Honors Theses Open Access
 
Filters: School Or College: "College of Engineering" Collection: "ir_htoa"
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CreatorTitleDescriptionSubjectDate
1 Gilbert, JohnA novel tool to capture neural activity across an entire brain using C-FOS as an indicatorImmunohistochemical staining for the expression of the immediate early gene c-Fos is a powerful tool to measure neuronal activation of neurons across an entire brain. The results of c-Fos immunostaining are often quantified by counting the number of immunolabeled cells in a region of interest (ROI) ...Brain - Localization of functions - Research; Brain - Physiology - Research; Brain mapping - Research; Memory - Research; Mice as laboratory animals - Research; Brain activity; Immunohistochemical staining2016-05
2 Sharma, KapilAnalyzing the relationship between PDM2 and B-catenin proteins in human cancersTumorigenesis is promoted by the manipulation of several co-factors and pathways, in which PKM2 and P-catenin proteins play a significant role in a variety of cancers. New research states that these two hegemonic cancer proteins directly bind with each other and may provide a new angle for cance...Pyruvate kinase - Research; Tumorigensis - Research2016-04
3 Gilbert, AndrewComputational modeling of the rat hippocampus for improving neural stimulationNeural prostheses are used to restore some level of function to tissue damaged by disease. It is important to model and correctly identify the relationship between electrical stimulation and neural response to provide a framework for prosthetic stimulation. This work will show a struc...Neural stimulation - Research; Hippocampus (Brain) - Research; Memory - Research; Rats as laboratory animals - Research; Neural prosthetic2016-05
4 Bracken, KallieDefining learning: mystifying machine learning as a powerful tool in a data-driven worldUntil recently, the driving paradigm in software engineering has been to design applications for a predefined set of tasks. This approach, however, is quickly being dwarfed by data-driven applications which are designed to use knowledge and understanding to decide how they can best fulfill use...Machine learning - Case studies; Machine learning - Study and Teaching; Machine Learning - Technique2016-04
5 Hopkins, JacobDesign of a novel pediatric adaptive skiing systemAdaptive sports and recreational rehabilitation provide patients with experiences that cannot be achieved in a hospital or clinic. Of the many forms of adaptive equipment designed for children, only a few adaptive skiing systems are available and none are specifically designed for convenient adjusta...Skiing for people with disabilities - Research; Adaptive skiing technology; Adaptive sports; recreational rehabilitation2016-05
6 Matheson, KristofferDesign of a novel x-ray CT in situ experiment for imaging 3D deformation of aluminum foam materialsOpen-cell metallic foams show excellent potential for lightweight load-bearing structural applications, electrodes in energy-storage devices, biomedical implants, and heat exchangers, to name a few. A key aspect in efficient and streamlined deployment of aluminum foams for these applications lie...Foamed materials - Testing; Tomography - Research; Lightweight materials - Research; X-ray computed tomography; Aluminum foam materials; Load frame2016-04
7 Gajiwala, SnehalDetermining the variability of depressive brain circuitry among healthy subjects for deep brain stimulationDeep Brain Stimulation (DBS) is being evaluated to treat Treatment-Resistant Depression, though it has shown mixed results. We believe that variability within the fiber tracts of the brain may account for these outcome differences. In this study, we attempt to characterize this potential variation....Brain stimulation - Therapeutic use - Research; Depression, Mental - Treatment - Research; Deep brain stimulation; Depressive brain circuitry; Fiber tracts; Tractography2016-05
8 Luo, ShirleyDevelopment of a bioabsorbalbe active release antimicrobial coating for orthopedic implantsOrthopedic implantations often create an opportunity for biofilm-related infections to arise. Patients infected with biofilm must often undergo additional surgeries for repair or replacement, which puts them at a greater risk of osteomyelitis, sepsis, and other complications including death [17]. T...Orthopedic implants - Research; Anti-infective agents - Research; Staphyloccoccal infections - Prevention and control - Research; Antimicrobial coating; Staphylococcus aureus2016-05
9 Flach, BrianExamining the effects of whisker trimming on mouse brain cell growthHoxb8 microglia are a particular breed of scavenger cells in the brain which have been related to obsessive compulsive disorder (OCD)-like behavior among other behavioral disorders. These cells have been found to reach full maturity during a period of neurological development known as the critical ...Obsessive-compulsive disorder - Research; Microglia - Research; Mice as laboratory animals - Research; Whiskers; Scavenger cells; Hoxb8 microglia2016-04
10 Herbert-Voss, ArielGenerating audio mixtures using deep convolutional neural networksDeep neural networks have recently been used in a generative capacity to separate and convolve the content and style of two input images. This is done using a joint cost function during gradient descent that encodes information about style and content to iteratively calculate forward node activation...Computer sound processing; Computer music; Machine learning; Neural networks; Audio mixtures; Spectrograms; Split integer scaling2016-05
11 Luchinovich, AleksandrImproving measurement techniques of thin film solar cellsNew, innovative solar cell technologies such as CZTS, CdTe, and hybrid perovskite solar cells are constantly being pursued in order to deliver better cost per Watt performance. Moreover, cost and long term reliability(25 years or more) are important factors that are currently considered. The Scarpu...Solar cells - Testing; Thin films - Research; Electric power - Research; Thermal admittance spectroscopy2016-05
12 Goller, NicholasIterative game development: What goes into making an effective game and the lessons learned from making two gamesImagine you are told you have two semesters to make a game. You have a team of over ten people ready to help out. You even have the basic idea of what the game will be about. How hard can it be? Well, it is not that hard to make "a game" in two semesters. A competent coder can hack together a game...Computer games - Design2016-04
13 Wang, MinnaManaging limited ECG access in a clinical cardiac electrophysiology settingElectrocardiographic Imaging (ECGI) is a computational approach that seeks to reconstruct cardiac electrical activity with high precision from body surface ECGs by solving a numerical inverse problem. Though there have been great advancements in ECGI, there is still a need for progress in specific a...Electrocardiography - Research; Heart - Diseases - Diagnosis; Body surface potentials2016-05
14 Yehle, TobinMemoized parsing with derivativesDue to the computational complexity of parsing, constituent parsing is not preferred for tasks involving large corpora. However, the high similarity between sentences in natural language suggests that it is not necessary to pay the full computational price for each new sentence. In this work we p...Parsing (Computer grammar)2016-04
15 Singh, AnandPolyurethane molecular weight determination in catheters via gel permeation chromatographyAntimicrobial catheter extrusions are loaded with an antiseptic drug in order to help prevent catheter-related infections. Previous research has shown that polymer molecular weight (Mw) can be used to control drug loading levels. Polyurethane based resin and catheter shaft extrusion samples were cho...Catheters - Research; Bacterial diseases - Prevention; Drug loading levels; Gel permeation chromatography; Diffusion distance; Antimicrobial catheter extrustions; Catheter shaft extrusions; Bacterial Infections; MATLAB2016-05
16 Lietzke, StephanieRemoval of endotoxins from recombinant antithrombinEndotoxins (also known as lipopolysaccharides or ETs) are a pyrogenic byproduct of the breakdown of gram-negative bacterial cell-walls, such as E. coli. They cause fever and septic shock in humans, and are therefore highly regulated by the FDA and USP. ETs are a common contaminant in recombinant pr...Endotoxins - Research; Antithrombins - Therapeutic use; Sheep as laboratory animals - Research; endotoxin removal; Angiogenesis2016-04
17 Newton, JamesSocial behaviors in the developing Danio Rerio larva and adult DanionellaLarval zebrafish (Danio rerio) in most respects excel as an animal model in the study of neural networks, due to their small size and optical transparency. These traits permit optogenetic manipulation and live neuronal imaging of the entire brain, which when paired with behavioral analysis, have pot...Zebrafish (Zebra danio) - behavior; Zebrafish - embryology; Zebrafish - physiology2016-04
18 Clark, CalliStudying hypothetical electromagnetic earthquake precursors using a global finite-difference time-domain modelElectromagnetic (EM) precursors may be detectable by satellites and ground-based stations before large earthquakes strike and destroy entire cities. However, earthquakes are near impossible to predict as the physics of earthquake precursors is still poorly understood. This paper reports a global...earthquake prediction - Research; Seismology - Research; Earthquake hazard analysis; Earthquake precursors; Electromagnetic signals; Ionospheric physics; Finite-difference time-domain model2016-04
19 Delacenserie, JessicaUtilizing classroom technology to strengthen elementary educationThere is a disconnect in the current education system where there is an abundance of technology accessible to students but it is not being used in a way that enhances their education. The majority of software currently used in primary schools simply transfers books, homework assignments, etc. to mob...Education, Elementary; Computer-assisted instruction; Education - Effect of technological innovations on2016-05
20 Davidson, OliviaUtilizing synthetic biology to improve platelet transfusion outcomesPlatelets are essential to blood clotting. Due to a high risk of bacterial infection, donor platelets have short shelf -lives. As a result, being able to maintain a constant supply of platelets in vitro would be clinically valuable. This could be accomplished by using synthetic biology to guide stem...Blood platelets - Transfusion - Research; Stem cells - Therapeutic use; Synthetic biology; Hematopoietic stem cells; Erthropoientin2016-05
21 Palmieri, NikoleValidation of a nonlinear optimization algorithm for reconstruction of diffused imagesLiving tissue is a diffusive light-scattering medium, preventing traditional fluorescence microscopy from being used as a diagnostic imaging modality. To determine microscopy from being used as a diagnostic imaging modality. To determine whether the nonlinear optimization algorithm developed for C...Diagnostic imaging; Mathematical optimization; Image processing; Diffusion distance; Computational Cannula Microscopy; Nonlinear optimization; MATLAB2016-04
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