Honors Theses Open Access
 
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1 Curtis, Kaili BreannThe Effect of Inflammatory Components on Influenza a Virulence EvolutionThe methodology for passaging influenza A virus in the mouse model has widely been established. However, traditional infection methods involving the inoculation of lung homogenates fail to account for the possible effects of host-associated factors on measures of virulence and in the virulence evolu...2020
2 Acosta, LehiGenotype-dependent susceptibility to influenza and titer-virulence discordanceThe influenza a virus (IAV) is a major source of human mortality and both recent and anticipated pandemics make understanding this major human pathogen of paramount importance1,2. The use of mouse models allows us to experimentally manipulate critical variables to more fully understand the dynamics ...Influenza A virus - Research; Mice as laboratory animals - Research; Transmissibility; Virulence; Viral titers; Erythropoeintin2016-05
3 Hyer, Christina CottrellEffect of M1 Matrix Protein on Hemagglutinin Expression and Influenza Virus-Like Particle Production in Trichoplusia NIVirus-like particles (VLPs) are a new and effective flu vaccine approach. VLPs are non-infectious and can produce robust immune responses. Flu VLPs are typically created by co-expressing the flu hemagglutinin (HA) surface antigen and the matrix protein M1-which assists in viral and VLP budding-in cu...2017
4 Farese, LudovicaThe impact of Global Health education in American Academic Medical Center (AAMCS)Global health has become an increasingly popular field of study among college and graduate students in the United States. A growing body of literature purports the benefits of Global Health Education (GHEs) in American Academic Medical Centers (AAMCs), including introduction to a wider spectrum of d...2018
5 Goel, DivyamEvidence-based medicine in times of crises: what we can learn from covid-19 to adapt early on in a pandemicEvidence-based medicine (EBM) is the current philosophical paradigm by which contemporary healthcare practices are guided. A related field, evidence-based public health (EBPH), similarly advises practices in the field of public health. However, the COVID-19 pandemic has demonstrated weaknesses in th...2022
6 Pannier, Samantha T.African Americans, women, and the 1910 Flexner report: progressive medical reform and professional exclusionBetween the Civil War and the turn of the twentieth century the American medical profession expanded greatly both in size and in attention paid to scientific knowledge. During this time African Americans, women, and even African American women gained access to medical education through the prolifera...Medicine - Study and teaching - United States; Women in medicine - United States; African Americans in medicine - United States2016-04
7 Watkins, Ryan DavisSuppression of lymphangiogenesis using VEGF-C trapThe lymphatic system is responsible for controlling systemic fluid buildup. Lymphangiogenesis is a dynamic process involving sprouting, and maintaining new lymphatic vasculature. Vascular endothelial growth factor C (VEGF-C) is as a key growth factor that induces lymphangiogenesis by binding VEGF re...Lymphatics - Growth; Vascular endothelial growth factors - Antagonists; Lymphangiogenesis; VEGF-C trap2014-05
8 Kearns, Ireland RoseEffects of trem-1 expression on acute phase seizures in a mouse model of viral-induced epilepsyAround 70 million people worldwide suffer from epilepsy, a neurological disorder that causes unprovoked and persistent seizures. A dominant cause of acquired epilepsies are from injuries to the central nervous system (CNS), such as viral infection of the CNS that results in brain inflammation (encep...2022
9 Ballif, MicahDrugs and Pregnancy: Clinical Management with a Cystic Fibrosis FocusDespite the large number of women who become pregnant and use a medication during their pregnancy, there is very little information about the safety of the majority of medications. Most drugs approved by the FDA have undetermined teratogenic risk, but their use is prevalent in the management of dise...2019
10 Arave, Rowan A.AKT1 activation promotes the development of melanoma metastasisMetastases are the major cause of melanoma-related mortality. Previous studies implicating aberrant AKT (or protein kinase B) signaling in human melanoma metastases led to the evaluation of the effect of activated AKT1 expression in non-metastatic BRAFV600E/cyclin dependent kinase inhibitor 2a nu...Melanoma - Genetics - Research; Metastasis - Genetics - Research; Biochemistry; Genetics2015-12
11 Mann, SaraApplying the theory of planned behavior to aggressive treatments at the end-of-lifePhysicians and other health care experts are continuously studying the efficacy of treatments and their long-term effects. For instance, research has shown that aggressive end-of-life care could be potentially more harmful to the patient than previously known. Naturally, this has led to a wave of ...Terminal care; Death2016-04
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