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1 Beckerle, Mary C.LIM domain-containing protein Trip6 can act as a coactivator for the v-Rel transcription factorThe retroviral oncoprotein v-Rel is a transcriptional activator in the Rel/NF-KB family of eukaryotic transcription factors. v-Rel malignantly transforms a variety of cell types in vitro and in vivo, and its transforming activity is dependent on the ability of v-Rel to bind to DNA and activate trans...LIM domains; Oncoproteins; v-Rel; Retroviral oncogene; Trip6; Coactivator; Malignant transformation; NF-kB; Two-hybrid assay1999
2 Beckerle, Mary C.Members of the zyxin family of LIM proteins interact with members of the p130cas family of signal transducersIntegrin binding to extracellular matrix proteins induces formation of signaling complexes at focal adhesions. Zyxin co-localizes with integrins at sites of cellsubstratum adhesion and is postulated to serve as a docking site for the assembly of multimeric protein complexes involved in regulating ce...Zyxin; Actin; LIM domains; Trip6; Focal adhesions2002
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