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| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
 | Couldwell, William T. | Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro | Direct measurement of protein kinase C (PKC) activity in vitro revealed a significant increase in the activity of the enzyme in all human malignant glioma lines examined and the rat C6 tumor in comparison with control nonneoplastic astrocyte and mixed glial cultures. The total and particulate PKC ac... | Brain neoplasms; Flow cytometry; Glioma; Phorbol ester; Protein kinase C | 1991 |
| 2 |
 | Couldwell, William T. | Inhibition of growth of established human glioma cell lines by modulators of the protein kinase-C system | The protein kinase-C (PKC) second messenger system contributes to regulation of cell growth and differentiation. This study was undertaken to examine the effects of modulators of the PKC enzyme system on the state of differentiation and proliferation rates of human gliomas in vitro. The administrat... | Protein kinase C; Phorbol ester; Cell proliferation; Tumor cell growth; Astrocyte; Glioma; Immunohistochemistry | 1990 |
| 3 |
 | Couldwell, William T. | Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of protein kinase C | THE PROLIFERATION RATES of gliomas may be modulated by the protein kinase C (PKC) signal transduction system. The present study was undertaken to further examine the role of PKC system in growth regulation of gliomas in vitro by measurement of PKC activity over various phases of tumor growth and by ... | Protein kinase C; Brain neoplasms; Growth factor; Glioma; Phorbol ester | 1992 |
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