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1 Olivera, Baldomero M.Poly(ADP-ribosylation) of a DNA topoisomeraseA DNA topoisomerase activity, copurifying with poly(ADP-ribose) synthetase from calf thymus, >95% inhibited if extensive poly(ADP-ribosylation) is allowed to occur. The inhibited DNA topoisomerase, which has drastically different elution properties on hydroxylapatite, can be reactivated by mild alka...Nicotinic acid; ADP-ribosylation; Turnover cycle; Synthetases1983
2 Olivera, Baldomero M.; Hillyard, David R.Pyridine nucleotide cycle: studies in Escherichia coli and the human cell line D98/AH2Different metabolic steps comprise the pyridine nucleotide cycles in Escherichia coli and in the human cell line HeLa D98/AH2. An analysis of the "P-labeling patterns in vivo reveals that in E. coli, pyrophosphate bond cleavage of intracellular NAD predominates, while in the human cell line, cleava...Nicotinic acid; Turnover cycle; DNA ligation; Nicotinamide1981
3 Olivera, Baldomero M.Pyridine nucleotide metabolism in Escherichia coli. IV. TurnoverThere are two pyridine nucleotide turnover pathways in Escherichia coli, the Gholson turnover cycle, with nicotinamide as an intermediate, and a second new pathway which does not involve nicotinamide. In exponentially growing cultures with a generation time of 60 min, the rates of these cycles are ...Turnover cycle; Adenine1973
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