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Filters: Format: "application/pdf" Collection: "ir_uspace" Subject: "Brain neoplasm"
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1 Couldwell, William T.Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifenPREVIOUS WORK HAS demonstrated the importance of the Protein Kinase C (PKC) signal transduction system in regulating the growth rate of malignant gliomas in vitro. Tamoxifen inhibits PKC in a minority of malignant gliomas within the micromolar concentration range in vitro, a property distinct from...Tamoxifen; Protein kinase C; Glioma; Brain neoplasm; Chemotherapy; Glioma1993
2 Couldwell, William T.Hypericin: a potential antiglioma therapyHYPERICIN, A POLYCYCLIC aromatic dione isolated from plants, is presently being clinically evaluated as an antiviral agent in the treatment of human immunodeficiency virus (HIV) infection. In addition, it is known to be a potent protein kinase C inhibitor. To evaluate its potential as an inhibitor o...Hypericin; Protein kinase C; Glioma; Brain neoplasm1994
3 Couldwell, William T.Paradoxical elevation of Ki-67 labeling with protein kinase inhibition in malignant gliomasThe monoclonal antibody Ki-67 recognizes a nuclear antigen expressed in the G1, S, G2, and M phase of the cell cycle and has been used extensively as an indicator of cellular proliferation in malignant gliomas, both in the laboratory and clinically. Recently, protein kinase C (PKC) inhibitors have b...Brain neoplasm; Chemotherapy; Glioma; Monoclonal antibody; Ki-67; Protein kinase C; Tamoxifen1995
4 Couldwell, William T.Petroclival meningiomas: surgical experience in 109 casesThe surgical removal of petroclival meningiomas has historically been associated with a high incidence of morbidity and mortality. The 109 consecutive patients included in the present retrospective study represent a combined series of tumors operated on by the four authors during a period from 1980 ...Petroclival meningiomas; Clivus; Brain neoplasm; Petrous bone; Posterior fossa; Skull base tumor1996
5 Couldwell, William T.Protein kinase C and growth regulation in malignant gliomasTo the Editor: The presence of amplified growth factor systems in many tumor models, including malignant gliomas, raises the question of how such external signals are transduced into a transformed phenotype (increased proliferation, invasion, lack of contact inhibition, angiogenic capacity, etc.). ...Protein kinase C; Glioma; Brain neoplasm; protooncogenes; Apoptosis; Tamoxifen1994
6 Couldwell, William T.Protein kinase C inhibitors suppress cell growth in established and low-passage glioma cell lines. a comparison between staurosporine and tamoxifenWE HAVE PREVIOUSLY demonstrated that the proliferation of established human glioma cell lines correlated with protein kinase C (PKC) activity and that a relatively selective PKC inhibitor, staurosporine, inhibits glioma cell proliferation. The purpose of this study was to determine whether low-passa...Staurosporin; Tamoxifen; Protein kinase C; Glioma; Brain neoplasm; Glioma cell lines1993
7 Schmidt, Meic H.Role of photodynamic therapy in posterior fossa brain tumors: a preclinical study in a canine glioma modelPhotodynamic therapy was studied in dogs with and without posterior fossa glioblastomas. This mode of therapy consisted of intravenous administration of Photofrin-II at doses ranging from 0.75 to 4 mg/kg 24 hours prior to laser light irradiation in the posterior fossa. Tissue levels of Photofrin-l...Brain neoplasm; Posterior fossa; Photodynamic therapy; Glioblastomas; Dog; Photofrin-II; Canine glioma model1993
8 Kestle, John R. W.Value of postoperative surveillance imaging in the management of children with some common brain tumorsThe rationale for obtaining surveillance computerized tomography (CT) scans or magnetic resonance (MR) images in pediatric patients with brain tumors is that early detection of recurrence may result in timely treatment and better outcome. The purpose of this study was to investigate the value of sur...Brain neoplasm; Brain tumors; Computerized tomography scanning; Surveillance; Postoperative surveillance1996
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