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| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
 | Capecchi, Mario R. | Gene targeting: tapping the cellular telephone. | Gene targeting means that we now have the potential to generate mice of virtually any desired genotype. In the first instance, standards recombinant DNA technology is used to alter a cloned DNA sequence of a chosen locus; the modified potent stem cell derived from a mouse embryo, and homologous reco... | Animals; Blotting, Southern; Bone and Bones; Gene Targeting; Genotype; Immunochemistry; In Situ Hybridization; Mice | 1990-03-08 |
| 2 |
 | Liew, Michael; Erali, Maria; Page, Sam; Hillyard, David R.; Wittwer, Carl T. | Hepatitis C genotyping by denaturing high-performance liquid chromatography | Determination of the hepatitis C virus (HCV) genotype for infected patients increasingly has become accepted as the standard of care. Genotype assignment helps in assessing disease prognosis and assists in establishing the appropriate duration of treatment. The great genetic diversity of HCV, with 1... | Base Sequence; 5' Untranslated Regions; Genotype; Hepacivirus; Molecular Sequence Data | 2004-01 |
| 3 |
 | Capecchi, Mario R. | Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. | The thymus, thyroid, and parathyroid glands in vertebrates develop from the pharyngeal region, with contributions both from pharyngeal endoderm and from neural crest cells in the pharyngeal arches. Hoxa3 mutant homozygotes have defects in the development of all three organs. Roles for the Hoxa3 para... | Animals, Newborn; Calcitonin; Ectoderm; Gene Dosage; Genotype; Mice, Mutant Strains; Phenotype | 1998-03-01 |
| 4 |
 | Capecchi, Mario R. | Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. | Although the role of Hox genes in patterning the mammalian body plan has been studied extensively during embryonic and fetal development, relatively little is known concerning Hox gene function in adult animals. Analysis of mice with mutant Hoxa9, Hoxb9, and Hoxd9 genes shows that these paralogous g... | Embryonic and Fetal Development; Gene Expression Regulation, Developmental; Genotype; Mice, Knockout | 1999-01 |
| 5 |
 | Thomas, Kirk R.; Capecchi, Mario R. | Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. | The int-1 proto-oncogene was first identified as a gene activated in virally induced mouse mammary tumours. Expression studies, however, suggest that the normal function of this gene may be in spermatogenesis and in the development of the central nervous system. Genes sharing sequence similarity wit... | Animals; Blastocyst; Cell Line; Chimera; DNA; Female; Genotype; Heterozygote; Homozygote; Male; Mice, Inbred C57BL; Motor Activity | 1990-08-30 |
| 6 |
 | Jorgensen, Erik | Wormwholes: a commentary on K. F. Schaffner's "Genes, behavior, and developmental emergentism | Although Caenorhabditis elegans was chosen and modified to be an organism that would facilitate a reductionist program for neurogenetics, recent research has provided evidence for properties that are emergent from the neurons. While neurogenetic advances have been made using C elegans which may be u... | Organism; Neurons; Genotype | 1998 |
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