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| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
 | Capecchi, Mario R. | How close are we to implementing gene targeting in animals other than the mouse? | Describes several significant contributions that bring us much closer to extending ‘‘gene targeting'' to mammalian species other than the mouse. Gene targeting now provides the means for creating new strains of mice with mutations in virtually any gene. First, the desired mutation is introduced ... | Cattle; Mutagenesis; Mice; Humans; Ethics, Medical | 2000-02-01 |
| 2 |
 | Singleton, J. Robinson; Smith, A. Gordon | Microvascular complications of impaired glucose tolerance. | Impaired glucose tolerance (IGT) serves as a marker for the state of insulin resistance and predicts both large- and small-vessel vascular complications, independent of a patient's progression to diabetes. Patients with IGT are at significantly increased risk for death and morbidity due to myocardia... | Microcirculation; Humans | 2003-12-01 |
| 3 |
 | Kriesel, John D.; Spruance, Spotswood L. | Rocky Mountain spotted fever following cardiac transplantation. | ROCKY MOUNTAIN SPOTTED FEVER was first recognized in the early 1 900s in the Snake River Valley of Idaho and the Bitterroot Valley of western Montana.t In 1909, Howard Taylor Ricketts established the ixodid tick as the vector for the disease.2 Following the tick bite, the incubation period aver... | Male; Adult; Humans | 1993 |
| 4 |
 | Capecchi, Mario R. | Xanthine oxidoreductase is central to the evolution and function of the innate immune system. | The housekeeping enzyme xanthine oxidoreductase (XOR) has been studied intensively over the past 100 years, yet the complexity of its in vivo function is still poorly understood. A large body of literature focuses on the different catalyltic forms of XOR and their importance in the synthesis of reac... | Animals; Gene Expression Regulation, Enzymologic; Humans; Immune System; Models, Biological | 2003-09-01 |
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