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1 Olivera, Baldomero M.Uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptorWe have purified and characterized a novel conotoxin from the venom of Conus obscurus, which has the unique property of selectively and potently inhibiting the fetal form of the mammalian neuromuscular nicotinic acetylcholine receptor (nAChR) (α1β1γδ-subunits). Although this conotoxin, αA-cono...Conotoxins; Conus obscurus; Fetal; Muscle; nAChR; Inhibitor; Receptor2005-01-19
2 Olivera, Baldomero M.; ; McIntosh, J. Michaelα-Conotoxin AuIB selective blocks α3ß4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine releaseNeuronal nicotinic acetylcholine receptors (nAChRs) with putative α3ß4-subunits have been implicated in the mediation of signaling in various systems, including ganglionic transmission peripherally and nicotine-evoked neurotransmitter release centrally. However, progress in the characterization of...Conotoxins; a-Conotoxin AuIB; Norepinephrine release1998
3 Olivera, Baldomero M.; McIntosh, J. Michaelα-Conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomesActivation of presynaptic nicotinic acetylcholine receptors (nAChRs) can induce the release of neurotransmitters such as dopamine and norepinephrine in the CNS. Accumulating evidence suggests that distinct nAChR subtypes are involved; however, it has been difficult to determine the subunit composit...Conotoxins; a-Conotoxin MII1997
4 Olivera, Baldomero M.; Gray, William Robert; Hillyard, David R.μ-Conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypesWe report the characterization of a new sodium channel blocker, m-conotoxin PIIIA (m-PIIIA). The peptide has been synthesized chemically and its disulfide bridging pattern determined.Conotoxins; m-Conotoxin PIIIA; Sodium channel blockers1998
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