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1 Olivera, Baldomero M.Poly(ADP-ribosylation) of a DNA topoisomeraseA DNA topoisomerase activity, copurifying with poly(ADP-ribose) synthetase from calf thymus, >95% inhibited if extensive poly(ADP-ribosylation) is allowed to occur. The inhibited DNA topoisomerase, which has drastically different elution properties on hydroxylapatite, can be reactivated by mild alka...Nicotinic acid; ADP-ribosylation; Turnover cycle; Synthetases1983
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