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Filters: Format: "application/pdf" Collection: "ir_uspace" Subject: "Supervillin"
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1 Beckerle, Mary C.; Hoffman, Laura M.Supervillin modulation of focal adhesions involving TRIP6/ZRP-1Cell-substrate contacts, called focal adhesions (FAs), are dynamic in rapidly moving cells. We show that supervillin (SV)-a peripheral membrane protein that binds myosin II and F-actin in such cells-negatively regulates stress fibers, FAs, and cell-substrate adhesion. The major FA regulatory sequenc...Supervillin; Focal adhesions; Zyxin; LIM domains; TRIP62006
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