TO
| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
 |
Wang, Alison | Mechanistic studies of the electroanalytic reduction of CO2 TO CO: A BPY-MN(CO)3Coome model | Transition-metal electrocatalysts have previously been shown to convert carbon dioxide to carbon monoxide, which is promising for future energy schemes. Recent efforts have focused on (N^N)Mn(CO)3X complexes due to their performance and exclusion of expensive metals (X = anionic ligand, N^N = bident... | 2023 | |
| 2 |
 |
Sageser, Emily | Understanding the radial distribution of dwarf satellite galaxies beyond the virial radii | Dark matter has been theorized to exist for over 80 years based on astronomical observations but has yet to be found in terrestrial experiments. Named for its lack of interaction with the electromagnetic field, dark matter does not absorb, reflect, or emit electromagnetic radiation making it undetec... | 2023 | |
| 3 |
 |
Cowley, Jacob | Optimization of total synthesis of indolizidine alkaloids VIA nickel catalyzed (4 + 2) cyclization utilizing silyl and stannyl alkynes | In order to expand the versatility of the synthetic route to naturally occurring indolizidine alkaloids previously developed in the Louie Group, a path was developed using a bicyclic azetidinone to produce indolizidine alkaloids such as (+)-seco-antofine. However, due to the asymmetric nature of the... | 2021 | |
| 4 |
 |
Tang, Anna | Mathematical model of drug resistance in ER+ breast Cancer: the role of the microenvironment | One of the main obstacles to treating cancer is its ability to evolve and resist treatment. In this project, we are primarily interested mathematically modeling how the cancer microenvironment interacts with cancer cells and affects cancer's response to therapy. We aim to develop the mathematical mo... | 2023 | |
| 5 |
 |
Identification of potential causes for increased central line associated bloostream infection rates in the University of Utah NICU | The University of Utah Newborn Intensive Care Unit (UUNICU) has seen a recent increase in rate of Central Line Associated Bloodstream Infection (CLABSI) after an extended period of 965 days with no CLABSI's. Unfortunately, in the last three years, infection rate has been on average 2.6 CLABSI per ye... | 2023 | ||
| 6 |
 |
Halberg, Charles | On causality in machine learning | Although the studies of causal inference and machine learning arose independently, there are emerging intersections which are proving fruitful for both fields. One of the major modern challenges in AI is to develop robust, generalizable models which can perform across a number of different tasks wit... | 2022 | |
| 7 |
 |
Munn, Jackson | Determining microbial community composition and methane flux or red butte canyon sediment over time | Methane is a potent greenhouse gas that is released from the soil into the atmosphere, which contributes heavily to global warming. One potential way of reducing the amount of methane in the air is through studying methane consuming bacteria (methanotrophs) and how they interact with other microbes ... | 2022 | |
| 8 |
 |
Tazehabadi, Tara | Bioinformatics to detect functional interactions important for the DNA repair enzyme mutyh | DNA is the blueprint of all biological life as it provides the means necessary for sharing of genetic information. DNA is formed and stabilized by interactions between four unique bases, Adenine (A), Cytosine (C), Guanine (G), and Thymine (T) which come together in predetermined patterns to create a... | 2022 | |
| 9 |
 |
Thomas, Nathaniel | The HIV-protective bystander effect in macrophages is viral glycoprotein dependent and likely conferred via upregulation of ISG IFITM3 | During an immune response against a specific antigen, often during viral infections, T cells not specific to the antigen can be activated, a phenomenon known as bystander response. The "bystander response" has been studied extensively in T cells, but when examined for macrophages through the lens of... | 2022 | |
| 10 |
 |
Watson, Andre | Patterns of parasitism in a common Utah Rodent | Male-biased parasitism, where males are more commonly infected with and have higher parasite loads, is common across vertebrate taxa. Several factors could be driving this pattern. The immunocompetence handicap hypothesis suggests that higher testosterone levels in males suppress immune function whi... | 2022 | |
| 11 |
 |
Steiner, William | Regulation of protein complexes during hedgehog signal transduction | The Hedgehog (Hh) pathway is an evolutionarily conserved signaling pathway essential in embryonic development and tissue homeostasis. Several cancers can form as a result of Hh pathway dysfunction. The G protein-coupled receptor (GPCR) Smoothened (SMO) is activated upon binding of the secreted Hh pr... | 2021 | |
| 12 |
 |
Rohaj, Aarushi | Apoptosis efficiency of the transfected elephant and human P35 vectors in P53 varying leiomyosarcoma cells | Comparative Oncology is an approach that integrates and connects commonly occurring cancers seen in animals, into studies focused on cancer biology, prevention, and treatment in humans. Studies show that natural mechanisms can suppress cancer 1,000 times more adequately in certain animals than in hu... | 2021 | |
| 13 |
 |
Randolph, Charlotte | Synthesis of VLC-Pufas relating to macular degenerative diseases | Very Long Chain Polyunsaturated Fatty Acids (VLC-PUFAs) are non-dietary fatty acids that are more than 24 carbons long and include more than one double bond. The specific compound we have focused on is 32:6 n-3: a 32-carbon molecule having 6 cis alkenes with the alkenes beginning at the omega 3 carb... | 2022 | |
| 14 |
 |
Narasipura, Eshan Amruth | Full synthesis of enzymatically cleavable linker between 929-designed ankyrin repeat protein and 17-dimethlyamino geldanamycin | Targeted cancer therapeutics are an important and promising field of cancer research due to their ability to reduce the off target effects produced in other therapies such as chemotherapy. Antibody Drug Conjugates (ADC) are one such therapeutic that specifically target cancer cells through antibody-... | 2021 | |
| 15 |
 |
Lee, Hani | Post-traumatic headache: an opportunity to develop new preclinical models for better understanding of pathology and treatment | Post-traumatic headache (PTH) is identified as one of the most frequent symptoms following traumatic brain injury (TBI) (Faux & Sheedy, 2008). Despite the high prevalence, there are currently no treatments which specifically target PTH. Instead of etiology-specific treatments, individuals suffering ... | 2022 | |
| 16 |
 |
Lan, Yung-Chi | HYPO-osmolarity and glucose starvation localizes slm1 to mitochondria- A novel stress response pathway | Synthetic Lethal with Mss4 1 (Slm1) is a key protein found in the crossroad of the Membrane Compartment of Can1 (MCC) and the Membrane Compartment of TORC2 (MCT). The two compartments on the plasma membrane of budding yeast (Saccharomyces cerevisiae) are responsible for APC transporter regulation an... | 2022 | |
| 17 |
 |
Kasera, Shalini | Effect of IUGR and supplemental DHA on molecular mediators of hepatic lipid accumulation in the rat | Intrauterine growth restriction (IUGR) refers to failure of the fetus to achieve its genetic growth potential in utero and is commonly caused by uteroplacental insufficiency secondary to maternal hypertensive disorders. A hallmark of IUGR is a decrease in circulating docosahexaenoic acid (DHA), an �... | 2022 | |
| 18 |
 |
Hahm, Suhyun | Stressors of varying properties induce differences in the modulation of behavior and biology | Stress induces enduring behavioral and biological consequences. Despite its pervasiveness, the biological and neural processes underlying its effects remain largely unknown. The existing literature generally examines the repercussions of stress from the aspect of a single stressor; however, stressor... | 2022 | |
| 19 |
 |
Jensen, Madeline | Changes in microbial diversity in storm-water green infrastructure | Increased urbanization has led to excess nutrients in urban ecosystems. Stormwater Green Infrastructure (SGI) is a method to capture these nutrients and prevent runoff. However, an increased understanding of ecosystem processes is needed to create more efficient SGIs. Past studies have shown that pl... | 2022 | |
| 20 |
 |
Hinchman, Colin | 4D flow characteristics of left atrial blood flow after atrial fibrillation | Atrial fibrillation is the most prevalent cardiac arrhythmia and causes increased risk for stroke, yet accurate pathophysiological diagnosis remains a challenge. This study aimed to further investigate the physiologic biomarkers in the left atrium (LA) related to atrial fibrillation (AF) using 4D fl... | 2019 | |
| 21 |
 |
Godfrey, Rose | A porcine model for the development and testing of preoperative skin preparations | Clinical preoperative skin preparations (PSPs) do not eradicate skin flora dwelling in the deepest dermal regions. Survivors constitute a persistent infection risk. In search of solutions, we created a porcine model intended for PSP developmental testing. This model employed microbiological techniqu... | 2022 | |
| 22 |
 |
Galinat, Shelby | Bipyrimidine solubility modeling for applications in NON-Aqueous redox flow batteries | Energy storage research has undergone transformative changes in the past 50 years. The increasingly concerning threat of climate change has emphasized the need for energy storage technology to facilitate renewable energy incorporation into the grid. Without energy storage, the fluctuations of wind a... | 2022 | |
| 23 |
 |
Furrer, Summer | Cellular and subcellular localization patterns of hepatitis delta virus in sjogren's syndrome salivary gland tissue | Primary Sjogren's syndrome (pSS) is an autoimmune disorder, predominantly affecting women, that causes dry eyes, dry mouth, fatigue, and other extraglandular manifestations (Le Goff et al., 2017). It has been shown that chronic pathogen exposure can lead to development of autoimmune diseases such as... | 2022 | |
| 24 |
 |
Copinga, Aidan | Optimal transport and applications in partial differential equations | In the 18th century, Gaspard Monge created a mathematical framework to find the best way to describe the optimal way to rearrange the dirt dug out from the land into castle walls or other desired shapes. More recently, in the 20th century, Leonid Kantorovich explored infinite dimensional optimizatio... | 2022 | |
| 25 |
 |
Franchina, Jordan Avery | Measurement of bond dissociation energies of transition metal molecules | Measuring thermochemical and kinetic properties of chemical systems has always; been a central theme of chemistry. Knowing these properties assists us in assessing; whether or not a chemical reaction is energetically feasible, efficient, and worthwhile.; Theoretical chemistry has now developed suffi... | Chemical systems; thermochemical; kinetic; modeling | 2018-04 |