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Creator | Title | Description | Subject | Date |
| 1 |
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Hawkes, Kristen | A reappraisal of grandmothering and natural selection | Kachel et al. [1] conclude from simulations of their agent-based model that fitness benefits from helpful grandmothers do not select for increased longevity. We studied their assumptions and model, ran further simulations and found flaws that are fatal to their test. Here, we explain four problems a... | | 2011-01-01 |
| 2 |
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Gerig, Guido | Abnormal brain synchrony in down syndrome | Down Syndrome is the most common genetic cause for intellectual disability, yet the pathophysiology of cognitive impairment in Down Syndrome is unknown. We compared fMRI scans of 15 individuals with Down Syndrome to 14 typically developing control subjects while they viewed 50 min of cartoon video c... | | 2013-01-01 |
| 3 |
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Hawkes, Kristen | Affluent hunters? Some comments in light of the Alyawara case | Our recent analysis (O'Connell and Hawkes in press) of plant food collecting among the Alyawara, a central Australian hunting group, shows that the cost of subsistence is sometimes quite high, far higher than the current conven. tional wisdom regarding hunters would suggest. We infer from available ... | | 1981-01-01 |
| 4 |
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Hawkes, Kristen | Age-related decline in ovarian follicle stocks differ between chimpanzee (Pan troglodytes) and humans | Similarity in oldest parturitions in humans and great apes suggests that we maintain ancestral rates of ovarian aging. Consistent with that hypothesis, previous counts of primordial follicles in postmortem ovarian sections from chimpanzees (Pan troglodytes) showed follicle stock decline at the same ... | | 2015-01-01 |
| 5 |
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Gerig, Guido | Asymmetrical ventricular enlargement in Parkinsons Disease | Background-A recent case report suggested the presence of asymmetrical lateral ventricular enlargement associated with motor asymmetry in Parkinson's disease (PD). The current study explored these associations further. Methods-Magnetic resonance imaging (3T) scans were obtained on 17 PD and 15 healt... | Structural magnetic resonance imaging; Semi-automatic segmentation; Lateral ventricular volume; Motor asymmetry; Parkinson's disease | 2007-01-01 |
| 6 |
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Gerig, Guido | Automatic and robust computation of 3D medial models incorporating object variability | Abstract. This paper presents a novel processing scheme for the automatic and robust computation of a medial shape model which represents an object population with shape variability. The sensitivity of medial descriptions to object variations and small boundary perturbations are fundamental problems... | | 2003-01-01 |
| 7 |
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Hawkes, Kristen | Brief communication: adrenal androgens and aging: female chimpanzees (Pan troglodytes) compared with women | Ovarian cycling continues to similar ages in women and chimpanzees yet our nearest living cousins become decrepit during their fertile years and rarely outlive them. Given the importance of estrogen in maintaining physiological systems aside from fertility, similar ovarian aging in humans and chimpa... | Dehydroepiandrosterone sulfate; Senescence; Aging rates; Human longevity | 2013-01-01 |
| 8 |
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Gerig, Guido | Diffusion imaging quality control via entropy of principal direction distribution | Diffusion MR imaging has received increasing attention in the neuroimaging community, as it yields new insights into the microstructural organization of white matter that are not available with conventional MRI techniques. While the technology has enormous potential, diffusion MRI suffers from a uni... | Diffusion magnetic resonance imaging; Diffusion tensor imaging; Quality assessment; Entropy | 2013-01-01 |
| 9 |
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Hawkes, Kristen | Evaluating grandmother effects | Women who have outlived child-bearing have long been described as post-reproductive. But contributions they make to the survival or fertility of their descendants enhance the reproduction of their genes. Consequently natural selection affects this characteristic stage of human life history. Grandmot... | Human life history; Historical demography; Human longevity | 2009-01-01 |
| 10 |
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Gerig, Guido | Fiber tract-oriented statistics for quantitative diffusion tensor MRI analysis | Diffusion tensor imaging (DTI) has become the major modality to study properties of white matter and the geometry of fiber tracts of the human brain. Clinical studies mostly focus on regional statistics of fractional anisotropy (FA) and mean diffusivity (MD) derived from tensors. Existing analysis t... | Diffusion tensor interpolation, Diffusion tensor statistics, DTI analysis, Fiber tract modeling | 2006-01-01 |
| 11 |
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Gerig, Guido | Frontolimbic neural circuitry at 6 months predicts individual differences in joint attention at 9 months | Elucidating the neural basis of joint attention in infancy promises to yield important insights into the development of language and social cognition, and directly informs developmental models of autism. We describe a new method for evaluating responding to joint attention performance in infancy tha... | Joint attention; DTI; Amygdala; Uncinate fasciculus; Infancy; Development | 2013-01-01 |
| 12 |
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Hawkes, Kristen | The grandmother effect | Why do women live long past the age of child-bearing? Contrary to common wisdom, this phenomenon is not new, and is not due to support for the elderly. Rather, grannies have a lot to offer their grandchildren. | | 2004-01-01 |
| 13 |
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Hawkes, Kristen | Grandmother effects, heterogeneity, and the evolution of human aging: guidance from human-chimpanzee comparisons | In the first paper to present formal theory explaining that senescence is a consequence of natural selection, W. D. Hamilton concluded that human postmenopausal longevity results from the contributions of ancestral grandmothers to the reproduction of their relatives. A grandmother hypothesis, subseq... | Evolution of senescence; Heterogeneity of frailty; Human life history; Menopause; Human aging | 2010-01-01 |
| 14 |
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Hawkes, Kristen | Grandmothers and the evolution of human longevity: a review of findings and future directions | Women and female great apes both continue giving birth into their forties, but not beyond. However humans live much longer than other apes do.[1] Even in hunting and gathering societies, where the mortality rate is high, adult life spans average twice those of chimpanzees, which become decrepit duri... | Life history evolution; Senescence; Cooperative child rearing; Infant psychology; Male-male competition | 2013-01-01 |
| 15 |
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Gerig, Guido | Group analysis of DTI fiber tract statistics with application to neurodevelopment | Diffusion tensor imaging (DTI) provides a unique source of information about the underlying tissue structure of brain white matter in vivo including both the geometry of major fiber bundles as well as quantitative information about tissue properties represented by derived tensor measures. This paper... | Diffusion tensor imaging; Registration; Tract modeling; Neurodevelopment; Statistical modeling | 2009-01-01 |
| 16 |
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Hawkes, Kristen | Human actuarial aging increases faster when background death rates are lower: a consequence of differential heterogeneity? | Many analyses of human populations have found that age-specific mortality rates increase faster across most of adulthood when overall mortality levels decline. This contradicts the relationship often expected from Williams' classic hypothesis about the effects of natural selection on the evolution o... | Frailty; Gompertz; Mortality rate doubling times; Ricklefs' omega; Strehler-Mildvan correlations; Weibull | 2011-01-01 |
| 17 |
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Gerig, Guido | Hypothesis testing with nonlinear shape models | We present a method for two-sample hypothesis testing for statistical shape analysis using nonlinear shape models. Our approach uses a true multivariate permutation test that is invariant to the scale of different model parameters and that explicitly accounts for the dependencies between variables. ... | | 2005-01-01 |
| 18 |
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Hawkes, Kristen | Increased longevity evolves from grandmothering | Postmenopausal longevity may have evolved in our lineage when ancestral grandmothers subsidized their daughters' fertility by provisioning grandchildren, but the verbal hypothesis has lacked mathematical support until now. Here, we present a formal simulation in which life spans similar to those of ... | Human evolution; Life history; Sexual conflict | 2012-01-01 |
| 19 |
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Hawkes, Kristen | Kin selection and culture | This paper argues that while the discriminations organizing human action are cultural, and kinship in anthropology is not equivalent to genetic relatedness, the theory of kin selection developed in evolutionary biology can tell us a great deal about human social organization. Data on garden assistan... | | 1983-01-01 |
| 20 |
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Hawkes, Kristen | Mortality and fertility rates in humans and chimpanzees: how within-species variation complicates cross-species comparisons | A grandmother hypothesis may explain why humans evolved greater longevity while continuing to end female fertility at about the same age as do the other great apes. With that grandmother hypothesis in mind, we sought to compare age-specific mortality and fertility rates between humans and chimpanzee... | | 2009-01-01 |
| 21 |
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Gerig, Guido | Network inefficiencies in autism spectrum disorder at 24 months | Autism spectrum disorder (ASD) is a developmental disorder defined by behavioral symptoms that emerge during the first years of life. Associated with these symptoms are differences in the structure of a wide array of brain regions, and in the connectivity between these regions. However, the use of c... | | 2014-01-01 |
| 22 |
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Gerig, Guido | Neuroimaging of structural pathology and connectomics in traumatic brain injury: toward personalized outcome prediction | Recent contributions to the body of knowledge on traumatic brain injury (TBI) favor the view that multimodal neuroimaging using structural and functionalmagnetic resonance imaging (MRI and fMRI, respectively) as well as diffusion tensor imaging (DTI) has excellent potential to identify novel biomark... | Trauma; Neuroimaging; MRI/fMRI; Diffusion tensor; Outcome measures | 2012-01-01 |
| 23 |
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Gerig, Guido | Object models in multiscale intrinsic coordinates via m-reps | Object descriptions used for 3D segmentation by deformable models and for statistical characterization of 3D object classes benefit from having intrinsic correspondences over deformation of the objects or multiple instances in the same object class. These correspondences apply over a variety of spat... | | 2003-01-01 |
| 24 |
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Hawkes, Kristen | Ovarian follicle loss in humans and mice: lessons from statistical model comparison | Menopause is triggered by the number of ovarian follicles falling below a threshold number and is irreversible because oogonial stem cells disappear after birth. Since it is the result of programmed disappearance of a limited store of follicles, menopause can be predicted using mathematical models b... | Age; Follice; Mathematical; Model; Menopause; Ovary | 2010-01-01 |
| 25 |
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Gerig, Guido | Particle based shape regression of open surfaces with applications to developmental neuroimaging | Shape regression promises to be an important tool to study the relationship between anatomy and underlying clinical or biological parameters, such as age. In this paper we propose a new method to building shape models that incorporates regression analysis in the process of optimizing correspondences... | | 2009-01-01 |
