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CreatorTitleDescriptionSubjectDate
26 Gerig, GuidoAutomatic corpus callosum segmentation using a deformable active Fourier contour modelThe corpus callosum (CC) is a structure of interest in many neuroimaging studies of neuro-developmental pathology such as autism. It plays an integral role in relaying sensory, motor and cognitive information from homologous regions in both hemispheres. We have developed a framework that allows auto...2012-01-01
27 Gerig, GuidoEarly postnatal development of corpus callosum and corticospinal white matter assessed with quantitative tractographyBACKGROUND AND PURPOSE: The early postnatal period is perhaps the most dynamic phase of white matter development. We hypothesized that the early postnatal development of the corpus callosum and corticospinal tracts could be studied in unsedated healthy neonates by using novel approaches to diffusion...2007-01-01
28 Gerig, GuidoStatistical shape analysis of Multi-Object complexesAn important goal of statistical shape analysis is the discrimination between populations of objects, exploring group differences in morphology not explained by standard volumetric analysis. Certain applications additionally require analysis of objects in their embedding context by joint statistical...2007-01-01
29 Pascucci, ValerioCharacterization and modeling of PIDX parallel I/O for performance optimizationParallel I/O library performance can vary greatly in re- sponse to user-tunable parameter values such as aggregator count, file count, and aggregation strategy. Unfortunately, manual selection of these values is time consuming and dependent on characteristics of the target machine, the underlying fi...2013-01-01
30 Gerig, GuidoSubcortical structure segmentation using probabilistic atlas priorsThe segmentation of the subcortical structures of the brain is required for many forms of quantitative neuroanatomic analysis. The volumetric and shape parameters of structures such as caudate are employed to characterize a disease or its evolution. This paper presents our fully automatic segmentati...2007-01-01
31 Planelles, VicenteAn HIV-encoded antisense long non-coding RNA epigenetically regulates viral transcriptionThe abundance of long non-coding RNAs (lncRNAs) and their wide range of functional roles in human cells are fast becoming realized. Importantly, lncRNAs have been identified as epigenetic modulators and consequently play a pivotal role in the regulation of gene expression. A human immunodeficiency v...2014-01-01
32 Gerig, GuidoSegmentation of serial MRI of TBI patients using personalized atlas construction and topological change estimationTraumatic brain injury (TBI) due to falls, car accidents, and warfare affects millions of people annually. Determining personalized therapy and assessment of treatment efficacy can substantially benefit from longitudinal (4D) magnetic resonance imaging (MRI). In this paper, we propose a method for s...2012-01-01
33 Gerig, GuidoDiscrimination analysis using Multi-object statistics of shape and poseA main focus of statistical shape analysis is the description of variability of a population of geometric objects. In this paper, we present work towards modeling the shape and pose variability of sets of multiple objects. Principal geodesic analysis (PGA) is the extension of the standard technique ...2007-01-01
34 Gerig, GuidoUnbiased diffeomorphic atlas construction for computational anatomyConstruction of population atlases is a key issue in medical image analysis, and particularly in brain mapping. Large sets of images are mapped into a common coordinate system to study intra-population variability and inter-population differences, to provide voxel-wise mapping of functional sites, a...2004-01-01
35 Macleod, Robert S.Identification and acute targeting of gaps in atrial ablation lesion sets using a real-time magnetic resonance imaging systemBackground-Radiofrequency ablation is routinely used to treat cardiac arrhythmias, but gaps remain in ablation lesion sets because there is no direct visualization of ablation-related changes. In this study, we acutely identify and target gaps using a real-time magnetic resonance imaging (RT-MRI) sy...2012-01-01
36 Gerig, GuidoComputational anatomy to assess longitudinal trajectory of brain growthThis paper addresses the challenging problem of statistics on images by describing average and variability. We describe computational anatomy tools for building 3-D and spatio-temporal 4-D atlases of volumetric image data. The method is based on the previously published concept of unbiased atlas bui...2006-01-01
37 Gerig, GuidoAnalyzing imaging biomarkers for traumatic brain injury using 4D modeling of longitudinal MRIQuantitative imaging biomarkers are important for assessment of impact, recovery and treatment efficacy in patients with traumatic brain injury (TBI). To our knowledge, the identification of such biomarkers characterizing disease progress and recovery has been insufficiently explored in TBI due to d...2013-01-01
38 Gerig, GuidoModeling longitudinal MRI changes in populations using a localized, information-theoretic measure of contrastLongitudinal MR imaging during early brain development provides important information about growth patterns and the development of neurological disorders. We propose a new framework for studying brain growth patterns within and across populations based on MRI contrast changes, measured at each time ...2013-01-01
39 Gerig, GuidoMeasures for validation of DTI tractographyThe evaluation of analysis methods for diffusion tensor imaging (DTI) remains challenging due to the lack of gold standards and validation frameworks. Significant work remains in developing metrics for comparing fiber bundles generated from streamline tractography. We propose a set of volumetric and...2012-01-01
40 Gerig, GuidoMultivariate longitudinal statistics for neonatal-pediatric brain tissue developmentThe topic of studying the growth of human brain development has become of increasing interest in the neuroimaging community. Cross-sectional studies may allow comparisons between means of different age groups, but they do not provide a growth model that integrates the continuum of time, nor do they ...2008-01-01
41 Pascucci, ValerioExploring power behaviors and trade-offs of in-situ data analyticsAs scientific applications target exascale, challenges related to data and energy are becoming dominating concerns. For example, coupled simulation workflows are increasingly adopting in-situ data processing and analysis techniques to address costs and overheads due to data movement and I/O. However...2013-01-01
42 Gerig, GuidoChanges of MR and DTI appearance in early human brain developmentUnderstanding myelination in early brain development is of clinical importance, as many neurological disorders have their origin in early cerebral organization and maturation. The goal of this work is to study a large neonate database acquired with standard MR imagery to illuminate effects of early ...2010-01-01
43 Gerig, GuidoModeling 4D changes in pathological anatomy using domain adaptation: analysis of TBI imaging using a tumor databaseAnalysis of 4D medical images presenting pathology (i.e., lesions) is significantly challenging due to the presence of complex changes over time. Image analysis methods for 4D images with lesions need to account for changes in brain structures due to deformation, as well as the formation and deletio...2013-01-01
44 Pascucci, ValerioThe natural Helmholtz-Hodge decomposition for open-boundary flow analysisThe Helmholtz-Hodge decomposition (HHD), which describes a flow as the sum of an incompressible, an irrotational, and a harmonic flow, is a fundamental tool for simulation and analysis. Unfortunately, for bounded domains, the HHD is not uniquely defined, traditionally, boundary conditions are impose...2014-01-01
45 Gerig, GuidoImage registration driven by combined probabilistic and geometric descriptorsDeformable image registration in the presence of considerable contrast dierences and large-scale size and shape changes represents a signicant challenge for image registration. A representative driving application is the study of early brain development in neuroimaging, which requires co-registratio...2010-01-01
46 Gerig, GuidoEfficient probabilistic and geometric anatomical mapping using particle mesh approximation on GPUsDeformable image registration in the presence of considerable contrast differences and large size and shape changes presents significant research challenges. First, it requires a robust registration framework that does not depend on intensity measurements and can handle large nonlinear shape variati...2011-01-01
47 Pascucci, ValerioExploring performance data with boxfishThe growth in size and complexity of scaling applications and the systems on which they run pose challenges in analyzing and improving their overall performance. With metrics coming from thousands or millions of processes, visualization techniques are necessary to make sense of the increasing amount...2012-01-01
48 Gerig, Guido3D tensor normalization for improved accuracy in DTI tensor registration methodsThis paper presents a method for normalization of diffusion tensor images (DTI) to a xed DTI template, a pre-processing step to improve the performance of full tensor based registration methods. The proposed method maps the individual tensors of the subject image in to the template space based on ma...2012-01-01
49 Kuhlman, BrianPHD EntrepreneurThe idea for this speech began when my friends and family started asking what I would do after graduating with my PhD in psychology. Folks tended to get a bit confused when I replied that my plan is to start a business. You don't need a PhD to do that! It's true. The path leading from PhD to Entrepr...entrepreneur; PhD; doctoral; industry; academia2013-05-03
50 Gerig, GuidoA structural MRI study of human brain development from birth to two yearsBrain development in the first 2 years after birth is extremely dynamic and likely plays an important role in neurodevelopmental disorders, including autism and schizophrenia. Knowledge regarding this period is currently quite limited. We studied structural brain development in healthy subjects from...2008-01-01
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