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1 Couldwell, William T.Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitroDirect measurement of protein kinase C (PKC) activity in vitro revealed a significant increase in the activity of the enzyme in all human malignant glioma lines examined and the rat C6 tumor in comparison with control nonneoplastic astrocyte and mixed glial cultures. The total and particulate PKC ac...Brain neoplasms; Flow cytometry; Glioma; Phorbol ester; Protein kinase C1991
2 Couldwell, William T.Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of protein kinase CTHE PROLIFERATION RATES of gliomas may be modulated by the protein kinase C (PKC) signal transduction system. The present study was undertaken to further examine the role of PKC system in growth regulation of gliomas in vitro by measurement of PKC activity over various phases of tumor growth and by ...Protein kinase C; Brain neoplasms; Growth factor; Glioma; Phorbol ester1992
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