018
12 Guernsey, MichaelMclr is not solely responsible for pigmentation variation among domestic pigeonsFeather pigmentation in the domesticated rock pigeon, Columba livia, is stunningly diverse. Plumage pigmentation in this, and other, columbid (pigeon and dove) species plays an important role in mate choice and thus is a driving factor in the process of sexual selection. To study the genetic basis o...2012
13 Owen, Cameron J.Infrared Multiple Photon Dissociation Spectroscopy and Guided Ion Beam Tandem Mass Spectrometry: Experimental and Theoretical investigations of Transition Metal and Lanthandie CationsEmployment of Free Electron Lasers (FELs) and a Guided Ion Beam Tandem Mass Spectrometer (GIBMS) has allowed for the spectroscopic and spectrometric investigations of a variety of ionic complexes, respectively. The data presented in Chapters 2 and 3 of this thesis were obtained using two FELs locate...2019
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