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1 Koblanski, KasperLiver foxn3 increases pancreatic a-cell mass without altering hepatic amino acid utilizationInsulin injection into peripheral tissues inefficiently controls elevated fasting blood glucose in type 1 diabetes mellitus (DM1) patients. Peripheral insulin lacks the signaling of healthy β-cell insulin, which directs adjacent pancreatic α-cells to stop production of glucagon, a hormone releasin...2022
2 Yang, KevinThe Soluble (PRO) Renin Receptor does not Influence Lithium-Induced Diabetes Insipidus but does Provoke Beigning of White Adipose Tissue in MiceEarlier we reported that the recombinant soluble (pro) renin receptor sPRR-His upregulates renal aquoporin-2 (AQP2) expression, and attenuates polyuria associated with nephrogenic diabetes insipidus (NDI) induced by vasopressin type 2 receptor (V2R) antagonism. Patients that receive lithium therapy ...
3 Walker, KortnieUnderstanding and treating diabetic retinopathyDiabetic retinopathy is a neurovascular disease of the retina and is the leading cause of blindness in the working-age population in the United States. Complications as a result of hyperglycemia and diabetes mellitus (DM) break down the blood-retina barrier (BRB) and retinal vasculature. Current tre...Diabetic retinopathy2015-05
4 Russo, JenniferDo reproductive-age women increase their physical activity levels during the first four weeks of the diabetes prevention program?Purpose: The purpose of this thesis was to determine if reproductive-age women enrolled in the Diabetes Prevention Program (DPP) increased their physical activity levels in the first four weeks of the lifestyle change program and to examine the relationship between physical activity levels and lifes...2021
5 Rashid, InakhshmiCommunication between young adults and family members with type 2 diabetesWith a staggering 537 million adults living with type 2 diabetes (T2D) as of 2021, T2D has become one of the most prevalent chronic conditions in the world. Lowering this prevalence is possible as T2D is preventable through healthy lifestyle habits, even amongst people with an increased risk due to ...2023
6 Reimers, NoelleExploring the role of lipied metabolism in hepatocellular carcinomaHepatocellular carcinoma (HCC) is an aggressive cancer with poor survival rates and limited treatment options whose prevalence is expected to increase up to 137% by 2030. Existing therapies outside of liver resection or transplantation have poor efficacy, and few new treatment options have been deve...2021
7 Johnson, KariAnne RencherIdentification of PASK substrates and/or interacting proteinsPAS kinase (PASK) is an evolutionary conserved serine/threonine kinase that appears to have a role in the regulation of cellular energy metabolism. It has previously been shown that mice lacking PASK (PASK"/_ mice) are resistant to the development of hepatic steatosis (lipid accumulation in the live...Biology2012-05
8 Astin, Holly M.Modulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in Zebrafish2016
9 Ruan, TingEndogenous ceramide contributes to cardiovascular complications in Type II diabetes by decreasing the association between PP2A and I2PP2ACardiovascular complications are the leading cause of death in individuals with conditions associated with insulin resistance, e.g. type 2 diabetes, diet-induced obesity. In patients with type 2 diabetes, cardiovascular complications are 2-4 times more prevalent. One common cardiovascular complicati...Ceramides - Physiological effect; Diabetic angiopathies2014
10 Thompson, LaurenSptlC2 Deletion in Endothelial Cells: Implications for Arterial FunctionUsing pharmacological and genetic approaches to inhibit whole-body ceramide biosynthesis, our laboratory showed that this sphingolipid contributes importantly to hypertension and vascular dysfunction associated with diet-induced obesity in mice. Here we tested the hypothesis that inducible, endothel...2020
11 Smith, Jaclynn KehaulaniA feasibility trial to determine the effect of mindfulness on weight-loss maintenancePURPOSE: Over 70% of all adults in the U.S. have overweight and obesity. Weight loss is often recommended to improve overall health and risk of disease. However, weight regain following intentional weight loss is common and diminishes initial improvements. Therefore, interventions aimed at attenuati...2023
12 Chong, AlishaEffects of increasing sleep duration on C-Reactive protein, insulin sensitivity, and blood pressure in adults with habitual short sleepShort sleep, cardiovascular disease, and type 2 diabetes are all highly prevalent health issues in modern society. Previous findings demonstrate that obtaining short sleep is linked to an increased risk of cardiometabolic diseases such as type 2 diabetes and heart disease. However, the mechanisms un...2023
13 Lei, Jeffrey KaChonIncreased gluti expression in mouse cardiomyocytes preserves mitochondrial function but is insufficient to attenuate pressure overload-induced contractile dysfunctionLifelong over-expression of GLUT1 transporter in the heart has been shown to preserve contractile function after aortic constriction. However it is unclear whether this protective effect is due to GLUT1 overexpression itself or due to reprogramming of heart metabolism as a result of long-term increa...Bioengineering2013-04
14 Pham, John V.The function of the protein VCP/CDC48-associated mitochondrial stress-responsive 1 in mammalsAlthough mitochondrial dysfunction has been linked to many human diseases, mitochondrial interacting proteins and protein quality controls are just beginning to be understood. The objective of our study was to characterize the function of the VMS1 protein in mammals. We determined the role of Vms1 o...Mitochondrial disorders; Mitochondrial diseases - genetics; VMS12012-05
15 Ballif, MicahDrugs and Pregnancy: Clinical Management with a Cystic Fibrosis FocusDespite the large number of women who become pregnant and use a medication during their pregnancy, there is very little information about the safety of the majority of medications. Most drugs approved by the FDA have undetermined teratogenic risk, but their use is prevalent in the management of dise...Physicians; University of Utah Hospital's; antibiotics2019
16 Astin, M. HollyModulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in ZebrafishThe liver X receptors (LXRs) are important regulators of lipid and cholesterol metabolism and control diverse pathways in development, reproduction, metabolism, immunity and inflammation. Thus, LXRs have potential as therapeutic targets for diseases as diverse as lipid disorders, atherosclerosis...Liver X receptors - Research; Zebrafish - genetics2016-08
17 Streeter, ForestDeficiency in regulator of G-Protein signaling, LOCO, protects D. Melanogaster from effects of a high Salt dietGerontology and studies of aging have been grappling with the effects of a westernized diet for decades now. Some of these effects include diseases related to overconsumption such as obesity, diabetes, hypertension, cardiovascular disease, stroke, and many more. These pathologies are now contributor...2021
18 Farese, LudovicaThe impact of Global Health education in American Academic Medical Center (AAMCS)Global health has become an increasingly popular field of study among college and graduate students in the United States. A growing body of literature purports the benefits of Global Health Education (GHEs) in American Academic Medical Centers (AAMCs), including introduction to a wider spectrum of d...2018
19 Meaux, Scott AlanBorders of immunity redefined under the scope of scaleBorders. A line in the sand as it were, a place with a definite beginning and a hazy ending. Whether respected or disregarded, an entity that most simply can't ignore. The choice to see them as helpful or to ensure harm, divisiveness washes away all connotation. Often defined in the classroom as an ...2022
20 Rose, StevenBiofuel cells for self powered arsenic detectionResearch in the Minteer group has centered on procedures for immobilizing enzymes and organelles on carbon electrodes for use in sensory and fuel cell applications. Similar strategies have been used to prepare a series of electrodes capable of pyruvate oxidation which, in the presence of arsenic, wi...Fuel cells; Arsenic - Detection2013-05
21 Kasera, ShaliniEffect of IUGR and supplemental DHA on molecular mediators of hepatic lipid accumulation in the ratIntrauterine growth restriction (IUGR) refers to failure of the fetus to achieve its genetic growth potential in utero and is commonly caused by uteroplacental insufficiency secondary to maternal hypertensive disorders. A hallmark of IUGR is a decrease in circulating docosahexaenoic acid (DHA), an �...2022
22 McFarland, CaseyHospital-Acquired pressure injury risk in medical intensive care unit patients with COVID-19: a retrospective cohort studyBackground: Hospital acquired pressure injuries (HAPrIs), defined as injuries to the skin or underlying tissue as a result of pressure or pressure in combination with shear, occur in approximately 6% MICU patients at the University of Utah hospital. HAPrIs are associated with longer length of hospit...2021
23 Stewart, CadenPaternal diet modulates naturalistic foraging in mice and interacts with cacna1c genetic effects to shape decision sequencesSome of the largest challenges facing the healthcare system stem from the dual epidemics of obesity and mental disorders. Obesity can alter an organism's epigenetics, and these changes may be passed on to offspring, which in turn may alter mental health. The purpose of this study is to investigate t...2022
24 Ramous, CarolineIs Intact Endothelial Cell Autophagy Required for Training-Induced Vascular Adaptations?Macroautophagy is operational during basal conditions to maintain intracellular organelle and protein quality control, but is upregulated during cellular stress (e.g., dynamic exercise) to adapt to changing nutritional and energy demands. We tested the hypothesis that intact endothelial cell (EC) au...2020
25 Sanders, SaraDevelopment of a novel, coumarin-europium sensor for reactive oxidizing speciesThe synthetic framework has been developed for two fluorescent probes of Reactive Oxidizing Species (RoxS) based on a coumarin-europium fluorescence pair. The coumarin moiety's selectivity for hydrogen peroxide coupled with 620 nm shifted emission of the europium will make these novel sensors biolog...Reactive Oxygen Species - analysis2012-05
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