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| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
 | Beckerle, Mary C. | Activation-dependent redistribution of the adhesion plaque protein, talin, in intact human platelets | Talin is a high molecular weight protein localized at adhesion plaques in fibroblasts. It binds vinculin and integrin and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton. | Talin | 1989 |
| 2 |
 | Beckerle, Mary C. | Analysis of the roles of microtubules and actin in erythrophore intracellular motility | The Holocentrus erythrophore, a red pigment cell, represents a model system for the study of organized intracellular transport. We have investigated the possibility that microtubules and actin are integral components of the pigment translocating motility machine. | Actin; Actomyosin; Erythrophore; Pigment | 1983 |
| 3 |
 | Jorgensen, Erik | Axons break in animals lacking B-spectrin | Axons and dendrites can withstand acute mechanical strain despite their small diameter. In this study, we demonstrate that β-spectrin is required for the physical integrity of neuronal processes in the nematode Caenorhabditis elegans. Axons in β-spectrin mutants spontaneously break. | 2007 | |
| 4 |
 | Bastiani, Michael | Axons break in animals lacking β-spectrin | Axons and dendrites can withstand acute mechanical strain despite their small diameter. In this study, we demonstrate that β-spectrin is required for the physical integrity of neuronal processes in the nematode Caenorhabditis elegans. Axons in β-spectrin mutants spontaneously break. | Mutants; Dendrites; Morphology | 2007 |
| 5 |
 | Baehr, Wolfgang | Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter | We have previously shown that postnatal expression of the viral oncoprotein SV40 T antigen in rod photoreceptors (transgene MOT1), at a time when retinal cells have withdrawn from the mitotic cycle, leads to photoreceptor cell death (Al-Ubaidi et al., 1992. Proc. Natl. Acad. Sci. USA. 89:1194-1198).... | Simian virus 40; Retinol-Binding Proteins; Promoter Regions (Genetics) | 1992 |
| 6 |
 | Beckerle, Mary C. | Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeleton | LIM domains are present in a number of proteins including transcription factors, a protooncogene product, and the adhesion plaque protein zyxin. The LIM domain exhibits a characteristic arrangement of cysteine and histidine residues and represents a novel zinc binding sequence (Michelsen et al., ... | Zyxin; Cysteine-rich proteins; cCRP; Actin; LIM domains | 1994 |
| 7 |
 | Olivera, Baldomero M. | Block of Shaker K+ channels by ĸ-conotoxin PVIIA is state dependent | ĸ-conotoxin PVIIA is the first conotoxin known to interact with voltage-gated potassium channels by inhibiting Shaker-mediated currents. We studied the mechanism of inhibition and concluded that PVIIA blocks the ion pore with a 1:1 stoichiometry and that binding to open or closed channels is very d... | Conotoxins; k-conotoxin PVIIA; Potassium channel blockers; Shaker K+ channels | 1999 |
| 8 |
 | Jorgensen, Erik; Schuske, Kimberly R. | CAPS and syntaxin dock dense core vesicles to the plasma membrane in neurons | Docking to the plasma membrane prepares vesicles for rapid release. Here, we describe a mechanism for dense core vesicle docking in neurons. In Caenorhabditis elegons motor neurons, dense core vesicles dock at the plasma membrane but are excluded from active zones at synapses. | 2008 | |
| 9 |
 | Beckerle, Mary C.; Clark, Kathleen A. | Conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans | We describe here the molecular and functional characterization of the Caenorhabditis elegans unc-97 gene, whose gene product constitutes a novel component of muscular adherens junctions. UNC-97 and homologues from several other species define the PINCH family, a family of LIM proteins whose modula... | LIM domains; Caenorhabditis elegans; UNC-97; Adherens junction; Touch neuron; Muscle development | 1999 |
| 10 |
 | Normann, Richard A. | Control of retinal sensitivity. I. Light and dark adaptation of vertebrate rods and cones | Rods and cones in Necturus respond with graded hyperpolarization to test flashes spanning about 3.5 log units of intensity. Steady background levels hyperpolarize the rods, and the rod responses become progressively smaller as background level is increased. In cones, higher background levels reduce... | Retina;Light and Dark Adaptation; Recepters; Bipolars; Ganglion Cells | 1974 |
| 11 |
 | Beckerle, Mary C. | CRP1, a LIM domain protein implicated in muscle differentiation, interacts with α-actinin | Members of the cysteine-rich protein (CRP) family are LIM domain proteins that have been implicated in muscle differentiation. One strategy for defining the mechanism by which CRPs potentiate myogenesis is to characterize the repertoire of CRP binding partners. | CRP1; Cysteine-rich proteins; Actinin; Protein-protein interactions; LIM domains | 1997 |
| 12 |
 | Beckerle, Mary C. | Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated platelets | Activation of blood platelets triggers a series of responses leading to the formation and retraction of blood clots. Among these responses is the establishment of integrin-mediated transmembrane connections between extracellular matrix components and the actin cytoskeleton of the platelet. | Actin; GPIIb-IIIa | 1993 |
| 13 |
 | Beckerle, Mary C.; Hoffman, Laura M.; Yoshigi, Masaaki | Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling | Focal adhesions are specialized regions of the cell surface where integrin receptors and associated proteins link the extracellular matrix to the actin cytoskeleton. To define the cellular role of the focal adhesion protein zyxin, we characterized the phenotype of fibroblasts in which the zyxin gene... | Zyxin; Actin; Mena/VASP | 2006 |
| 14 |
 | Beckerle, Mary C. | Identification of a new protein localized at sites of cell-substrate adhesion | A new protein found at sites of cellsubstrate adhesion has been identified by analysis of a nonimmune rabbit serum. By indirect immunofluorescence this serum stains focal contacts (adhesion plaques) and the associated termini of actin filament bundles in cultured chicken cells. | Actin; Nonimmune rabbit serum; Polypeptide | 1986 |
| 15 |
 | Beckerle, Mary C.; Clark, Kathleen A. | Integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1 | Cell adhesion and migration are dynamic pro- cesses requiring the coordinated action of multiple signaling pathways, but the mechanisms underlying signal integration have remained elusive. Drosophila embryonic dorsal closure (DC) requires both integrin function and c-Jun amino-terminal kinase (JNK) ... | Epithelial sheets; PINCH | 2004 |
| 16 |
 | Beckerle, Mary C. | Interaction between zyxin and α-actinin | Zyxin is an 82-kD protein first identified as a component of adhesion plaques and the termini of stress fibers near where they associate with the cytoplasmic face of the adhesive membrane. We report here that zyxin interacts with the actin cross-linking protein α-actinin. | Zyxin; Actinin; Actin | 1992 |
| 17 |
 | Baehr, Wolfgang | Light-dependent changes in G-protein binding to ROS membranes in intact Bufo retinas | Light-dependent changes in the binding of G-protein were analyzed in outer segment disk membranes obtained from photoreceptors of the toad (Bufo marinus) retina. Isolated, intact retinas, incubated in oxygenated Ringer's solution at 23 +/- 1 degree C, were subjected to various conditions of illumina... | Centrifugation, Density Gradient; Membranes; Adaptation, Physiological | 1986 |
| 18 |
 | Beckerle, Mary C.; Yoshigi, Masaaki; Hoffman, Laura M.; Yost, H. Joseph | Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement | Organs and tissues adapt to acute or chronic mechanical stress by remodeling their actin cytoskeletons. Cells that are stimulated by cyclic stretch or shear stress in vitro undergo bimodal cytoskeletal responses that include rapid reinforcement and gradual reorientation of actin stress fibers; howev... | Zyxin; Actin | 2005 |
| 19 |
 | Beckerle, Mary C. | Microinjected fluorescent polystyrene beads exhibit saltatory motion in tissue culture cells | Microinjected 0.26-um fluorescent, carboxylated microspheres were found to display classical saltatory motion in tissue culture cells . The movement of a given particle was characterized by a discontinuous velocity distribution and was unaffected by the activity of adjacent particles. | Organelles; Microscopy; Proteins | 1984 |
| 20 |
 | Jorgensen, Erik | Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2 | Synaptic transmission depends on clathrin-mediated recycling of synaptic vesicles (SVs). How select SV proteins are targeted for internalization has remained elusive. Stonins are evolutionarily conserved adaptors dedicated to endocytic sorting of the SV protein synaptotagmin. Our data identify the m... | 2007 | |
| 21 |
 | Beckerle, Mary C. | Molecular dissection of zyxin function reveals its involvement in cell motility | Spatially controlled actin filament assembly is critical for numerous processes, including the vectorial cell migration required for wound healing, cell-mediated immunity, and embryogenesis. One protein implicated in the regulation of actin assembly is zyxin, a protein concentrated at sites where t... | Zyxin; Actinin; Ena/VASP | 1999 |
| 22 |
 | Jorgensen, Erik | Mutations in synaptojanin disrupt synaptic vesicle recycling | Synaptojanin is a polyphosphoinositide phosphatase that is found at synapses and binds to proteins implicated in endocytosis. For these reasons, it has been proposed that synaptojanin is involved in the recycling of synaptic vesicles. Here, we demonstrate that the unc-26 gene encodes the Caenorhab... | 2000 | |
| 23 |
 | Jorgensen, Erik | Mutations in β-spectrin disrupt axon outgrowth and sarcomere structure | B-Spectrin is a major component of the membrane skeleton, a structure found at the plasma membrane of most animal cells. B-Spectrin and the membrane skeleton have been proposed to stabilize cell membranes, generate cell polarity, or localize specific membrane proteins. We demonstrate that the Caen... | 2000 | |
| 24 |
 | Baehr, Wolfgang | Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye | Visual sensation in vertebrates is triggered when light strikes retinal photoreceptor cells causing photoisomerization of the rhodopsin chromophore 11-cis-retinal to all-trans-retinal. The regeneration of preillumination conditions of the photoreceptor cells requires formation of 11-cis-retinal in t... | Microscopy, Fluorescence; Visual Perception; Membrane Proteins | 2004 |
| 25 |
 | Beckerle, Mary C. | Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus | Integrin-dependent cell adhesion to specific extracellular matrix molecules has been demonstrated to trigger dramatic changes in gene expression that can affect cell fate. However, little is understood about the molecular mechanism by which events at sites of cell-substratum adhesion are communicate... | Zyxin; Cytosol; Nuclear export signal | 1997 |