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| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
 | Kerber, Richard A. | A genome-wide study replicates linkage of 3p22-24 to extreme longevity in humans and identifies possible additional loci | Background: Although there is abundant evidence that human longevity is heritable, efforts to map loci responsible for variation in human lifespan have had limited success. Methodology/Principal Findings: We identified individuals from a large multigenerational population database (the Utah Populati... | 2012-01-01 | |
| 2 |
 | Dale, Colin | A novel human-infection-derived bacterium provides insights into the evolutionary origins of mutualistic insect-bacterial symbioses | Despite extensive study, little is known about the origins of the mutualistic bacterial endosymbionts that inhabit approximately 10% of the world's insects. In this study, we characterized a novel opportunistic human pathogen, designated ‘‘strain HS,'' and found that it is a close relative of th... | 2012-01-01 | |
| 3 |
 | Ehleringer, James R. ; Cerling, Thure E. | Aberrant water homeostasis detected by stable isotope analysis | While isotopes are frequently used as tracers in investigations of disease physiology (i.e., 14C labeled glucose), few studies have examined the impact that disease, and disease-related alterations in metabolism, may have on stable isotope ratios at natural abundance levels. The isotopic composition... | 2010-07-21 | |
| 4 |
 | Hughes, Kelly T. | ATPase-Independent Type-III Protein Secretion in Salmonella enterica | Type-III protein secretion systems are utilized by gram-negative pathogens to secrete building blocks of the bacterial flagellum, virulence effectors from the cytoplasm into host cells, and structural subunits of the needle complex. The flagellar type-III secretion apparatus utilizes both the energy... | 2014-01-01 | |
| 5 |
 | Bernstein, Paul S.; Zabriskie, Norman A.; Zhang, Kang | CFH Y402H Confers similar risk of soft Drusen and both forms of advanced AMD | BACKGROUND: Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment in the developed world. The two forms of advanced AMD, geographic atrophy and neovascular AMD, represent different pathological processes in the macula that lead to loss of central vision. S... | 2005 | |
| 6 |
 | Jorde, Lynn B. | Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: A report from the Childrens Oncology Group | Background: The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understood. EWS/FLI and related EWS/ETS chimeras upregulate numerous gene targets via promoter-based GGAA-microsatellite response elements. These microsatellites are highly polymorphic in humans, and prelimina... | 2014-01-01 | |
| 7 |
 | Tasdizen, Tolga; Jones, Bryan W.; Whitaker, Ross T. | Computational framework for ultrastructural mapping of neural circuitry | Circuitry mapping of metazoan neural systems is difficult because canonical neural regions (regions containing one or more copies of all components) are large, regional borders are uncertain, neuronal diversity is high, and potential network topologies so numerous that only anatomical ground truth c... | 2009 | |
| 8 |
 | Thomas, Kirk R. | Cytochrome P450 2B diversity and dietary novelty in the herbivorous, desert woodrat (Neotoma lepida) | Detoxification enzymes play a key role in plant-herbivore interactions, contributing to the on-going evolution of ecosystem functional diversity. Mammalian detoxification systems have been well studied by the medical and pharmacological industries to understand human drug metabolism; however, little... | 2012-01-01 | |
| 9 |
 | Planelles, Vicente | Differential effects of Vpr on single-cycle and spreading HIV-1 infections in CD4 + T-cells and dendritic cells | The Vpr protein of human immunodeficiency virus type 1 (HIV-1) contributes to viral replication in non-dividing cells, specifically those of the myeloid lineage. However, the effects of Vpr in enhancing HIV-1 infection in dendritic cells have not been extensively investigated. Here, we evaluated the... | 2012-01-01 | |
| 10 |
 | Clayton, Dale H. | Ecoimmunity in Darwin's finches: invasive parasites trigger acquired immunity in the medium ground finch (Geospiza fortis) | Invasive parasites pose a serious threat to native animal populations, because hosts with no history of exposure may lack effective immune defenses. Invasive parasites are a particular threat to small, island populations [1,2]. For example, introduced malaria (Plasmodium relictum) has exacerbated t... | Darwins finches; Ecoimmunity; Acquired immunity; Medium ground finch; Geospiza fortis; Invasive parasites; Novel parasites; Poxvirus avium; Nest flies; Philornis downsi | 2010-01-06 |
| 11 |
 | Adler, Frederick R. | Effect of 1918 PB1-F2 expression on influenza A virus infection kinetics | Relatively little is known about the viral factors contributing to the lethality of the 1918 pandemic, although its unparalleled virulence was likely due in part to the newly discovered PB1-F2 protein. This protein, while unnecessary for replication, increases apoptosis in monocytes, alters viral po... | 2011 | |
| 12 |
| Adler, Frederick R. | Effect of 1918 PB1-F2 expression on influenza A virus infection kinetics | Abstract Relatively little is known about the viral factors contributing to the lethality of the 1918 pandemic, although its unparalleled virulence was likely due in part to the newly discovered PB1-F2 protein. This protein, while unnecessary for replication, increases apoptosis in monocytes, alter... | 2011 | |
| 13 |
 | Hughes, Kelly T. | The effect of cell growth phase on the regulatory cross-talk between flagellar and Spi1 virulence gene expression | The flagellar regulon controls Salmonella biofilm formation, virulence gene expression and the production of the major surface antigen present on the cell surface: flagellin. At the top of a flagellar regulatory hierarchy is the master operon, flhDC, which encodes the FlhD4C2 transcriptional complex... | 2014-01-01 | |
| 14 |
 | Hughes, Kelly T. | The effects of codon context on in vivo translation speed | We developed a bacterial genetic system based on translation of the his operon leader peptide gene to determine the relative speed at which the ribosome reads single or multiple codons in vivo. Low frequency effects of so-called ‘‘silent'' codon changes and codon neighbor (context) effects could... | 2014-01-01 | |
| 15 |
 | Yaffe, Joanne | Empty reviews: a description and consideration of cochrane systematic reviews with no included studies | Background: There is no specific guidance for the reporting of Cochrane systematic reviews that do not have studies eligible for inclusion. As a result, the reporting of these so-called ‘‘empty reviews'' may vary across reviews. This research explores the incidence of empty systematic reviews in... | 2012-01-01 | |
| 16 |
 | Jarrard, Richard D. | Exceptionally preserved jellyfishes from the Middle Cambrian | Cnidarians represent an early diverging animal group and thus insight into their origin and diversification is key to understanding metazoan evolution. Further, cnidarian jellyfish comprise an important component of modern marine planktonic ecosystems. Here we report on exceptionally preserved cnida... | Jellyfishes; metazoan evolution; jellyfish fossils; marjum formation; Utah; middle cambrian | 2007-10-31 |
| 17 |
 | Jorgensen, Erik; Carroll, Dana | Gene activation using FLP recombinase in C. elegans | The FLP enzyme catalyzes recombination between specific target sequences in DNA. Here we use FLP to temporally and spatially control gene expression in the nematode C. elegans. Transcription is blocked by the presence of an "off cassette" between the promoter and the coding region of the desired pro... | 2008 | |
| 18 |
 | Clayton, Dale H.; Rogers, Alan R. | Genetic analysis of lice supports direct contact between modern and archaic humans | Parasites can be used as unique markers to investigate host evolutionary history, independent of host data. Here we show that modern human head lice, Pediculus humanus, are composed of two ancient lineages, whose origin predates modern Homo sapiens by an order of magnitude (ca. 1.18 million years). | Pediculus humanus; Head lice; Molecular phylogeny; Phthirus | 2004 |
| 19 |
 | Shapiro, Michael D. | Genetic architecture of parallel armor plate reduction in threespine sticklebacks | How many genetic changes control the evolution of new traits in natural populations? Are the same genetic changes seen in cases of parallel evolution? Despite long-standing interest in these questions, they have been difficult to address, particularly in vertebrates. We have analyzed the genetic bas... | Genetic changes; Plate number; Genetic mapping | 2004 |
| 20 |
 | Sekercioglu, Cagan | Mapping functional traits: comparing bundance and presence-absence estimates at large spatial scales | Efforts to quantify the composition of biological communities increasingly focus on functional traits. The composition of communities in terms of traits can be summarized in several ways. Ecologists are beginning to map the geographic distribution of trait-based metrics from various sources of data,... | 2012-01-01 | |
| 21 |
 | Sekercioglu, Cagan | Measuring the meltdown: drivers of global amphibian extinction and decline | Habitat loss, climate change, over-exploitation, disease and other factors have been hypothesised in the global decline of amphibian biodiversity. However, the relative importance of and synergies among different drivers are still poorly understood. We present the largest global analysis of roughly ... | 2008-01-01 | |
| 22 |
 | Kerber, Richard A. | Mitochondrial genomic analysis of late onset alzheimers disease reveals protective haplogroups H6A1A/H6A1B: the Cache County study on memory in aging | Background: Alzheimer's disease (AD) is the most common cause of dementia and AD risk clusters within families. Part of the familial aggregation of AD is accounted for by excess maternal vs. paternal inheritance, a pattern consistent with mitochondrial inheritance. The role of specific mitochondrial... | 2012-01-01 | |
| 23 |
 | Rogers, Alan R.; Jorde, Lynn B. | Modeling the amplification dynamics of human Alu retrotransposons | Retrotransposons have had a considerable impact on the overall architecture of the human genome. Currently, there are three lineages of retrotransposons (Alu, L1, and SVA) that are believed to be actively replicating in humans. While estimates of their copy number, sequence diversity, and levels of ... | Retrotransposons; Amplification dynamics; Mutation; Human-chimpanzee divergence | 2005 |
| 24 |
 | Voth, Gregory Alan | Multiscale coarse-graining of the protein energy landscape | A variety of coarse-grained (CG) models exists for simulation of proteins. An outstanding problem is the construction of a CG model with physically accurate conformational energetics rivaling all-atom force fields. In the present work, atomistic simulations of peptide folding and aggregation equilib... | 2010-06-24 | |
| 25 |
 | Jorgensen, Erik | Open syntaxin docks synaptic vesicles | Synaptic vesicles dock to the plasma membrane at synapses to facilitate rapid exocytosis. Docking was originally proposed to require the soluble N-ethylmaleimide-sensitive fusion attachment protein receptor (SNARE) proteins; however, perturbation studies suggested that docking was independent of the... | 2007 |