Creator | Title | Description | Subject | Date | ||
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1 |
![]() | Lawton, Kristy J. | Motor neurons tune premotor activity in a vertebrate central pattern generator | Central patterns generators (CPGs) are neural circuits that drive rhythmic motor output without sensory feedback. Vertebrate CPGs are generally believed to operate in a top-down manner in which premotor interneurons activate motor neurons that in turn drive muscles. In contrast, the frog (Xenopus la... | CPG; feed back; synchrony; vocal; vocalization; Xenopus | 2017 |
2 |
![]() | Olivera, Baldomero M. | Uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor | We have purified and characterized a novel conotoxin from the venom of Conus obscurus, which has the unique property of selectively and potently inhibiting the fetal form of the mammalian neuromuscular nicotinic acetylcholine receptor (nAChR) (α1β1γδ-subunits). Although this conotoxin, αA-cono... | Conotoxins; Conus obscurus; Fetal; Muscle; nAChR; Inhibitor; Receptor | 2005-01-19 |
3 |
![]() | Olivera, Baldomero M.; ; McIntosh, J. Michael | α-Conotoxin AuIB selective blocks α3ß4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release | Neuronal nicotinic acetylcholine receptors (nAChRs) with putative α3ß4-subunits have been implicated in the mediation of signaling in various systems, including ganglionic transmission peripherally and nicotine-evoked neurotransmitter release centrally. However, progress in the characterization of... | Conotoxins; a-Conotoxin AuIB; Norepinephrine release | 1998 |
4 |
![]() | Olivera, Baldomero M.; McIntosh, J. Michael | α-Conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes | Activation of presynaptic nicotinic acetylcholine receptors (nAChRs) can induce the release of neurotransmitters such as dopamine and norepinephrine in the CNS. Accumulating evidence suggests that distinct nAChR subtypes are involved; however, it has been difficult to determine the subunit composit... | Conotoxins; a-Conotoxin MII | 1997 |
5 |
![]() | Olivera, Baldomero M.; Gray, William Robert; Hillyard, David R. | μ-Conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypes | We report the characterization of a new sodium channel blocker, m-conotoxin PIIIA (m-PIIIA). The peptide has been synthesized chemically and its disulfide bridging pattern determined. | Conotoxins; m-Conotoxin PIIIA; Sodium channel blockers | 1998 |