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| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
 | Couldwell, William T. | Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen | PREVIOUS WORK HAS demonstrated the importance of the Protein Kinase C (PKC) signal transduction system in regulating the growth rate of malignant gliomas in vitro. Tamoxifen inhibits PKC in a minority of malignant gliomas within the micromolar concentration range in vitro, a property distinct from... | Tamoxifen; Protein kinase C; Glioma; Brain neoplasm; Chemotherapy; Glioma | 1993 |
| 2 |
 | Couldwell, William T. | Paradoxical elevation of Ki-67 labeling with protein kinase inhibition in malignant gliomas | The monoclonal antibody Ki-67 recognizes a nuclear antigen expressed in the G1, S, G2, and M phase of the cell cycle and has been used extensively as an indicator of cellular proliferation in malignant gliomas, both in the laboratory and clinically. Recently, protein kinase C (PKC) inhibitors have b... | Brain neoplasm; Chemotherapy; Glioma; Monoclonal antibody; Ki-67; Protein kinase C; Tamoxifen | 1995 |
| 3 |
 | Couldwell, William T. | Protein kinase C and growth regulation in malignant gliomas | To the Editor: The presence of amplified growth factor systems in many tumor models, including malignant gliomas, raises the question of how such external signals are transduced into a transformed phenotype (increased proliferation, invasion, lack of contact inhibition, angiogenic capacity, etc.). ... | Protein kinase C; Glioma; Brain neoplasm; protooncogenes; Apoptosis; Tamoxifen | 1994 |
| 4 |
 | Couldwell, William T. | Protein kinase C inhibitors suppress cell growth in established and low-passage glioma cell lines. a comparison between staurosporine and tamoxifen | WE HAVE PREVIOUSLY demonstrated that the proliferation of established human glioma cell lines correlated with protein kinase C (PKC) activity and that a relatively selective PKC inhibitor, staurosporine, inhibits glioma cell proliferation. The purpose of this study was to determine whether low-passa... | Staurosporin; Tamoxifen; Protein kinase C; Glioma; Brain neoplasm; Glioma cell lines | 1993 |
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