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51 Five Common Ocular Motor Signs in Cerebellar Disorders - Saccadic Hypermetria, Saccadic Pursuit & VOR Suppression, Gaze-evoked & Rebound Nystagmus(1) Saccadic hypermetria - an overshoot of the visual target (2) Saccadic smooth pursuit - due to impaired pursuit and low gain, saccades are needed to keep up with the visual target. This gives it a ‘choppy' appearance. (3) Saccadic vestibulo-ocular reflex (VOR) suppression - another...Abnormal Saccades; Abnormal Pursuit; Abnormal Vestibulo-ocular Reflex (VOR) Suppression; Jerk Nystagmus; Gaze-evoked Nystagmus; Rebound Nystagmus; Cerebellar Oms
52 Gaze-Evoked and Centripetal Nystagmus in Creutzfeldt-Jakob DiseaseThis is a 65-year-old woman who experienced a progressive cerebellopathy over several months. Initially, she presented with mild gait imbalance and positional vertigo, and there was only apogeotropic positional nystagmus (more pronounced in supine roll test compared to Dix-Hallpike) with a very slig...Jerk Nystagmus; Gaze-Evoked Nystagmus; Rebound Nystagmus
53 Gaze-evoked and Rebound Nystagmus in a Cerebellar Syndrome𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: 30-yo-man with the subacute onset of a cerebellar syndrome. After extensive evaluation and progression, it was thought that this represented an autoimmune process and there was some improvement with immunosuppression. He ...Jerk Nystagmus; End-gaze Nystagmus; Gaze-evoked Nystagmus; Rebound Nystagmus; Cerebellar Pathology
54 Gaze-Evoked Nystagmus & Slow Saccades Due to Anti-GAD Antibodies in a Patient with Stiff Person SyndromeThis is a 70-year-old woman with a several year long history of imbalance and stiffness. Exam demonstrated axial and lower extremity stiffness, and ocular motor exam demonstrated gaze-evoked nystagmus (e.g., right-beating in right gaze, left-beating in left gaze, up-beating in up gaze), and mild to ...Jerk Nystagmus; Gaze-Evoked Nystagmus; Abnormal Saccades
55 Head Movement Independent ('Sitting') Oscillopsia - A Common Symptom of Nystagmus and Saccadic Intrusions/Oscillations𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This video is an example of what a patient with spontaneous nystagmus or saccadic intrusions/oscillations experiences visually during the abnormal eye movements - i.e., oscillopsia (illusion of movement of the stationary ...
56 Head-Shaking-Induced Nystagmus Following Ramsay Hunt Vestibulopathy𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This is a 50-year-old man who experienced the abrupt onset of imbalance, dizziness and left-sided hearing loss 4 months prior to this examination. He was found to have herpetic vesicles in the left external auditory canal...Vestibular Nystagmus; Head-Shaking; Jerk Nystagmus; Vestibularcochlear; Acute Vestibular Syndrome
57 Hemifacial SpasmThis is a 45-year-old man with intermittent left facial twitching and eyelid closure for the last 6 months. With observation, spontaneous left facial spasms were seen involving the orbicularis oculi and oris muscles. With voluntary contraction of left facial muscles, with smiling for instance, there...Facial Nerve
58 Horizontal Gaze Palsy, Facial Nerve Palsy, and Nystagmus Due to Dorsal Pontine Ischemia𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: Presented here are two patients with horizontal gaze and facial palsies due to stroke. The first patient is a 60-year-old man who presented with double vision and hemiparesis due to a right dorsal pontine ischemic stroke....One-and-a-Half Syndome; Horizontal Gaze Palsy; Pons; Jerk Nystagmus; Upbeat Nystagmus; Gaze Evoked Nystagmus; Facial Nerve Palsy; Internuclear Ophthalmoplegia
59 Horner's Syndrome with Anhidrosis𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This is a patient with the onset of ptosis OD years prior, with clear evidence of a Horner's syndrome. Imaging of the oculosympathetic tract was unrevealing. The patient also mentioned that with exercise, the left side of...Horner's Syndrome
60 Hyperventilation-Induced Downbeat Nystagmus in a Cerebellar Disorder𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This is a 45-year-old woman with a chronic progressive cerebellopathy of unclear etiology (worsening over at least 10 years) characterized by gait and limb ataxia, gaze-evoked nystagmus, saccadic pursuit and vestibulo-ocu...Hyperventilation; Jerk Nystagmus; Downbeat Nystagmus; Downbeat Nystagmus; Cerebellar Pathology
61 Idiopathic Downbeat Nystagmus Exacerbated with Positional Maneuvers𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This is a 45-yo-woman with vertical oscillopsia for 6+ months, found to have downbeat nystagmus on examination. She mainly complained of dizziness and oscillopsia when laying down. She was found to have a significant exac...Downbeat Nystagmus; Jerk Nystagmus; Central Positional Nystagmus
62 Idiopathic Downbeat Nystagmus Exacerbated with Positional Maneuvers - Part 2: Patient is Now on 4-AminopyridineThis is a 45-yo-woman presented in "Idiopathic downbeat nystagmus exacerbated with positional maneuvers". This video was taken after the patient had been on 4-aminopyridine for 3 months. There was marked improvement in subjective oscillopsia and objective downbeat nystagmus. The strong positional co...Downbeat Nystagmus; Jerk Nystagmus; Central Positional Nystagmus
63 Idiopathic Downbeat Nystagmus, Decreasing with ConvergenceThis is a 25-yo-woman who experienced vertically oscillopsia for 1 year, and was found to have downbeat nystagmus. Interestingly, there were no other cerebellar ocular motor signs - e.g., normal saccades, smooth pursuit, VOR suppression, and no gaze-evoked nystagmus, although her (pure) downbeat was...Convergence-abnormal; Cerebellar Pathology; Downbeat Nystagmus; Jerk Nystagmus
64 Impaired Smooth Pursuit and Other Characteristic Ocular Motor Findings in Middle Cerebellar Peduncle Stroke𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This is a 50-year-old woman who underwent resection of a left-sided acoustic neuroma, and post-operatively, she had vertigo, binocular diplopia, left hemi-ataxia and severe gait ataxia. MR diffusion weighted imaging demon...Abnormal Pursuit; VOR-HIT Abnormal; Abnormal Alignment; Vestibulocochlear Nerve; OMS Pons; Jerk Nystagmus; Gaze-Evoked Nystagmus; Bruns Nystagmus; Vestibular Nystagmus; Acute Vestibular Syndrome
65 Inferior Oblique Overaction in a Congenital 4th Nerve Palsy60-yo-man complaining of intermittent oblique diplopia. There was a left hypertropia that worsened in down gaze, right gaze and in left head tilt. There was a large vertical fusional amplitude in addition to a longstanding rightward head tilt, and on examination there was left inferior oblique overa...Fourth (Trochlear) Nerve Palsy
66 The Influence of Convergence on Downbeat NystagmusThis is a patient presenting with progressive imbalance and oscillopsia over the course of approximately 1 year. On examination, he had cerebellar ataxia in addition to spontaneous downbeat nystagmus (DBN). His downbeat nystagmus increased in lateral and downgaze, which are characteristic features,...
67 INOs in Stroke𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This video shows 3 patients with vascular risk factors who suffered strokes of the MLF resulting in unilateral INO in each case. In the second case, INO was diagnosed status post cardiac catherization and MRI was found to...Internuclear Ophthalmoplegia; Abnormal Saccades; Gaze Evoked Nystagmus; Abducting Nystagmus
68 Internuclear Ophthalmoplegia (INO) in Multiple Sclerosis𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This video includes 3 patients each with a known history of MS found to have unilateral or bilateral INOs on their exam. In the first 2 patients, the INOs are relatively subtle with normal adduction. However, with rapid h...Internuclear Ophthalmoplegia; Abnormal Saccades; Gaze Evoked Nystagmus
69 Ipsitorsional Quick Phases with Head Tilt in a Normal SubjectThis is a demonstration of ocular counterroll, which can be seen when the head is tilted to the right or to the left. For example, when the head is tilted to the right, the top poles of both eyes should rotate toward the left ear to keep the top poles oriented with earth vertical. This is part of ...
70 Jerk Nystagmus𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This is an example of jerk nystagmus due to a central vestibular lesion. The slow phase is the pathologic phase (to the left) which initiates the movement, and is followed by a fast position reset mechanism (to the right)...
71 Latent Nystagmus and DVD in Infantile EsotropiaThis is a 20-year-old woman with infantile esotropia (s/p strabismus surgery as a child) who demonstrated latent nystagmus and presumed dissociated vertical deviation (DVD) OS, which are commonly seen with infantile esotropia (also inferior oblique overaction and monocular nasotemporal asymmetry to ...Alignment Abnormal; Jerk Nystagmus; Latent Nystagmus
72 Leukemic Leptomeningeal Carcinomatosis Causing 4th and 6th Nerve Palsies𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This is a 55-yo-man with CML that recurred as AML. Diagonal diplopia developed, and on examination he was found to have a partial right 6th nerve palsy, in addition to a left hypertropia that increased in right gaze, down...Abnormal Range; Fourth Nerve Palsy; Sixth Nerve Palsy
73 Light Near Dissociation in a Tonic Pupil𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This is a 65-year-old woman who noticed difficulty reading and heightened sensitivity to lights OS for the last 6 months. On examination, there was mydriasis OS of about 6 mm (3 mm OD). The left (mydriatic) pupil constric...Tonic Pupil
74 Medial Longitudinal Fasciculus Syndrome with Prominent Spontaneous Nystagmus𝗢𝗿𝗶𝗴𝗶𝗻𝗮𝗹 𝗗𝗲𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻: This is a 60-year-old man who experienced the abrupt onset of diplopia and imbalance. He had typical features of a left medial longitudinal fasciculus (MLF) syndrome including left internuclear ophthalmoplegia (INO) and l...INO; Jerk Nystagmus; Upbeat Nystagmus; Rotary Nystagmus; Skew Deviation; OMS Pons; Abnormal Alignment; Abducting Nystagmus
75 Medial Medullary SyndromesThis is a video of two patients who suffered small strokes involving the right medial medulla, and who presented with acute vertigo and oscillopsia. The first patient in the video had pure upbeat nystagmus, while the second patient had upbeat-torsional (towards the right ear) nystagmus in addition t...Medulla; Jerk Nystagmus; Upbeat Nystagmus; Gaze Evoked Nystagmus; Vestibular Nystagmus; Acute Vestibular
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