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| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
 | Olivera, Baldomero M. | Poly (ADP-ribosylation) in Vitro: reaction parameters and enzyme mechanism | The reaction catalyzed by poly(ADP-ribose) synthetase from bovine thymus was investigated using the purified enzyme, calf thymus DNA, and histone H1. The rate and extent of poly(ADP-ribosylation), as well as the spectrum of acceptor proteins, changed as reaction conditions were varied. The ionic co... | ADP-ribosylation; Poly(ADP-ribose) synthetase; Histone H1 | 1982 |
| 2 |
 | Olivera, Baldomero M. | Poly(ADP-ribosylation) of a DNA topoisomerase | A DNA topoisomerase activity, copurifying with poly(ADP-ribose) synthetase from calf thymus, >95% inhibited if extensive poly(ADP-ribosylation) is allowed to occur. The inhibited DNA topoisomerase, which has drastically different elution properties on hydroxylapatite, can be reactivated by mild alka... | Nicotinic acid; ADP-ribosylation; Turnover cycle; Synthetases | 1983 |
| 3 |
 | Olivera, Baldomero M. | Poly(ADP-ribosylation) of DNA topoisomerase I from calf thymus | We demonstrate that the activity of the major DNA topoisomerase I from calf thymus is severely inhibited after modification by purified poly(ADP-ribose) synthetase. Polymeric chains of poly(ADP-ribose) are covalently attached to DNA topoisomerase I. These observations with highly purified enzymes ... | ADP-ribosylation; Poly(ADP-ribose) synthetase | 1984 |
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