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Creator | Title | Description | Subject | Date |
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Sullivan, Steven M. | A trace formula for G2 | An n-dimensional matrix representation of a group G on a vector space V is a homomorphism from G to GL(V). For our purposes, we consider an irreducible representation to be a representation which cannot be decomposed into the direct sum of smaller-dimensional representations. Let H be a subgroup of ... | Trace formulas | 2013-05 |
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Kent, Alexandra | DNA split aptamers as a biosensing platform for the detection of small drug molecules | Prescription drug overdose and abuse is a leading cause of death in the United States. It is a serious issue and has become increasingly problematic as opioids are being prescribed with a higher frequency. For this reason, fast, accurate detection of small drug molecules is crucial. The current stan... | Drug testing; Biosensors; DNA split aptamers | |
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Pecchia-Bekkum, Annika | Applications of controlled DNA assembly and disassembly in biosensing and responsive drug delivery | Deoxyribonucleic acid (DNA) provides many exciting functions outside of simply encoding genetic information. Herein, we report two techniques to control the assembly and disassembly of nucleic acids. Within these techniques, DNA is used as a programmable material for biosensing and drug delivery. In... | Nucleic acids - Biotechnology | 2013-08 |
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Lee, Charles Chang Suk | A demonstration apparatus for optical pumping of rubidium | Optical pumping refers to the use of light in order to elevate ("pump") the spin (intrinsic angular momentum) of an atom or molecule. This process is of interest from a pedagogical and experimental perspective because it encapsulates fundamental properties of atomic physics and quantum mechanics. Fu... | Optical pumping -- Research Spin exchange -- Research Rubidium isotopes -- Research | 2015-05 |
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Arave, Rowan A. | AKT1 activation promotes the development of melanoma metastasis | Metastases are the major cause of melanoma-related mortality. Previous studies implicating aberrant AKT (or protein kinase B) signaling in human melanoma metastases led to the evaluation of the effect of activated AKT1 expression in non-metastatic BRAFV600E/cyclin dependent kinase inhibitor 2a nu... | Melanoma - Genetics - Research; Metastasis - Genetics - Research; Biochemistry; Genetics | 2015-12 |
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Gardner, Jenna | The Disparity Between Student Science Writing and Professional Sciencetific Writing | There exists a disparity between student scientific writing and professional scientific writing. The audience, format, and intention of student papers as presented in the science classroom is different from those in the scientific field where the goal is to fully convince an unfamiliar audience and ... | | 2017 |
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Bowen, Brady | Fractal geometry of melt ponds: Modeling the fractal geometry of arctic melt ponds using the level sets of random surfaces | During the late spring, most of the Arctic Ocean is covered by sea ice with a layer of snow on top. As the snow and sea ice begin to melt, water collects on the surface to form melt ponds. As melting progresses, sparse, disconnected ponds coalesce to form complex, self-similar structures which are c... | Melt pond geometry | 2016-04 |
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Visser, Joshua | Characterization of G-quadruplexes in DNA repair protein gene sequences and the effects of oxidized guanine lesions on DNA base insertion and elongation | Guanine (G) is one of the four nucleo bases that make up the complex macromolecule deoxyribonucleic acid (DNA). In addition to its ability to Watson-Crick base pair with cytidine (C), guanine can base pair with itself vianon-canonical, Hoogsteen base pairing and form a secondary structure of DNA ca... | DNA repair - Research; G proteins - Pathophysiology - Research; Oxidation, Physiological - Research; Membrane homogenization; Synthetic blood; Artificial oxygen carriers | 2016-05 |
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Kim, Bum Jun | Does ceramide contribute to vascular dysfunction in mice with type 1 diabetes? | Approximately 2 million individuals have type 1 diabetes (T1D) in the United States. Cardiovascular disease is 2-4-fold more prevalent in these patients but the mechanism(s) is unclear. Recently, we showed that the sphingolipid ceramide contributes to arterial dysfunction and hypertension in mice wi... | Ceramide - Research; Type 1 Diabetes; Mice as laboratory animals | 2012-05 |
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Thompson, Lauren | SptlC2 Deletion in Endothelial Cells: Implications for Arterial Function | Using pharmacological and genetic approaches to inhibit whole-body ceramide biosynthesis, our laboratory showed that this sphingolipid contributes importantly to hypertension and vascular dysfunction associated with diet-induced obesity in mice. Here we tested the hypothesis that inducible, endothel... | | 2020 |
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Nguyen, Nam | Roles of Transient Receptor Potenitial Ankyrin-1 and Vanilloid-3 in Endoplasmic Reticulum stress and Cytotoxicity in Lung Epithelial Cells | Air pollution is a growing global health issue with considerable local relevance. In particular, exposure to wood smoke particulate matter (WSPM) is associated with the development and exacerbation of chronic inflammatory conditions and irreversible damage of the airways and alveoli. However, exact ... | | 2020 |
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Fan, Huijun | Examination of Y-Deterium isotope effects for the solvolysis of model isoprenoid compounds | Model isoprenoid compounds can undergo two distinct pathways, dissociative or associative nucleophilic substitution depending on the conditions used. The dissociative pathway consists of two steps, involving a carbocation intermediate where the formation of that carbocation is rate determining. The ... | Isopentenoids; Solvolysis; Deuterium - Isotopes | 2012-05 |
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Watson, Andre | Patterns of parasitism in a common Utah Rodent | Male-biased parasitism, where males are more commonly infected with and have higher parasite loads, is common across vertebrate taxa. Several factors could be driving this pattern. The immunocompetence handicap hypothesis suggests that higher testosterone levels in males suppress immune function whi... | | 2022 |
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Jensen, Madeline | Changes in microbial diversity in storm-water green infrastructure | Increased urbanization has led to excess nutrients in urban ecosystems. Stormwater Green Infrastructure (SGI) is a method to capture these nutrients and prevent runoff. However, an increased understanding of ecosystem processes is needed to create more efficient SGIs. Past studies have shown that pl... | | 2022 |
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| Effects of Acute Hypoxia and High pCO2 on Total Protein Content and Metabolic Enzyme Activity in Rockfishes (Sebastes SPP.) | Climate change is altering ocean chemistry and wind-driven upwelling regimes. In the California Current System (CCS), these changes are exposing nearshore fishes to increasing levels of high pCO2 and hypoxia. These stressors co-occur during upwelling events, lasting hours to days, and both have the ... | | 2019 |
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Wang, Wenyi | Imaging in a homogeneous aluminum plate by using ultrasonic waves | This project is about detecting and imaging damage (such as cracks) in a plate by using ultrasonic waves. The waves are generated by a source (an ultrasonic transducer) that is part of a robot that can move on the plate. The waves traveling in the plate are recorded at a receiver (another ultrasonic... | Ultrasonic transducer - Mathematics; Kirchoff migration - Research | 2014-12 |
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Roestenburg, Jessica | Testing the Perceptual Salience of Spectral Content in Zebra Finch Song | Birds actively adjust the resonance properties of the upper vocal tract during singing, which results in specific harmonic structures of song elements. To what degree upper vocal tract filtering is relevant for the perceptual salience of song is poorly understood. This research utilizes (1) a biolog... | | 2018 |
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Owen, Cameron J. | Infrared Multiple Photon Dissociation Spectroscopy and Guided Ion Beam Tandem Mass Spectrometry: Experimental and Theoretical investigations of Transition Metal and Lanthandie Cations | Employment of Free Electron Lasers (FELs) and a Guided Ion Beam Tandem Mass Spectrometer (GIBMS) has allowed for the spectroscopic and spectrometric investigations of a variety of ionic complexes, respectively. The data presented in Chapters 2 and 3 of this thesis were obtained using two FELs locate... | Netherlands; thermochemical; Natural | 2019 |
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Wheeler, Maya | Role of WNT-Dependent Neurogenesis in Functional Recovery Following Spinal Cord Injury | In humans and other adult mammals, spinal cord injury leads to a permanent loss of motor and sensory function. The biggest obstacle to recovery is the inability of severed axons and neurons to regenerate. During embryogenesis, all vertebrates have a population of neural stem cells called radial glia... | | 2019 |
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Cantrell, Rachel Lou-La Vonne | Synthesis of Antibiotic Scaffolds Inspired by the Tan 1057-D Biologically Active Natural Product Through the Utilization of Ullmann Copper(I) and Gold Cyclization Chemistry | As bacterial resistance to drugs continues to rise, the search for new antibiotics is of paramount importance. One key element to finding successful antibiotics is to uncover small molecules that act through novel mechanisms of action in order to decrease the risk of cross-resistance and provide ant... | | 2020 |
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Kannan, Sarmishta Diraviam | The Role that Lysosomes and Autophagy play in Alveolar soft parts Sarcoma, clear cell Sarcoma and Synovial Sarcoma | Sarcomas are cancer of the connective tissue and are very deadly group of cancers. Two of the sarcoma types, alveolar soft parts sarcoma (ASPS) and clear cell sarcoma (CCS) have a unique vacuolar morphology. This unique morphology is absent in synovial sarcoma (SS). We believe that the unusual morph... | | 2017 |
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Sperber, Alexander M. | A novel approach to differentiating cardiac fibroblasts from induced pluripotent stem cells | Heart disease remains the leading cause of death in the United States, and such disease is caused by electrical, chemical, or biomechanical imbalances in the heart. The two most abundant cells comprising the heart that are responsible for these functions are cardiomyocytes and cardiac fibroblasts. I... | | 2022 |
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Zhu, Judy | Analysis of the pH-dependent equilibrium relationship between the guanine oxidation products 5-guanidinohydantoin and iminoallantoin | Oxidation of 2'-deoxyguanosine (dG) results in the major two-electron product 8-oxo-7,8-dihydro-2'-deoxyguanosine (dOG) that can undergo further oxidation to other products. One such product is 5-guanidinohydantoin (dGh) that is highly mutagenic and has been found in vivo. The ring architecture of d... | Oxidation; guanine oxidation products; 5-guanidinohydantoin; Iminoallantoin; Equilibrium relationship | 2015-05 |
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Woodruff, Derek | Uncovering Synaptic Defects resulting from loss of the intellectual disability and autism-associated gene Kirrel3 | Neurodevelopmental disorders severely impact an individual's life. Surprisingly, the genetic and cellular cause of over half of intellectual disability cases and more than 80% of autism spectrum disorders remain undiscovered1,2. It is likely that mutations in molecules regulating synapse development... | | 2017 |
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Lan, Yung-Chi | HYPO-osmolarity and glucose starvation localizes slm1 to mitochondria- A novel stress response pathway | Synthetic Lethal with Mss4 1 (Slm1) is a key protein found in the crossroad of the Membrane Compartment of Can1 (MCC) and the Membrane Compartment of TORC2 (MCT). The two compartments on the plasma membrane of budding yeast (Saccharomyces cerevisiae) are responsible for APC transporter regulation an... | | 2022 |