Creator | Title | Description | Subject | Date | ||
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![]() | Capecchi, Mario R. | Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death | To investigate the local effects of angiotensin II on the heart, we created a mouse model with 100-fold normal cardiac angiotensin-converting enzyme (ACE), but no ACE expression in kidney or vascular endothelium. This was achieved by placing the endogenous ACE gene under the control of the α-myo... | Atrial enlargement; Cardiac arrhythmia; ACE | 2004 |