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| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
 | Moon, Ann M.; Capecchi, Mario R. | Fgf8 is required for outgrowth and patterning of the limbs. | The expression pattern and activity of fibroblast growth factor-8 (FGF8) in experimental assays indicate that it has important roles in limb development, but early embryonic lethality resulting from mutation of Fgf8 in the germ line of mice has prevented direct assessment of these roles. Here we rep... | Animals; Body Patterning; Bone Morphogenetic Proteins; Ectoderm | 2000-12-26 |
| 2 |
 | Capecchi, Mario R. | Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. | The thymus, thyroid, and parathyroid glands in vertebrates develop from the pharyngeal region, with contributions both from pharyngeal endoderm and from neural crest cells in the pharyngeal arches. Hoxa3 mutant homozygotes have defects in the development of all three organs. Roles for the Hoxa3 para... | Animals, Newborn; Calcitonin; Ectoderm; Gene Dosage; Genotype; Mice, Mutant Strains; Phenotype | 1998-03-01 |
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