|
|
Creator | Title | Description | Subject | Date |
1 |
|
Hinchman, Colin | 4D flow characteristics of left atrial blood flow after atrial fibrillation | Atrial fibrillation is the most prevalent cardiac arrhythmia and causes increased risk for stroke, yet accurate pathophysiological diagnosis remains a challenge. This study aimed to further investigate the physiologic biomarkers in the left atrium (LA) related to atrial fibrillation (AF) using 4D fl... | | 2019 |
2 |
|
Hanes, Josh T. | A comparison of nuclear thermal rockets with traditional chemical rockets for space transport | The Solar System has multiple destinations that private and governmental space agencies are planning to explore. Missions within the Solar System are both exorbitantly expensive and time intensive projects that involve high risks for the organizations involved. A mission that is currently being... | Nuclear rockets - research; space vehicles - design - research; nuclear thermal rockets; chemical rockets; space transport | 2016-04 |
3 |
|
Lee, Charles Chang Suk | A demonstration apparatus for optical pumping of rubidium | Optical pumping refers to the use of light in order to elevate ("pump") the spin (intrinsic angular momentum) of an atom or molecule. This process is of interest from a pedagogical and experimental perspective because it encapsulates fundamental properties of atomic physics and quantum mechanics. Fu... | Optical pumping -- Research Spin exchange -- Research Rubidium isotopes -- Research | 2015-05 |
4 |
|
German, Massiell | A genetic analysis of VSX2 function in the mouse eye | Vsx2 is a homeodomain-containing transcription factor essential for maintenance of neuroretinal identity and neurogenesis. Vsx2 is believed to function via mechanisms that are strictly cell-intrinsic. However, recent research reveals evidence for involvement of Vsx2-mediated cell non-autonomous mech... | Neurogenesis - physiology | 2012-05 |
5 |
|
Sperber, Alexander M. | A novel approach to differentiating cardiac fibroblasts from induced pluripotent stem cells | Heart disease remains the leading cause of death in the United States, and such disease is caused by electrical, chemical, or biomechanical imbalances in the heart. The two most abundant cells comprising the heart that are responsible for these functions are cardiomyocytes and cardiac fibroblasts. I... | | 2022 |
6 |
|
Godfrey, Rose | A porcine model for the development and testing of preoperative skin preparations | Clinical preoperative skin preparations (PSPs) do not eradicate skin flora dwelling in the deepest dermal regions. Survivors constitute a persistent infection risk. In search of solutions, we created a porcine model intended for PSP developmental testing. This model employed microbiological techniqu... | | 2022 |
7 |
|
Martin, Isaac | A result concerning the F-Signature and the torsion divisors of strongly F-Regular singularities | Polstra showed that the cardinality of the torsion subgroup of the divisor class group of a local strongly F-regular ring is finite. In this thesis, we first provide an expository introduction to the field of F-singularities before improving upon Polstra's result by proving that the reciprocal of th... | | 2021 |
8 |
|
Simon, Philip C. | A study of the optimized load of a traveling wave thermoacoustic heat engine | Thermal interaction between differentially heated solid material and ambient gas in a resonator can lead to self-sustained oscillations or the transportation of heat in accordance with the thermoacoustic effect, first explained by Lord Rayleigh. In this research the phenomenon is employed in a lo... | Thermoacoustic engine - Research; Energy conservation | 2016-03 |
9 |
|
Sullivan, Steven M. | A trace formula for G2 | An n-dimensional matrix representation of a group G on a vector space V is a homomorphism from G to GL(V). For our purposes, we consider an irreducible representation to be a representation which cannot be decomposed into the direct sum of smaller-dimensional representations. Let H be a subgroup of ... | Trace formulas | 2013-05 |
10 |
|
Blanton, Joseph P. | AC Magnetic Susceptibility of Sub-Millimeter Superconductor Samples at Extreme Conditions | Superconductivity is a unique state of matter observed at cryogenic temperatures in many materials. Superconductors are defined as materials that have zero DC electrical resistance and perfect diamagnetism below a critical transition temperature, Tc. These properties are very useful for many applica... | | 2018 |
11 |
|
Shapiro, Darien | Activation of transient receptor potential ankyrin-1 by wood smoke particulate material | Exposure to wood smoke particulate matter (WSPM) has been linked to exacerbation of pre-existing respiratory conditions such as asthma, development of chronic obstructive pulmonary disease (COPD), and premature deaths. While it is clear that WSPM exposure is hazardous to human health, the molecular ... | Smoke; Physiological effect | 2012-05 |
12 |
|
Arave, Rowan A. | AKT1 activation promotes the development of melanoma metastasis | Metastases are the major cause of melanoma-related mortality. Previous studies implicating aberrant AKT (or protein kinase B) signaling in human melanoma metastases led to the evaluation of the effect of activated AKT1 expression in non-metastatic BRAFV600E/cyclin dependent kinase inhibitor 2a nu... | Melanoma; genetics; research; metastasis; genetics; research; biochemistry; genetics | 2015-12 |
13 |
|
Arnoholt, Alayna | An analysis on the influence of anxiety in post error slowing | Anxiety disorders are among the most common mental disorders and affect 15.7 million Americans each year (Lépine, 2002, p. 4). Anxiety is associated with reduced productivity, physical distress, and other diseases such as depression. Anxiety could also be influential in error response (Compton et a... | Americans | 2021 |
14 |
|
Cummins, Heather | Analysis of eyes shut (EYS) function during intestinal regeneration in drosophila melanogaster | The intestine is a self-renewing organ under constant stress. It is the first line of defense against toxins and bacteria and enables digestion and nutrient absorption. Its homeostasis (controlled regulation) plays a critical role in the maintenance of organ function and prevention of tumor generati... | diseases or cancers; homeostasis; sufficient | 2019 |
15 |
|
Zhu, Judy | Analysis of the pH-dependent equilibrium relationship between the guanine oxidation products 5-guanidinohydantoin and iminoallantoin | Oxidation of 2'-deoxyguanosine (dG) results in the major two-electron product 8-oxo-7,8-dihydro-2'-deoxyguanosine (dOG) that can undergo further oxidation to other products. One such product is 5-guanidinohydantoin (dGh) that is highly mutagenic and has been found in vivo. The ring architecture of d... | Oxidation; guanine oxidation products; 5-guanidinohydantoin; Iminoallantoin; Equilibrium relationship | 2015-05 |
16 |
|
Rohaj, Aarushi | Apoptosis efficiency of the transfected elephant and human P35 vectors in P53 varying leiomyosarcoma cells | Comparative Oncology is an approach that integrates and connects commonly occurring cancers seen in animals, into studies focused on cancer biology, prevention, and treatment in humans. Studies show that natural mechanisms can suppress cancer 1,000 times more adequately in certain animals than in hu... | | 2021 |
17 |
|
Edwards, Jennifer Lynn | Application of a TBHP-mediated Wacker-type oxidation to internal alkenes | The Wacker oxidation allows access to methyl ketones from terminal alkenes. This transformation is important for industrial, synthetic, and medicinal chemists, as carbonyls are present in many natural and pharmaceutical products. With the carbonyl, a wide variety of reactions become available, such ... | Wacker-type oxidatioin - Research; TBHP | 2013-05 |
18 |
|
Pecchia-Bekkum, Annika | Applications of controlled DNA assembly and disassembly in biosensing and responsive drug delivery | Deoxyribonucleic acid (DNA) provides many exciting functions outside of simply encoding genetic information. Herein, we report two techniques to control the assembly and disassembly of nucleic acids. Within these techniques, DNA is used as a programmable material for biosensing and drug delivery. In... | Nucleic acids - Biotechnology | 2013-08 |
19 |
|
Stahulak, Robert J. | Applying Chiral Field Theory to Neutron Star Moments of Inertia | In this work we examine the applications of neutron stars and their unique structure toprovide limits on the range of possible equations of state which describe nuclear matter.We follow the history of developments in nuclear physics and discuss the current state ofknowledge of neutron stars, includ... | | 2019 |
20 |
|
Stahulak, Robert J. | Applying chiral field Theory to Neutron Star Moments of Inertia | In this work we examine the applications of neutron stars and their unique structure to provide limits on the range of possible equations of state which describe nuclear matter. We follow the history of developments in nuclear physics and discuss the current state of knowledge of neutron stars, incl... | | 2019 |
21 |
|
Renz, Andy | Assessment of exercise-stimulated tissue oxygenation in calf muscle with functional MRI | Peripheral artery disease (PAD) affects millions of patients in the USA, and effective diagnosis and management of PAD is a major clinical goal. One promising avenue of research towards the goal is through functional MRI, which provides non-invasive measurement of tissue oxygenation. For a group of ... | Arteries - Diseases - Diagnosis; Magnetic resonance imaging - Research; Calf muscle; Peripheral arterial disease; MATLAB | 2016-04 |
22 |
|
Estrada, Johanna | BCR-ABL1 compound mutations combining key kinase domain positions confer clinical resistance to ponatinib in Philadelphia cromosome-positive leukemia | CML 1s caused by a random reciprocal translocation that joins the ABL1 gene on chromosome 9, with the BCR gene on chromosome 22. The result is the formation of the oncogenic BCR-ABL1 gene. This derivative chromosome is widely known as the Philadelphia Chromosome (Ph+), and it encodes a deregulated, ... | Leukemia -- Genetic aspects -- Research Leukemia -- Treatment -- Research | 2014-04 |
23 |
|
Zhao, Michael | Binary Hermitian Forms and Optimal Embeddings | Let L=K be a quadratic extension of global fields, and OL the ring of integers of L. We prove two correspondences between (i) binary L-hermitian forms which represent 1 and optimal embeddings of L into a quaternion algebra, (ii) integral binary OL-hermitian forms which represent 1 and embeddings of ... | | 2017 |
24 |
|
Burga, Carlos Alberto | Binary superlattices of semiconductor nanocrystals : a path towards possible high-temperature superconductivity | This thesis provides a platform to experimentally test Dr. Daniel Mattis' theoretical work on the possible superconductive behavior of nanostructured intrinsic semiconductors1-2. The theoretical work hinged on the nano-scale architecture of semiconductors. Therefore, using various types of semicondu... | Semiconductor nanocrystals; Superconductivity; Superlattices as materials | 2013-05 |
25 |
|
Rose, Steven | Biofuel cells for self powered arsenic detection | Research in the Minteer group has centered on procedures for immobilizing enzymes and organelles on carbon electrodes for use in sensory and fuel cell applications. Similar strategies have been used to prepare a series of electrodes capable of pyruvate oxidation which, in the presence of arsenic, wi... | Fuel cells; Arsenic - Detection | 2013-05 |
26 |
|
Tazehabadi, Tara | Bioinformatics to detect functional interactions important for the DNA repair enzyme mutyh | DNA is the blueprint of all biological life as it provides the means necessary for sharing of genetic information. DNA is formed and stabilized by interactions between four unique bases, Adenine (A), Cytosine (C), Guanine (G), and Thymine (T) which come together in predetermined patterns to create a... | | 2022 |
27 |
|
Beseris, Ethan | Biological impact protection in human facial hair | Our study investigated selective mechanisms that influenced the evolution of facial hair in human males (Homo sapiens). Beards are often perceived as an indicator of masculinity and social dominance in men, suggesting that they may play a role in male contest competition. Some authors propose that t... | | 2018 |
28 |
|
Galinat, Shelby | Bipyrimidine solubility modeling for applications in NON-Aqueous redox flow batteries | Energy storage research has undergone transformative changes in the past 50 years. The increasingly concerning threat of climate change has emphasized the need for energy storage technology to facilitate renewable energy incorporation into the grid. Without energy storage, the fluctuations of wind a... | | 2022 |
29 |
|
Ellingson, Drew | Bitangent lines to planar quartic curves in algebraic and tropical geometry | Bitangents are lines which are tangent to a curve at two points. The bitangents of a classical quartic are well understood, and a result originally due to Cayley tells us that there are always precisely 28 bitangents to a generic quartic plane curve. When looking at Tropical Geometry, the situation ... | Tropical geometry; Curves, Quartic; Curves, Algebraic; Bitangents | 2015-04 |
30 |
|
Simonsen, Kyle | Breast cancer knowledge and attitudes among women in Armenia | Background: Breast cancer, the most common invasive cancer among women, has high incidence and mortality rates among women in the Republic of Armenia. Advanced stage at detection limits treatment options and contributes to high morbidity and mortality. Understanding women's breast cancer knowledge a... | Breast - Cancer; Breast - Cancer - Patients - Attitudes; Breast - Cancer - Patients - Armenia (Republic) | 2013-07 |
31 |
|
Furrer, Summer | Cellular and subcellular localization patterns of hepatitis delta virus in sjogren's syndrome salivary gland tissue | Primary Sjogren's syndrome (pSS) is an autoimmune disorder, predominantly affecting women, that causes dry eyes, dry mouth, fatigue, and other extraglandular manifestations (Le Goff et al., 2017). It has been shown that chronic pathogen exposure can lead to development of autoimmune diseases such as... | | 2022 |
32 |
|
Thomas, Nikita | Cellular ultrastructure of C. elegans nervous system | Determining the ultrastructural organization of the nervous system is a key step in understanding how complex behavior is generated. For a nervous system to function, it must be wired accurately. A complete wiring diagram, referred to as a connectome, can be created by tracing neuronal profiles thro... | Caenorhabditis elegans - Nervous system | 2013-05 |
33 |
|
Jensen, Madeline | Changes in microbial diversity in storm-water green infrastructure | Increased urbanization has led to excess nutrients in urban ecosystems. Stormwater Green Infrastructure (SGI) is a method to capture these nutrients and prevent runoff. However, an increased understanding of ecosystem processes is needed to create more efficient SGIs. Past studies have shown that pl... | | 2022 |
34 |
|
Wu, Tingshiuan C. | Characterising the Matched-Runs Method for Analysing Images of Extended T-Ray Sources using Veritas | The matched-runs method of performing high-resolution imaging of extended very high-energy (VHE, E>100 GeV) γ-ray sources using the Very Energetic Radiation Imaging Telescope Array System (VERITAS) is characterized in this study. Several extended VHE γ-ray sources have been detected by the Milagro... | | |
35 |
|
Gondolo, Alessandro | Characterization and Synthesis of Rayleigh Damped Elastodynamic Networks | We consider damped elastodynamic networks where the damping matrix is assumed to be a non-negative linear combination of the stiffness and mass matrices (Rayleigh damping). We give here a characterization of the frequency response of such networks. We also answer the synthesis question for such netw... | Damping (Mechanics) - Mathematics | 2013-05 |
36 |
|
Barbeau, William | Characterization of a New Ribosome Associated Quality Control Pathway | Proteins are life's double edged sword. Proteins are essential macromolecules of life, and the tasks that some proteins accomplish are quite marvelous. At the same time, if proteins misfold they have the potential to kill the cell that harbors them. It is becoming increasingly clear that proteins ha... | Ribosomes - Research | 2016-12 |
37 |
|
Visser, Joshua | Characterization of G-quadruplexes in DNA repair protein gene sequences and the effects of oxidized guanine lesions on DNA base insertion and elongation | Guanine (G) is one of the four nucleo bases that make up the complex macromolecule deoxyribonucleic acid (DNA). In addition to its ability to Watson-Crick base pair with cytidine (C), guanine can base pair with itself vianon-canonical, Hoogsteen base pairing and form a secondary structure of DNA ca... | DNA repair - Research; G proteins - Pathophysiology - Research; Oxidation, Physiological - Research; Membrane homogenization; Synthetic blood; Artificial oxygen carriers | 2016-05 |
38 |
|
Nicolo, Tera | Characterization of mitochondria-modified electrodes | In order to develop an herbicide sensor, yeast, potato, and bovine heart mitochondria were isolated and immobilized onto Toray paper electrodes. Cyclic voltammetry showed two redox peaks at 186 ± 14 mV vs. SCE and -357 ± 24 mV vs. SCE with an E1/2 of -128 mV. Scan rate studies suggested the proces... | Electrodes; Herbicides - Detection | 2013-05 |
39 |
|
Bell, Marisa | Characterization of Polyphenols in I. Umbellifera | Secondary metabolites in plants, including polyphenolics, may be responsible, in part, for diversity in the tropics. Variation in chemical defense among species of trees encourages specificity in herbivorous insects. Due to the short lifespan of insects compared to trees, diversity in chemical defen... | | 2018 |
40 |
|
Little, Nancy Ann | Characterizing and mapping l(3)7E103 a gene required for Drosophila dorsal closure | Dorsal closure in the fruit fly Drosophila melanogaster is a complex morphogenetic process dependent upon three embryonic tissues: the lateral epidermis, leading edge epidermis, and amnioserosa. Additionally, the Jun N-terminal Kinase (JNK) and Decapentaplegic (Dpp) signaling cascades are required f... | Drosophila melanogaster - Genetics; Drosophila melanogaster - Embryology | 2013-05 |
41 |
|
Richards, Jackson | Chasing channels: Progress in calcium channel localization in the C. Elegans synapse | Calcium channels play a crucial role in neurotransmission by facilitating the flow of calcium ions necessary for synaptic vesicle fusion and neurotransmitter release. Different types of calcium channels participate in this process in the neurons of the nematode C. elegans. L- and N-type channels res... | Calcium channels; Synaptic vesicles; Caenorhabditis elegans | 2013-05 |
42 |
|
Samuelson-Lynn, Moses | The classification of surfaces | | | 2024 |
43 |
|
Yamada, Kaylene | Comparing Tollerance of Neotoma Lepida on Native Versus Novel Toxic Diets | Herbivorous animals often ingest plants that protect themselves with chemicals, and these toxins typically differ in composition from plant to plant. For instance, juniper (Juniperus osteosperma) is dominated by terpenes, such as α-pinene, whereas creosote bush (Larrea tridentata) contains a cockta... | | 2017 |
44 |
|
Odendahl, Nathan | Comparison of popular force fields for molecular modeling of proteins applied to ice binding of the tenebrio molitor antifreeze protein | Ice Binding Proteins (IBPs) are a class of proteins that affect the melting and freezing temperatures of ice. While substantial research has been conducted to understand the properties of IBPs, experimental and molecular dynamics simulations have not satisfactorily explained the mechanism of the i... | Antifreeze proteins - Research; Ice binding proteins; Tenebrio molitor; Antifreeze protein; Force fields | 2016-04 |
45 |
|
Neville, Roselyn | Constitutively activated AKT is not sufficient to keep cells alive following epithelial cell extrusion | The PI3 kinase (PI3K)/AKT signaling pathway regulates many fundamental behaviors of the cell. If any of the key members of this pathway are deregulated, it can lead to malignant changes in the cell. AKT enhances the survival of cells by inhibiting pro-apoptotic processes, and promoting pathways for ... | PI3K/AKT - Chemistry; Cancer metastasis | 2014-05 |
46 |
|
Christensen, Masen | Cooperative primers: Intersecting spherical model for optimization of linker and gap lengths | Detection of specific sequences of DNA is invaluable for diagnosing the presence of a pathogen, as well as other areas of genetic analysis. A common way of detecting DNA is replicating it millions of times through Polymerase Chain Reaction (PCR) and using fluorescent molecules to detect those copies... | Pathogenic microorganisms - Detection; DNA - Research; Polymerase chain reaction - Research; Cooperative primers; Aluminum foam materials; Load frame | 2016-05 |
47 |
|
Besic, Arnel | Creation and characterization of organic mixed conductors | Organic mixed ionic electronic conductors (OMIECs) are conjugated polymers that conduct both ions and electrons. These materials are promising for applications in healthcare and energy technologies, including biosensors and batteries. An obstacle for using these materials in next-generation technolo... | | 2024 |
48 |
|
Evans, Kathryn S. | Defining the interaction between ETV4 and mediator subunit MED25 | Chromosomal rearrangements resulting in an overexpression of a subset of ETS transcription factors (ETV1, ETV4, ETV5, and ERG) are found in over 50% of prostate cancers (Tomlins et al., 2005). ERG and ETV1 have both shared and distinct gene targets, yet overexpression of ETV1 is often found to be as... | Transcription factors; Prostate -- Cancer -- Genetic aspects; ETV4 | 2015-05 |
49 |
|
Peterson, Joseph Ryan | Deflagration and detonation modeling of heterogeneous condensed phase explosives | A modeling approach to the deflagration and detonation phenomena is employed to study a variety of explosive scenarios. An engineering model for macroscale reaction of energetic materials over the wide range of explosive reaction from deflagration to detonation is developed based upon solid foundati... | Deflagration phenomena; Detonation phenomena; mesoscale model | 2012-05 |
50 |
|
Lim, Koun (Kasha) | Deglycoyslation of glucose oxidase and its application within high power enzymatic fuel cells | To compensate for the increase of carbon dioxide level and the energy exhaust, an enzymatic fuel cell (EFC) has been investigated by researchers. In the paper, a chemical oxidative deglycosylation of an enzyme was investigated to furture improve EFCs. By deglycosylating an enzyme, the distance betwe... | Fuel cells - Research; Electric power - Research; Deglycosylation; Enzymatic fuel cell; Glucose oxidase | 2016-04 |
51 |
|
Baker, Justin | Designed Swarming Behavior Using Optimal Transportation Newworks | Models of swarming behavior aid in disaster planning, direct the actions of ware- house robots, and can map the foraging characteristics of insects. These mod- els use the optimal behavior of individual agents to determine the behavior of the larger population. Optimal transportation is one such mod... | | 2019 |
52 |
|
Munn, Jackson | Determining microbial community composition and methane flux or red butte canyon sediment over time | Methane is a potent greenhouse gas that is released from the soil into the atmosphere, which contributes heavily to global warming. One potential way of reducing the amount of methane in the air is through studying methane consuming bacteria (methanotrophs) and how they interact with other microbes ... | | 2022 |
53 |
|
Sanders, Sara | Development of a novel, coumarin-europium sensor for reactive oxidizing species | The synthetic framework has been developed for two fluorescent probes of Reactive Oxidizing Species (RoxS) based on a coumarin-europium fluorescence pair. The coumarin moiety's selectivity for hydrogen peroxide coupled with 620 nm shifted emission of the europium will make these novel sensors biolog... | Reactive Oxygen Species - analysis | 2012-05 |
54 |
|
Lutz, Kevin | Discovery of platinum (II) cocrystals with highly fluorinated cyanocarbons | This thesis investigates new platinum(II) complex cocrystals with highly fluorinated cyanoaromatics. While π stacking compounds of polycyclic aromatic hydrocarbons and cyanoaromatics have been reported, interactions with transition metal complexes have yet to be explored. Crystal structures for (pp... | | 2023 |
55 |
|
Gardner, Jenna | The Disparity Between Student Science Writing and Professional Sciencetific Writing | There exists a disparity between student scientific writing and professional scientific writing. The audience, format, and intention of student papers as presented in the science classroom is different from those in the scientific field where the goal is to fully convince an unfamiliar audience and ... | | 2017 |
56 |
|
Chen, Jason J. | Dissecting the genetic and learned components of oscine birdsong | The interplay of genetically encoded and learned components in the development of the learned vocal signals of birdsong and human speech in not fully understood (Forstmeier et al, 2009). The fact that song is a learned vocal behavior does not imply the lack of a genetic basis in acquiring vocalizati... | Birdsongs -- Research; Songbirds -- Genetics -- Research; Zebra finch -- Research; Nature and nurture -- Research; birdsong; Taeniopygia guttata | 2015-12 |
57 |
|
Dart, Emily | Diversity and metabolic potential of microbial communities in a site of continental serpentinization | The geochemical process of serpentinization releases energy and organic carbon: two of the basic requirements need ed to support life. Sites of active serpentinization in the deep subsurface provide the intriguing possibility of a non-photosynthetically -supported biosphere. However, serpentinizatio... | Microbial ecology - Research; Serpentine - Environmental aspects; Gros Morne National Park (N.L.); Syntrophomonadaceae; Serpentinizaiton; Tabeland Ophiolite | 2016-05 |
58 |
|
Kent, Alexandra | DNA split aptamers as a biosensing platform for the detection of small drug molecules | Prescription drug overdose and abuse is a leading cause of death in the United States. It is a serious issue and has become increasingly problematic as opioids are being prescribed with a higher frequency. For this reason, fast, accurate detection of small drug molecules is crucial. The current stan... | Drug testing; Biosensors; DNA split aptamers | |
59 |
|
Kim, Bum Jun | Does ceramide contribute to vascular dysfunction in mice with type 1 diabetes? | Approximately 2 million individuals have type 1 diabetes (T1D) in the United States. Cardiovascular disease is 2-4-fold more prevalent in these patients but the mechanism(s) is unclear. Recently, we showed that the sphingolipid ceramide contributes to arterial dysfunction and hypertension in mice wi... | Ceramide - Research; Type 1 Diabetes; Mice as laboratory animals | 2012-05 |
60 |
|
Verhaaren, Molly | Double-checking: a statistical analysis of twenty-first century U.S. election recounts | Election recounts are an integral part of voting history in the United States. Initiated by the political jurisdiction or by the candidate, they have the power to overturn previously decided election results and have done so on more than one occasion. However, that power may not be worth its price a... | | 2021 |
61 |
|
Kim, Alexander H. | DPP Signal Regulation Through O-Linked Glycosylation | Dorsal closure in Drosophila is an embryogenic event that involves coordinated cellular shape changes. A series of interconnected signaling cascades are utilized to accomplish this task, one of which is the Decapentaplegic (Dpp) pathway. Dpp is a member of the TFG-β family of secreted cytokines, wh... | | 2017 |
62 |
|
Ballif, Micah | Drugs and Pregnancy: Clinical Management with a Cystic Fibrosis Focus | Despite the large number of women who become pregnant and use a medication during their pregnancy, there is very little information about the safety of the majority of medications. Most drugs approved by the FDA have undetermined teratogenic risk, but their use is prevalent in the management of dise... | Physicians; University of Utah Hospital's; antibiotics | 2019 |
63 |
|
Zheng, Kenneth | Dyck Paths and Random Trees | We give an expository survey of random trees, focusing on the interplay between plane trees and Dyck paths. The material explained here summarizes what can be found in Aldous [1], Le Gall [10], and Drmota [6]. The bijection between plane trees and Dyck paths serves as motivation for the connection b... | | 2017 |
64 |
|
Prestgard-Duke, Michael | Dynamin localization in Caenorhabditis Elegans | Dynamin is a 100-KDa GTPase that is essential for endocytosis. The classic model of endocytosis is a sequential mechanism: first, cell membrane is bent and internalized via the formation of a clathrin coat; next, dynamin facilitates GTP hydrolysis, resulting in membrane scission as the newly formed ... | Caenorhabditis elegans; Guanosine triphosphatase; Endocytosis | 2014-05 |
65 |
|
Curtis, Kaili Breann | The Effect of Inflammatory Components on Influenza a Virulence Evolution | The methodology for passaging influenza A virus in the mouse model has widely been established. However, traditional infection methods involving the inoculation of lung homogenates fail to account for the possible effects of host-associated factors on measures of virulence and in the virulence evolu... | | 2020 |
66 |
|
Azadpour, Elmera | The Effect of Inorganic VS Organic Fertilizer on an Urban Lawn in Salt Lake City, Utah | While lawn management practices have altered the capacity for urban lawns to act as Nitrogen (N) sinks, there have been few studies of the effects of organic vs. inorganic fertilizer additions to urban lawns. We evaluated how foliar and soil N content and isotopic N composition (δ15N) varied as a r... | | 2019 |
67 |
|
Kasera, Shalini | Effect of IUGR and supplemental DHA on molecular mediators of hepatic lipid accumulation in the rat | Intrauterine growth restriction (IUGR) refers to failure of the fetus to achieve its genetic growth potential in utero and is commonly caused by uteroplacental insufficiency secondary to maternal hypertensive disorders. A hallmark of IUGR is a decrease in circulating docosahexaenoic acid (DHA), an �... | | 2022 |
68 |
|
| Effects of Acute Hypoxia and High pCO2 on Total Protein Content and Metabolic Enzyme Activity in Rockfishes (Sebastes SPP.) | Climate change is altering ocean chemistry and wind-driven upwelling regimes. In the California Current System (CCS), these changes are exposing nearshore fishes to increasing levels of high pCO2 and hypoxia. These stressors co-occur during upwelling events, lasting hours to days, and both have the ... | | 2019 |
69 |
|
Smith, Sarah | Effects of Mitochondrial Mobility on Astrocyte Function | Within the brain, astrocytes provide support and influence the excitability of neurons by regulating the extracellular levels of potassium (K+) and glutamate. These glial cells play a vital role in neural homeostasis by regulating the concentration of neurotransmitters at the synapse, therefore modu... | | 2018 |
70 |
|
Lebrecht, Maranda | Effects of ventilatory regimens on the prevalence of a common gastrointestinal disease in neonates | Necrotizing Enterocolitis, or NEC, is a common intestinal disease of preterm neonates. It is believed that bacterial colonization increases the risk of NEC. This study examines whether the type of ventilation of the neonate, either mechanical ventilation (MV) or non-invasive support (NIS), and the ... | Enterocolitis, Neonatal necrotizing - Research; Newborn infants - Diseases; Sheep as laboratory animals - Research; Necrotizing enterocolitis; Lymphocytes | 2016-05 |
71 |
|
Muehlman, Jayanti | Effects of Wind-Generated Underwater Noise on Southern right Whale Group Dynamic | The goal of this study was to investigate whether underwater noise affects the grouping behavior of southern right-whale (Eubalaena australis) mother-calf pairs at Península Valdés, Argentina. This area is a major calving ground for the population that occupies the western South Atlantic. Two larg... | | 2020 |
72 |
|
Bischoff, Amanda | Elucidating the Mechanism and Predicting the Selectivity of the bis(Pyridine) Silver Permanganate Oxidatiin | The Movassaghi group has recently reported several total syntheses of epipolythiodiketopiperazine derivatives (ETPs), a class of natural products with potent biological activity. A crucial step in their synthesis oxidizes two to four tertiary C-H bonds to form tertiary alcohols using (bis)pyridine s... | | 2016 |
73 |
|
Mercer, Marianne | Establishing a System for Structure-Function analysis of the Novel Role that NUP153 Plays in Nuclear Assembly | In mitosis, equal partitioning of DNA between daughter cells requires an integrated series of events. At the start of anaphase the chromatin separates and forms two chromatin discs. This chromatin is then targeted by nuclear membrane proteins and membrane to form the nuclear envelope. These membrane... | | 2018 |
74 |
|
Cocke, Rebecca C. | Evaluating the Catalytic Activity of Iron and Nickel Impurities in Bare High-Pressure High-Temperature Nanodiamond | Many metal nanoparticles are used as catalysts for various reactions and are held on supports. High-Pressure High-Temperature nanodiamonds (HPHT ND) are able to support metal nanoparticles even under strenuous chemical environments due to their robust nature. The production of HPHT ND includes the u... | | 2018 |
75 |
|
Fernandez, Florence | Evaluation of environmental education in high school science courses across Salt Lake City, Utah | While the effects of pollution become Incredibly more evident in the air of the Salt Lake Valley, many Utah high school students still lack the knowledge and information necessary to take preventative and immediate actions to protect their health and their environment. In this study, the reasons for... | Environmental education -- Utah -- Salt Lake City; Science -- Study and teaching -- Utah -- Salt Lake City; Air -- Pollution -- Utah -- Salt Lake City | 2015-05 |
76 |
|
Fan, Huijun | Examination of Y-Deterium isotope effects for the solvolysis of model isoprenoid compounds | Model isoprenoid compounds can undergo two distinct pathways, dissociative or associative nucleophilic substitution depending on the conditions used. The dissociative pathway consists of two steps, involving a carbocation intermediate where the formation of that carbocation is rate determining. The ... | Isopentenoids; Solvolysis; Deuterium - Isotopes | 2012-05 |
77 |
|
Turner, Jackson | Expansion method for eigenvalue problems: theories, algorithms, and applications | The Laplacian operator plays a ubiquitous role in the differential equations that describe many physical systems. These include, for example, vibrating membranes, fluid flow, heat flow, and solutions to the Schrödinger equation. In this paper, we investigate a method to find the eigenfunctions of t... | example; computation | 2021 |
78 |
|
Bell, Anthony W. | The expansion of pinyon-juniper woodland and the appearance of peromyscus truel in the Toiyabe range of central Nevada | In the early twentieth century field biologists from the University of California Museum of Vertebrate Zoology conducted vertebrate faunal surveys throughout the Great Basin region. Over the past several years we have been conducting resurveys of many of the localities visited by MVZ scientists. Our... | Piñon mouse -- Nevada -- Toiyabe Range; Piñon mouse -- Habitat -- Nevada -- Toiyabe Range; Piñon mouse -- Climatic factors -- Nevada -- Toiyabe Range | 2012-05 |
79 |
|
Spurlock, Ella K. | Exploration of the 2-dimensional π-d conjugated coordination polymer Cu-benzenehexathoil | Coordination polymers (CPs) are a type of atomically precise material that has long been an area of study for materials chemists. Recently, research has advanced with twodimensional conjugated CPs as detailed synthetic schemes are developed to create highly atomically ordered, large-area sheets. The... | | 2022 |
80 |
|
Garcia, Anthony D. | Exploring galactic chemical abundance of phosphorus in the ultra-violet with HST | Ultra violet observed spectral data taken by the Hubble Space Telescope (HST) are made available to the public. These data sets have been extracted into one-dimensional and flux-calibrated spectral data, and are ready for analysis. We have normalized the extracted spectra with a Planck black body cu... | Milky Way - Phosphorus content | 2014-05 |
81 |
|
Davis, Kacey A. | Expression and Purification of Augertoxins: Searching for Novel Protein Folds in Venomous Marine Snails | This study describes a method for bacterial expression and purification of previously uncharacterized proteins. The proteins chosen for this study come from auger snail toxins, which have evolved to help the snail hunt and kill their prey. Evolutionary pressure between predator and prey selects for ... | | 2018 |
82 |
|
Coplan, Caitlin Denise | Fabrication and Application of Aluminum Nanostructures | Plasmonics, the phenomenon resulting from light interactions with nanoscale structures, is an active field for nanoscale manipulation of light. By varying the metal, size, and shape, plasmonic nanostructures can be tuned to interact with a broad spectral range of light. Commonly used plasmonic mater... | spectroscopies; photocatalysis; photovoltaics. | 2019 |
83 |
|
Borodai, Anastasia S. | Faraday @ Home Continuing Faraday from the "U" to the Youth | Recent attention has been brought to light in the United States regarding the lack of students pursuing STEM disciplines and degree programs. There is a considerable amount of research on the importance of STEM (Science, Technology, Engineering and Math) Education at an early onset age. With this is... | | 2017 |
84 |
|
Ridge, Rachel Katherine | Flagellar Protein Flhe Influences Motility and Morphology Through Regulation of Assembly in Escherichia Coli | The bacterial flagellar motor is a remarkably complex system, comprising thousands of protein subunits and responsible for motility in numerous species. Of these proteins, FlhE is not universally conserved and is relatively understudied. Usually found cotranscribed with flhB and flhA in the flhBAE o... | | 2017 |
85 |
|
Chure, Griffin Daniel | FLHE influences cellular morphology through control of flagellar assembly in escherichia coli | The bacterial flagellar motor is a complex nanomachine composed of thousands of individual protein subunits. One of these proteins, FlhE, has not been studied in depth and its function is not completely understood. The flhE gene is cotranscribed with flhB and flhA in the flhBAE flagellar operon. In ... | Escherichia coli; Flagella (Microbiology) | 2013-05 |
86 |
|
Bowen, Brady | Fractal geometry of melt ponds: Modeling the fractal geometry of arctic melt ponds using the level sets of random surfaces | During the late spring, most of the Arctic Ocean is covered by sea ice with a layer of snow on top. As the snow and sea ice begin to melt, water collects on the surface to form melt ponds. As melting progresses, sparse, disconnected ponds coalesce to form complex, self-similar structures which are c... | Melt pond geometry | 2016-04 |
87 |
|
Johnston, Jessica Faith | From nanoscience to astrophysics: using high-resolution microscopy and spectroscopy of carbonaceous chondrites to understand planet formation | In the field of astrophysics, there currently exists an outstanding gap of knowledge in understanding planet formation dynamics. At the formation scale ranging from millimeters to meters, astrophysicists debate as to how solar nebulae form larger masses-planets and other kilometer-sized bodies-from ... | Physics & Astronomy | 2012-05 |
88 |
|
Narasipura, Eshan Amruth | Full synthesis of enzymatically cleavable linker between 929-designed ankyrin repeat protein and 17-dimethlyamino geldanamycin | Targeted cancer therapeutics are an important and promising field of cancer research due to their ability to reduce the off target effects produced in other therapies such as chemotherapy. Antibody Drug Conjugates (ADC) are one such therapeutic that specifically target cancer cells through antibody-... | | 2021 |
89 |
|
Pham, John V. | The function of the protein VCP/CDC48-associated mitochondrial stress-responsive 1 in mammals | Although mitochondrial dysfunction has been linked to many human diseases, mitochondrial interacting proteins and protein quality controls are just beginning to be understood. The objective of our study was to characterize the function of the VMS1 protein in mammals. We determined the role of Vms1 o... | Mitochondrial disorders; Mitochondrial diseases - genetics; VMS1 | 2012-05 |
90 |
|
Capener, Jacob | G Protein-Coupled resecptor kinase 2 mediated phosphorylation for The Activation of Smoothened | The Hedgehog (Hh) pathway is a cell signaling pathway that is involved in embryonic development and adult tissue maintenance in vertebrates. Improper functioning of this pathway can lead to developmental disorders and several forms of cancer. Despite the pathway's biological importance, the transduc... | | 2020 |
91 |
|
Imig, Julie | Galactic Evolution of Phosphorus and Sulfur Using Star Clusters | The chemical composition of a galaxy changes as it evolves, so understanding the evolutionary processes of individual elements can be powerful tools in unravelling the history of a galaxy. Phosphorus is considered one of the key building blocks of life, and sulfur is an alpha-element, a tracer of su... | | 2017 |
92 |
|
Borrowman, William | Gas exchange of co-occurring plant species of the Great Basin Desert in an irrigated common garden | The majority of plants in the Great Basin ecosystem have adapted to cope with drought during summer. While general characteristics of these plants have been studied in non-managed environments it is important to investigate the physiology of these plants when additional water is supplied. In this ... | Urban heat island -- Prevention; Desert plants -- Ecology -- Great Basin -- Research; Plant ecophysiology -- Research; Irrigation -- Environmental aspects; Red Butte Garden (Salt Lake City, Utah) | 2014-04 |
93 |
|
Loret, Amy | Genetic Modifiers of Severity in Collagen VI-Related Muscular Dystrophy | Collagen VI-related muscular dystrophies (COL6-RD) display phenotypic heterogeneity that includes mild Bethlem myopathy (BM), intermediate (INT), and severe Ullrich congenital muscular dystrophy (UCMD) phenotypes. COL6-RD are characterized by mutations within the collagen VI genes (COL6A1, COL6A2, a... | heterogeneity; characterized; Resulting symptoms | 2019 |
94 |
|
Rahmati, Kasra | Genetically Modified Chemotaxis Signaling Protein Chey Binds to the Rotor Protein Flin to Control the Direction of Flagellar Rotation in Escherichia Coli | Bacterial chemotaxis is the directed movement of a bacterium in response to environmental chemical stimuli. Cells of E. coli, for example, swim by rotating their flagella and direct their movement by regulating reversals between counterclockwise (CCW) and clockwise (CW) rotation. The switch from CCW... | | 2020 |
95 |
|
Acosta, Lehi | Genotype-dependent susceptibility to influenza and titer-virulence discordance | The influenza a virus (IAV) is a major source of human mortality and both recent and anticipated pandemics make understanding this major human pathogen of paramount importance1,2. The use of mouse models allows us to experimentally manipulate critical variables to more fully understand the dynamics ... | Influenza A virus - Research; Mice as laboratory animals - Research; Transmissibility; Virulence; Viral titers; Erythropoeintin | 2016-05 |
96 |
|
Le, Bao Gia | The geometry of bivariate splines on triangulated polygons | | | 2022 |
97 |
|
Fischer, Paul | High-Performance Computing Performance Metric Analysis | At present, a signi#12;cant amount of ongoing scienti#12;c research relies on computational models. High-performance computing (HPC) resources are often required to obtain results in a reasonable amount of time. However, as physical and practical limitations constrain the performance progression of ... | | 2019 |
98 |
|
Kutschke, Michael | Hip joint center differences between dual fluoroscopy, functional hip, and coda - establishing a reference standard | Measurements of joint angles, moments, and forces may be highly sensitive to positional changes in the center of a joint. Due to its deep location, the human hip joint center (HJC) can be difficult to determine. Previous studies have defined the HJC relative to external landmarks using infrared moti... | Hip joint; Hip joint center | 2015-05 |
99 |
|
Thomas, Nathaniel | The HIV-protective bystander effect in macrophages is viral glycoprotein dependent and likely conferred via upregulation of ISG IFITM3 | During an immune response against a specific antigen, often during viral infections, T cells not specific to the antigen can be activated, a phenomenon known as bystander response. The "bystander response" has been studied extensively in T cells, but when examined for macrophages through the lens of... | | 2022 |
100 |
|
Jones, Kathryn K. | Hybrid Enzyme-Bimetallic Nanoparticle System for Tandem Oxidation Catalysis | Metallic nanoparticles are commonly used as catalysts in industrial and academic settings. Recent observations that bimetallic nanoparticles can have enhanced activity over their monometallic counterparts has increased the interest in their synthesis and application to new catalytic systems. Combini... | | 2020 |
101 |
|
Lan, Yung-Chi | HYPO-osmolarity and glucose starvation localizes slm1 to mitochondria- A novel stress response pathway | Synthetic Lethal with Mss4 1 (Slm1) is a key protein found in the crossroad of the Membrane Compartment of Can1 (MCC) and the Membrane Compartment of TORC2 (MCT). The two compartments on the plasma membrane of budding yeast (Saccharomyces cerevisiae) are responsible for APC transporter regulation an... | | 2022 |
102 |
|
Weaver, Bradley | Hypoxia and the mesenchymal transition in glioma | Recent advances in targeted therapy for cancer have had little influence on survival for patients diagnosed with Glioblastoma (GBM, WHO Grade IV tumors), and median survival time remains stagnant at 12-15 months post diagnosis. Genomic profiling of GBM indicates clear phenotypic subsets of these tum... | Glioblastoma multiforme; Gliomas; Hypoxia; Mesenchymal transition | 2014-04 |
103 |
|
Fackler, Anderson N. | Identification of Kin-20 and UNC-119 Knockout suppressors associated with neuronal development and maintenance in C. elegans | Neurons comprise the nervous system-the essential signaling and communication system for nearly all multicellular organisms. To coordinate cells across an entire organism, they must grow to be relatively long. Therefore, neurons extend axons from the cell body. Immature neurons extend growth cones a... | | 2018 |
104 |
|
Johnson, KariAnne Rencher | Identification of PASK substrates and/or interacting proteins | PAS kinase (PASK) is an evolutionary conserved serine/threonine kinase that appears to have a role in the regulation of cellular energy metabolism. It has previously been shown that mice lacking PASK (PASK"/_ mice) are resistant to the development of hepatic steatosis (lipid accumulation in the live... | Biology | 2012-05 |
105 |
|
| Identification of potential causes for increased central line associated bloostream infection rates in the University of Utah NICU | The University of Utah Newborn Intensive Care Unit (UUNICU) has seen a recent increase in rate of Central Line Associated Bloodstream Infection (CLABSI) after an extended period of 965 days with no CLABSI's. Unfortunately, in the last three years, infection rate has been on average 2.6 CLABSI per ye... | | 2023 |
106 |
|
Black, Alyssa | Identifying hybrid male sterility genes in Drosophila Pseudoobscura | Speciation, the process of one species splitting into two separate species, often involves the evolution of hybrid sterility or hybrid inviability. These reproductive isolating barriers are caused by negative interactions between genes called hybrid incompatibilities. Identifying hybrid incompatibil... | Infertility, Male -- Genetic aspects Drosophila pseudoobscura -- Genetics Male sterility genes | 2015-05 |
107 |
|
Ong, Elaine | Identifying Natural Genetic Modifiers of Apoptosis and Retinal Degeneration | Apoptosis, or cell death, is an integral part of many diseases such as neurodegeneration, retinal degeneration, and cancer, yet it is unclear how apoptosis varies among individuals in a population. Retinitis pigmentosa (RP) is a retinal degeneration disease characterized by phenotypic heterogeneity ... | | 2018 |
108 |
|
Khuu, Scott | Identifying Retinoic Acid Dependent Mechanisms of Neural Crest Epithelial-Mesenchymal Transition | Cancer metastasis is one of the distinguishing traits that make the disease difficult to treat. The steps of tumor invasion are similar to a process called epithelial to mesenchymal transition (EMT). Retinoic acid (RA) is shown to inhibit EMT and may cause an increased transcription of the gene, ski... | | 2017 |
109 |
|
Wang, Wenyi | Imaging in a homogeneous aluminum plate by using ultrasonic waves | This project is about detecting and imaging damage (such as cracks) in a plate by using ultrasonic waves. The waves are generated by a source (an ultrasonic transducer) that is part of a robot that can move on the plate. The waves traveling in the plate are recorded at a receiver (another ultrasonic... | Ultrasonic transducer - Mathematics; Kirchoff migration - Research | 2014-12 |
110 |
|
Au, Alexander | Impact of population density of left atrial remodeling in patients with atrial fibrillation | Atrial fibrillation (AF), the most common cardiac arrhythmia and a leading cause of stroke, is characterized by structural changes, or remodeling, in tissues of the left atrium (LA). Late Gadolinium-Enhancement Magnetic Resonance Imaging (LGE-MRI) can noninvasively detect remodeling in the LA, allow... | Atrial fibrillation Treatment | 2012-05 |
111 |
|
Beams, Alexander | Implications of antibiotic use for co-infections when a fitness trade-off for resistance is present | How much does indiscriminate antibiotic use promote the spread of antibiotic-resistant infections in a population? Assuming a fitness trade-off for resistance exists, it is possible for an antibiotic-vulnerable strain to outlast a resistant type within an untreated host carrying both. That means pru... | Drug resistance in microorganisms -- Mathematical models Co-infections | 2015 |
112 |
|
Owen, Cameron J. | Infrared Multiple Photon Dissociation Spectroscopy and Guided Ion Beam Tandem Mass Spectrometry: Experimental and Theoretical investigations of Transition Metal and Lanthandie Cations | Employment of Free Electron Lasers (FELs) and a Guided Ion Beam Tandem Mass Spectrometer (GIBMS) has allowed for the spectroscopic and spectrometric investigations of a variety of ionic complexes, respectively. The data presented in Chapters 2 and 3 of this thesis were obtained using two FELs locate... | Netherlands; thermochemical; Natural | 2019 |
113 |
|
Hansen, Mason | Interferon gamma inducible nampt and its role in resisting cancer cell growth | The tumor microenvironment (TME) is very complex and important due to its ability to influence the response of therapies on tumors. Immune cells infiltrate the TME and secrete inflammatory cytokines, such as interferon-gamma (IFNg), which help activate the immune system. This activation leads to an ... | | 2023 |
114 |
|
Tse, Justin | The Linear Algebra of the Last Passage Percolation Model | We study the linear algebra of the last passage percolation model. In this model, we want to find the statistics of maximal paths through a randomly weighted grid. Specifically we focus on bases of the set of path lengths made from paths. The maximum path length is a deterministic function of a much... | | 2017 |
115 |
|
Allam, Jeremy | Low-energy satellite transfer from Earth to Mars | A new type of satellite transfer that uses half the amount of fuel as conventional transfers has been discovered. This transfer, called a low-energy transfer, proved to work in 1991 when a Japanese satellite successfully went in orbit around the moon using this technique. Since then, more research h... | Space vehicles -- Dynamics -- Mathematics Space flight to Mars -- Mathematics | 2015-04 |
116 |
|
Wallace, Joshua J. | Lyman-alpha emission as a probe of galaxy environments | As a result of resonant scatterings off hydrogen atoms, Lya emission from star-forming galaxies provides a potential probe of the neutral gas environment around them. In order to determine the utility of Lya emission as a probe of gas environments we study the effects of environmental anisotropy on ... | Galaxies - Spectra | 2014-05 |
117 |
|
Zurbuchen, Rudi | Macrocyclization of glucagon-like peptide (GLP-1) by thiol-ene reaction | Macrocyclization of peptides helps maintain a stable alpha helical structure using a conformational constraining staple. One such peptide, glucagon-like peptide-1 (GLP-1), is a 37 amino acid peptide agonist for the GLP-1 receptor and has the ability to lower blood glucose levels and is responsible ... | Peptide hormones - Receptors - Research; Ring formation (Chemistry) - Research; Macrocyndization; GLP-1; Swim kinematics; Pre-pulse inhibition | 2016-05 |
118 |
|
Pearson, Cassidy | Major Urinary Protiens as a signal of genetic Quality and Infection status | The Hamilton-Zuk hypothesis suggests that susceptibility to infectious disease is so important that many physical traits, particularly secondary sexual characters, will evolve to signal genetic quality for resistance to prospective mates. We expanded upon this theory using the house mouse (Mus muscu... | | 2018 |
119 |
|
Shimko, Tyler | Mapping suppressors of premature sperm activation in C. Elegans | The sperm of the roundworm Caenorhabditis elegans move by a crawling motion, in contrast to mammalian sperm, which exhibit a swimming motion. This method of locomotion makes the sperm of C. elegans an excellent model for examining cell motility. In order to become motile, the sperm must undergo the ... | Caenorhabditis elegans -- Spermatozoa; Sperm activation | 2015-05 |
120 |
|
Tang, Anna | Mathematical model of drug resistance in ER+ breast Cancer: the role of the microenvironment | One of the main obstacles to treating cancer is its ability to evolve and resist treatment. In this project, we are primarily interested mathematically modeling how the cancer microenvironment interacts with cancer cells and affects cancer's response to therapy. We aim to develop the mathematical mo... | | 2023 |
121 |
|
Youatt, Catherine C. | Mathematics in Visual Art and Ballet | Cultures all over the globe utilize both mathematics and ballet to understand the world and to express their distinct realities. In this way, mathematics and art interact, both with math creating new visual art fields, like fractal artworks, and with art influencing mathematics, as with Renaissance ... | | 2019 |
122 |
|
Guernsey, Michael | Mclr is not solely responsible for pigmentation variation among domestic pigeons | Feather pigmentation in the domesticated rock pigeon, Columba livia, is stunningly diverse. Plumage pigmentation in this, and other, columbid (pigeon and dove) species plays an important role in mate choice and thus is a driving factor in the process of sexual selection. To study the genetic basis o... | | 2012 |
123 |
|
Franchina, Jordan Avery | Measurement of bond dissociation energies of transition metal molecules | Measuring thermochemical and kinetic properties of chemical systems has always; been a central theme of chemistry. Knowing these properties assists us in assessing; whether or not a chemical reaction is energetically feasible, efficient, and worthwhile.; Theoretical chemistry has now developed suffi... | Chemical systems; thermochemical; kinetic; modeling | 2018-04 |
124 |
|
Green, Austin | Measuring occupancy and occurrence of medium and large mammals in Red Butte Canyon Research Natural Area using motion-activated camera traps | With expanding urbanization and development, human encroachment on wilderness areas continues to increase. In Utah, much of the once pristine and untouched mountain ecosystems of the Wasatch Front have been developed for recreation and other human use, and this increasing human-wildlife interaction... | Red Butte Canyon (Salt Lake County, Utah); Wilderness area monitoring - United States; Wildlife conservation - Utah | |
125 |
|
Hayashi, Samantha | The Mechanism of Lysosome Movement During ER Stress | The Endoplasmic Reticulum (ER) is a cellular organelle responsible for the synthesis and folding of secretory proteins. When protein import into the ER exceeds the its protein folding capacity, misfolded proteins accumulate and can potentially become toxic to the cell. This situation, termed ER stre... | | 2019 |
126 |
|
Wang, Alison | Mechanistic studies of the electroanalytic reduction of CO2 TO CO: A BPY-MN(CO)3Coome model | Transition-metal electrocatalysts have previously been shown to convert carbon dioxide to carbon monoxide, which is promising for future energy schemes. Recent efforts have focused on (N^N)Mn(CO)3X complexes due to their performance and exclusion of expensive metals (X = anionic ligand, N^N = bident... | | 2023 |
127 |
|
Wang, Alison | mechanistic studies of the electrocatalytic reducation of Co2 to Co: a BPY-MN(CO)3coome model | | | 2023 |
128 |
|
Johnson, Dylan | Modular forms, Elliptic Curves, and Their Connection to Fermat's Last Theorem | Fermat's Last Theorem (FLT) states that if n is an integer greater than three, the equation xn + yn = zn has no integer solutions with xyz 6= 0. This incredible statement eluded proof for over three-hundred years: in that time, mathematicians developed numerous tools which finally proved FLT in 1995... | | 2020 |
129 |
|
Astin, Holly M. | Modulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in Zebrafish | | | 2016 |
130 |
|
Astin, M. Holly | Modulating Intestinal Liver X Receptor Activity to Alter the Development of Atherosclerosis in Zebrafish | The liver X receptors (LXRs) are important regulators of lipid and cholesterol metabolism and control diverse pathways in development, reproduction, metabolism, immunity and inflammation. Thus, LXRs have potential as therapeutic targets for diseases as diverse as lipid disorders, atherosclerosis... | Liver X receptors - Research; Zebrafish - genetics | 2016-08 |
131 |
|
Rou, Janvida | Monte-Carlo simulation of stellar intensity interferometry | Stellar intensity interferometers will allow for achieving stellar imaging with a tenth of a milli-arcsecond resolution in the optical band by taking advantage of the large light collecting area and broad range of inter-telescope distances offered by future gamma-ray Air Cherenkov Telescope (ACT) ar... | Monte Carlo simulation | 2012-05 |
132 |
|
Scholl, Wallis | Nanomite-Decorated Nanoparticles as Surface-Enhanced Spectroscopy Substrated | Surface-enhanced spectroscopy substrates utilize the localized surface plasmon resonance of nanoparticles for optical, photocatalysis, and biological and chemical sensing applications. Plasmonic anisotropic nanoparticles with sharp tips focus the electromagnetic field of the localized surface plasmo... | | 2020 |
133 |
|
Bernardo, Madeline F. | The Neural Mechanisms of Sexual Transformation in Thalassoma Bifasciatum, the Bluehead Wrasse | Thalassoma bifasciatum, the bluehead wrasse, is a protogynous sequential hermaphrodite and a commonly used model for studying environmental sex determination and adult sexual plasticity. Terminal phase (TP) male bluehead wrasses demonstrate characteristic behaviors and coloration changes when courti... | | 2020 |
134 |
|
Kroll, Tyler | Numerical floating-point code: precision-independence, base-independence, and other programming considerations | The knowledge and skills of the floating-point-literate mathematician are seldom lauded, though central to the art of translating the world of mathematics into the language of computers. This thesis highlights the importance of floatingpoint literacy through various high-utility techniques relevant ... | | 2020 |
135 |
|
Halberg, Charles | On causality in machine learning | Although the studies of causal inference and machine learning arose independently, there are emerging intersections which are proving fruitful for both fields. One of the major modern challenges in AI is to develop robust, generalizable models which can perform across a number of different tasks wit... | Developing; suggests; generalizable | 2022 |
136 |
|
Copinga, Aidan | Optimal transport and applications in partial differential equations | In the 18th century, Gaspard Monge created a mathematical framework to find the best way to describe the optimal way to rearrange the dirt dug out from the land into castle walls or other desired shapes. More recently, in the 20th century, Leonid Kantorovich explored infinite dimensional optimizatio... | | 2022 |
137 |
|
Fullmer, Alexander T. | Optimization of gamma/hadron separation under variable source intensities and energy spectra | The High Altitude Water Cherenkov (HAWC) gamma-ray observatory consists of an array of water Cherenkov tanks that can detect extensive air showers (EAS) generated by astrophysical cosmic rays and gamma rays. One of the greatest challenges in using the HAWC observatory to search for astrophysical gam... | Gamma ra sources - Observations; Cosmic rays - Observations; Gamma ray astronomy - Research | 2014-05 |
138 |
|
Cowley, Jacob | Optimization of total synthesis of indolizidine alkaloids VIA nickel catalyzed (4 + 2) cyclization utilizing silyl and stannyl alkynes | In order to expand the versatility of the synthetic route to naturally occurring indolizidine alkaloids previously developed in the Louie Group, a path was developed using a bicyclic azetidinone to produce indolizidine alkaloids such as (+)-seco-antofine. However, due to the asymmetric nature of the... | | 2021 |
139 |
|
Alexander, Amanda | Parental conflict with adult children | Parental conflict with adult children is something that is well known anecdotally, but has rarely been studied in light of other, more serious conflicts between parents and their children. However, parental conflict with adult children (adult being defined as between the ages of 18 and 25) is someth... | Adult children - Family relationships; Adult children - Psychology | 2012-05 |
140 |
|
Watson, Andre | Patterns of parasitism in a common Utah Rodent | Male-biased parasitism, where males are more commonly infected with and have higher parasite loads, is common across vertebrate taxa. Several factors could be driving this pattern. The immunocompetence handicap hypothesis suggests that higher testosterone levels in males suppress immune function whi... | | 2022 |
141 |
|
Fox, Zach | The physical effects of solvent in molecule-based magnets | Molecule-based magnets are being studied in order to expand the utility of magnets in modern devices. Advantages of molecule-based magnets include less energy intensive synthesis and greater versatility through changes to organic components of the structure. This class of materials is studied to ena... | Magnets - Experiments | 2012-05 |
142 |
|
Hales, Laurel | Physics show and tell and elementary science education | It is a well-known fact that American children are performing below their peers in international science and mathematics examinations, leading to what is commonly called the STEM education crisis. This project was created in an attempt to resolve this crisis by improving elementary school science ed... | Science - Study and teaching (Elementary) - United States | 2014-05 |
143 |
|
Radhakrishnan, Parvathi | PI3K inhibitors as potential new therapy against breast cancer progression | Receptor tyrosine kinases (RTKs) and their pleiotropic effectors play key roles in metastasis. Met and Ron are RTKs that have been shown to contribute to tumor growth and metastasis in both animal models and in patients. Recently, an alternative Ron isoform known as "short-form" Ron (sfRon) was asso... | Breast - Cancer - Treatment - Research; Protein - tyrosine kinase - inhibitors - Therapeutic use; Enzyme inhibitors - Therapeutic use. - Research; Biology - Research | 2014-05 |
144 |
|
Lee, Hani | Post-traumatic headache: an opportunity to develop new preclinical models for better understanding of pathology and treatment | Post-traumatic headache (PTH) is identified as one of the most frequent symptoms following traumatic brain injury (TBI) (Faux & Sheedy, 2008). Despite the high prevalence, there are currently no treatments which specifically target PTH. Instead of etiology-specific treatments, individuals suffering ... | | 2022 |
145 |
|
Peterson, John | Potential Therapeutic Inhibition of Epigenetic Modulator LSDI in Glioblastoma Multiforme | Glioblastoma (GBM) is the most common primary brain tumor in adults, and while advances in surgery, radiation, and standard chemotherapies have improved survival in this disease marginally over the years, the outcomes for most patients remain disappointing (Bhat, 2013). Recent studies have identifie... | | |
146 |
|
Trakhimets, Alesia | Pre-clinical trials of anti-neoplastic drugs using zebrafish with T-cell cancer | Note: To agree with NCBI nomenclature guidelines, human gene abbreviations are italicized and capitalized; human protein abbreviations are non-italicized and capitalized, and zebrafish gene abbreviations are italicized in lowercase. T lymphocytes, or T-cells, are blood cells that normally fight vira... | Antineoplastic agents - Testing; Zebra danio | 2013-04 |
147 |
|
Christensen, Kiana | Quantifying Patterns of Squamate Dental Complexity | Squamate reptiles are ideal subjects for investigating relationships between diet and dentition patterns because they exhibit wide dietary diversity and taxonomic abundance. Most previous research is qualitative and limited to a basic assessment of the influence diet has on dentition (Hotton, 1955; ... | | 2020 |
148 |
|
Tuft, Marie | Quantitative analysis of virus trafficking in a biological cell | Virus replication is a complex process that is important to understand. If a virus is to successfully infect a host cell it must travel from the cell wall to the nucleus by hijacking that cell's existing transport system of microtubules. This motion occurs as two iterated steps: passive diffusion th... | Viruses -- Reproduction -- Mathematical models; Virus trafficking | 2015-05 |
149 |
|
Dutson, Matthew J. | Reconstruction of Cosmic Ray Geometry using Cherenkov backscattering | Fluorescence detectors are often used to examine the energy spectrum and arrival directions of ultra high energy cosmic rays. An accurate reconstruction of geometry is key when determining both energy and direction. In the past, it has been necessary to build multiple fluorescence detectors to take ... | | 2017 |
150 |
|
Bingham, Kouver | Reflection groups and coxeter groups | In this paper we give a survey of the theory of Coxeter Groups and Reflection groups. This survey will give an undergraduate reader a full picture of Coxeter Group theory, and will lean slightly heavily on the side of showing examples, although the course of discussion will be based on theory. We'll... | Finite groups | 2014-07 |
151 |
|
Ellis, James H. | Refractory status epilepticus and chronic kidney disease in a large pedigree due to a variant in the mitochondrial encoded trna phenylalanine (MT-TF) gene | Mitochondrial disorders present with a wide spectrum of neurological manifestations. Clinical syndromes are described largely by phenotypic indicators. Epilepsy is a common but not universal feature. Myoclonus epilepsy with ragged red fibers (MERRF) is a common clinical syndrome that presents with e... | | 2018 |
152 |
|
Steiner, William | Regulation of protein complexes during hedgehog signal transduction | The Hedgehog (Hh) pathway is an evolutionarily conserved signaling pathway essential in embryonic development and tissue homeostasis. Several cancers can form as a result of Hh pathway dysfunction. The G protein-coupled receptor (GPCR) Smoothened (SMO) is activated upon binding of the secreted Hh pr... | | 2021 |
153 |
|
Bader, Cecily | The Response of Arabidopsis Mutant BPS1-2 on Salt Media | How would our world change if salt tolerance could be engineered in plants? The Arabidopsis mutant bps1-2 has been shown to respond differently on salt media than a nonmutated plant would. In normal conditions, the bps1-2 mutant will arrest development in the root and shoot shortly after germination... | | 2017 |
154 |
|
Excell, Katerina | The role of amyloid precursor protein in a model of alzheimer's disease | Alzheimer's disease (AD) is a devastating disorder that leads to deterioration of cognition and memory. The prevalence of AD dramatically rises with age, and is also much greater in individuals with trisomy 21 (Down syndrome, DS). Many gene products are overexpressed in DS by virtue of having three ... | | 2022 |
155 |
|
Nau, Adam | The role of heparan sulfate in maintaining stereotyped birdsong | Song learning in Zebra Finches (Taeniopygia guttata) occurs during a critical period between 30-90 post hatch days, and involves acquisition of an acoustic model and a sensorimotor period of increasingly improving imitation of this model. Young birds sing highly variable songs early during this pe... | Birdsongs - Research; Zebra finch - Research; Songbirds - Behavior; Heparan sulfate; Taeniopygia guttata; Neural circuitry | 2016-04 |
156 |
|
Russell, Nicole | The Role of Introns Within Alpha Conotoxin Genes in Cone Snails | Cone snails, of which there are more than 600 species, have attracted a lot of attention. Cone snails, found in warm tropical waters across the world, are predators and produce venoms comprising diverse toxins. These toxins, termed conotoxins, have been the subject of a great amount of research. Whi... | | 2016 |
157 |
|
Du, Wantong | The role of mRNA decay in a genetic switch | Genes can be switched on or off by regulatory proteins. For example, two genes may each synthesize a protein that downregulates the other gene, creating a repressor- repressor switch that has two stable steady states: one being when the first gene is "on" and the second gene is repressed, and the ot... | Messenger RNA - Research; Genetic regulation - Research; Genetic switch; Gene repression; Neural circuitry | 2016-04 |
158 |
|
Wang, Zhirong | The role of the autism-associated gene kirrel3 in synapse formation | Alterations in the gene Kirrel3 are repeatedly associated with intellectual disability and autism. Kirrel3 regulates synapse formation in C. elegans but the role of Kirrel3 in synapse formation in the mammalian brain is unknown. In mice, Kirrel3 is expressed in specific cell types throughout the bra... | Autism -- Genetic aspects; Synapses; Kirrel3 gene; Synapse formation | 2015-04 |
159 |
|
Wheeler, Maya | Role of WNT-Dependent Neurogenesis in Functional Recovery Following Spinal Cord Injury | In humans and other adult mammals, spinal cord injury leads to a permanent loss of motor and sensory function. The biggest obstacle to recovery is the inability of severed axons and neurons to regenerate. During embryogenesis, all vertebrates have a population of neural stem cells called radial glia... | | 2019 |
160 |
|
Kannan, Sarmishta Diraviam | The Role that Lysosomes and Autophagy play in Alveolar soft parts Sarcoma, clear cell Sarcoma and Synovial Sarcoma | Sarcomas are cancer of the connective tissue and are very deadly group of cancers. Two of the sarcoma types, alveolar soft parts sarcoma (ASPS) and clear cell sarcoma (CCS) have a unique vacuolar morphology. This unique morphology is absent in synovial sarcoma (SS). We believe that the unusual morph... | | 2017 |
161 |
|
Nguyen, Nam | Roles of Transient Receptor Potenitial Ankyrin-1 and Vanilloid-3 in Endoplasmic Reticulum stress and Cytotoxicity in Lung Epithelial Cells | Air pollution is a growing global health issue with considerable local relevance. In particular, exposure to wood smoke particulate matter (WSPM) is associated with the development and exacerbation of chronic inflammatory conditions and irreversible damage of the airways and alveoli. However, exact ... | | 2020 |
162 |
|
Christopherson, Anna | Search for the highest energy gamma rays of galactic origin using telescope array low energy fluorescence detectors | Telescope Array (TA) is the largest cosmic ray detector in the Northern Hemisphere, designed to measure cosmic rays with energies greater than 1018 eV. TA combines three fluorescence telescope sites, which are each instrumented with 12-14 telescopes, surrounding an array of 507 surface detectors tha... | | 2022 |
163 |
|
Gregersen, Dylan | Searching for extragalactic stars among candidate halo moving clusters | We seek to identify stars accreted into the Milky Way which are remnants of its merging with smaller galaxies or star clusters. In our approach, we selected stars from candidate moving clusters in the Milky Way's Halo. These stars were grouped by similar stellar characteristics: orbital energy, orbi... | Halo stars; Extragalactic origins; Milky Way | 2012-05 |
164 |
|
Duffin, Calder | Sequence Activity Relaqtionships in a Radical Sam Peptide Maturase | Ribosomally synthesized and post-translationally modified peptide Tte1186a and several point mutation variants are synthesized using solid phase peptide synthesis with FMOC amino acids. Substrate recognition and thioether linkage formation from the radical S-adenosyl methionine Tte1186 maturase is d... | | 2020 |
165 |
|
Hunter, Samuel | Signaling Role of the Hamp Domain in the Escherichia Coli Serine Chemoreceptor | The chemoreceptor Tsr enables Escherichia coli to track serine gradients in its environment. Binding of serine to the periplasmic domain propagates a signaling conformational change through other domains of the chemoreceptor molecule to modulate the activity of CheA, a kinase associated with t... | Chemoreceptors - Research | 2016-07 |
166 |
|
Olsen, Nicholas | Simple Molecular Models for Chiral Crystallization | Chiral molecules play an important role in many biological processes.1 Important chiral biomolecules include certain amino acids, sugars, DNA, RNA, and many proteins. Chiral molecules have enantiomers, mirror-image isomers that cannot be superimposed on each other. The classic analogy to enantiomers... | | 2020 |
167 |
|
Blair, Coral Dean | Snakes as a possible winter reservoir for Western equine encephalitis virus | | viruses; equine; snakes | 1964 |
168 |
|
Yang, Kevin | The Soluble (PRO) Renin Receptor does not Influence Lithium-Induced Diabetes Insipidus but does Provoke Beigning of White Adipose Tissue in Mice | Earlier we reported that the recombinant soluble (pro) renin receptor sPRR-His upregulates renal aquoporin-2 (AQP2) expression, and attenuates polyuria associated with nephrogenic diabetes insipidus (NDI) induced by vasopressin type 2 receptor (V2R) antagonism. Patients that receive lithium therapy ... | | |
169 |
|
Jensen, Trey W. | Spectral evolution in high redshift quasars from the final boss sample | We report on a study of the spectral variations in a sample of 102,150 quasars from the Baryon Oscillation Spectroscopic Survey (BOSS) of the Sloan Digital Sky Survey (SDSS-III). After mitigating selection effects and Malmquist bias over the redshift range 2:1 □ z □ 3:5, we create high... | Quasars -- Spectra; Red shift -- Observations; Baryon Oscillation Spectroscopic Survey; Sloan Digital Sky Survey; Redshift evolution | |
170 |
|
Auduong, Priscilla | Spinal muscular atrophy modeled in drosophila melanogaster | Spinal Muscular Atrophy (SMA) is the most commonly inherited cause of death in children (Park, Kariya, & Monani, 2010 for review). This disease is characterized by a loss of motor neurons which leads to muscle degeneration, paralysis, and eventual death by respiratory failure (Monani, 2005 for revie... | Spinal muscular atrophy - Research; Drosophila melanogaster - Researcher | 2012-05 |
171 |
|
Thompson, Lauren | SptlC2 Deletion in Endothelial Cells: Implications for Arterial Function | Using pharmacological and genetic approaches to inhibit whole-body ceramide biosynthesis, our laboratory showed that this sphingolipid contributes importantly to hypertension and vascular dysfunction associated with diet-induced obesity in mice. Here we tested the hypothesis that inducible, endothel... | | 2020 |
172 |
|
Thomas, J Payton | Stability of genetic oscillators with distributed delayed feedback | Genetic oscillators govern periodic phenomena in biology including circadian rhythms and are also the basis of biological clocks used in the design of synthetic genetic circuits. Models of genetic oscillators tend to neglect biological detail, however, because biological systems tend to be too compl... | | 2023 |
173 |
|
Wainer, Tobin | Star clusters in the triangulum galaxy: star cluster catalog and mass function fitting | We construct a catalog of star clusters in the Triangulum Galaxy (M33). The catalog is the result of the Local Group Cluster Search (LGCS) citizen science project through Zooniverse, where users classify images from the Hubble Space Telescope (HST). We base our star cluster catalog on the fraction o... | | 2021 |
174 |
|
Hahm, Suhyun | Stressors of varying properties induce differences in the modulation of behavior and biology | Stress induces enduring behavioral and biological consequences. Despite its pervasiveness, the biological and neural processes underlying its effects remain largely unknown. The existing literature generally examines the repercussions of stress from the aspect of a single stressor; however, stressor... | | 2022 |
175 |
|
Skedros, Gregory Athanasios | Structural and material changes in the sheep radius from newborn to adult: Functional adaptation versus developmental constraint | Bones that exhibit marked changes in structural and material characteristics during ontogeny are potentially useful for studying the mechanisms that produce functional adaptations. The diaphyseal region of the sheep radius was examined because it is relatively simply loaded in cranial-caudal bending... | Functional adaptations - Sheep; Developmental constraint - Sheep; Ontogeny | 2015-08 |
176 |
|
Farrall, Nicholas | Structural characterization of the full-length exocyst complex by transmission electron cryo-microscopy | The exocyst is a conserved octameric protein complex in eukaryotes that is essential for tethering and fusion of vesicles to the plasma membrane. Composed of eight subunits, it is essential for growth, secretion, and developmental processes and has been implicated in cell motility, autophagy, cell d... | Saccaromyces cerevisaie - Cytology; Cryomiscroscopy - Research | 2014-05 |
177 |
|
Dyer, Jamie | Studies of Spectral Variability of Quasars with Multi-Epoch Analyses | Quasars are supermassive black holes known to drive galaxy formation. They can have masses up to 109 solar masses and are the most luminous known objects in the sky, making them very important trackers of cosmic evolution. Given the large amount of research already surrounding quasar astrophysics, t... | | 2017 |
178 |
|
Bull, August John | Studying Galois Representations Using Elliptic Curves | Diophantine equations and their solution sets are prominent subjects of study in number theory. These equations are often studied modulo prime numbers or prime ideals in field extensions. Galois Theory is well-suited to study field extensions, but Galois groups are often mysterious. To remedy this, ... | | 2020 |
179 |
|
Watkins, Ryan Davis | Suppression of lymphangiogenesis using VEGF-C trap | The lymphatic system is responsible for controlling systemic fluid buildup. Lymphangiogenesis is a dynamic process involving sprouting, and maintaining new lymphatic vasculature. Vascular endothelial growth factor C (VEGF-C) is as a key growth factor that induces lymphangiogenesis by binding VEGF re... | Lymphatics - Growth; Vascular endothelial growth factors - Antagonists; Lymphangiogenesis; VEGF-C trap | 2014-05 |
180 |
|
Reece, Eric J. | Synthesis and Characterization of Proton Conducting Silica Nano-Particles for use in Polymer Electrolyte Membrane Fuel Cells | One of the fastest growing fields in scientific research is alternative energy. This has led to an investigation into the various aspects of fuel cells and their components due to their highly efficient energy conversion and low CO2 emissions. The efficiency of fuel cells is highly dependent on the ... | | 2019 |
181 |
|
Stevenson, Kincade | Synthesis and mechanistic experiments of photoelectrocyclization reactions of pyridine containing BIS-ARYL cyclohexenones | Electrocyclization reactions are commonly found in synthetic chemistry as a means to access cyclic systems and to define stereocenters. Rules for electrocyclization were developed by Woodward and Hoffman, and these rules allow chemists to predict the stereochemical outcome of potential electrocycliz... | | 2021 |
182 |
|
Cantrell, Rachel Lou-La Vonne | Synthesis of Antibiotic Scaffolds Inspired by the Tan 1057-D Biologically Active Natural Product Through the Utilization of Ullmann Copper(I) and Gold Cyclization Chemistry | As bacterial resistance to drugs continues to rise, the search for new antibiotics is of paramount importance. One key element to finding successful antibiotics is to uncover small molecules that act through novel mechanisms of action in order to decrease the risk of cross-resistance and provide ant... | | 2020 |
183 |
|
Domagala, Drue | Synthesis of protacs to inhibit toll-like receptors | The immune system is the body's defense against pathogens. Since it has to be able to withstand the fast-evolving nature of microscopic invaders, the immune system has a variety of mechanisms to recognize and destroy them. One way that pathogens are recognized is through toll-like receptor (TLR) sig... | | 2022 |
184 |
|
Randolph, Charlotte | Synthesis of VLC-Pufas relating to macular degenerative diseases | Very Long Chain Polyunsaturated Fatty Acids (VLC-PUFAs) are non-dietary fatty acids that are more than 24 carbons long and include more than one double bond. The specific compound we have focused on is 32:6 n-3: a 32-carbon molecule having 6 cis alkenes with the alkenes beginning at the omega 3 carb... | | 2022 |
185 |
|
Judd, David Paul | Telomere proteins of Drosophila melanogaster: HipHop and MSK81 | DNA molecules encoding two proteins, HipHop and MSK81, were cloned into bacteria so as to make large amounts of these proteins that bind to telomeres of Drosophila (fruit fly) chromosomes. The goal was to determine whether known DNA binding motifs are present in HipHop and MSK81. Understanding how t... | Biology | 2012-05 |
186 |
|
Roestenburg, Jessica | Testing the Perceptual Salience of Spectral Content in Zebra Finch Song | Birds actively adjust the resonance properties of the upper vocal tract during singing, which results in specific harmonic structures of song elements. To what degree upper vocal tract filtering is relevant for the perceptual salience of song is poorly understood. This research utilizes (1) a biolog... | | 2018 |
187 |
|
Aderibigbe, Justis | Trends in the usage of bidentate phosphines as ligands in nickel catalysis of hydrogenation reactions | A critically important process in catalysis is the formation of an active catalyst from the combination of a metal precursor and a ligand, as the efficacy of this reaction governs the amount of active catalyst. This review is a compacted but comprehensive review of reactions catalyzed by nickel and ... | | 2021 |
188 |
|
Austin, Maxwell Jack | Triazolinedione-Based methods for peptide cyclization and efforts toward the total synthesis of (-)-Biotin | Chapter 1 presents the development of a triazolinedione-based, tyrosine-selective method to cyclize short- to medium-sized peptides. The development of efficient conditions to prepare precursor ‘urazole' peptides is discussed. Preliminary efforts to oxidize and cyclize urazole peptides are discuss... | | 2023 |
189 |
|
Scott, Isabelle | Tropical analog to the log canonical threshold | In algebraic geometry, the log canonical threshold is a property of singularities of planar curves. While singularities have multiplicities, the log canonical threshold can be a more telling invariant. It helps to classify curves beyond what the multiplicity indicates by examining how quickly the in... | Geometry, Algebraic | 2013-04 |
190 |
|
Woodruff, Derek | Uncovering Synaptic Defects resulting from loss of the intellectual disability and autism-associated gene Kirrel3 | Neurodevelopmental disorders severely impact an individual's life. Surprisingly, the genetic and cellular cause of over half of intellectual disability cases and more than 80% of autism spectrum disorders remain undiscovered1,2. It is likely that mutations in molecules regulating synapse development... | | 2017 |
191 |
|
Walker, Kortnie | Understanding and treating diabetic retinopathy | Diabetic retinopathy is a neurovascular disease of the retina and is the leading cause of blindness in the working-age population in the United States. Complications as a result of hyperglycemia and diabetes mellitus (DM) break down the blood-retina barrier (BRB) and retinal vasculature. Current tre... | Diabetic retinopathy | 2015-05 |
192 |
|
Sageser, Emily | Understanding the radial distribution of dwarf satellite galaxies beyond the virial radii | Dark matter has been theorized to exist for over 80 years based on astronomical observations but has yet to be found in terrestrial experiments. Named for its lack of interaction with the electromagnetic field, dark matter does not absorb, reflect, or emit electromagnetic radiation making it undetec... | | 2023 |
193 |
|
Lee, Zachary | Using Drosophila to investigate p53 life-or-death decisions | The p53 tumor suppressor is a central regulator of cellular responses to DNA damage. When DNA damage cannot be repaired most cells undergo p53-dependent cell death. Thisp55-mediated apoptosis is important to eliminate cells with damaged genomes and provides an important block to the development of c... | Biology | 2013-05 |
194 |
|
McDaniel, Tyler | Utah's Pathways to Higher Education: a Critical, Quantitative Analysis | This work uses linear and nonlinear models in order to predict student success and pathways in higher education in the state of Utah. Postsecondary Grade Point Average is used as a metric for success in higher education. Pathways are identified using clustering analyses, which group observations a... | Higher education and state - Utah; Higher education and state - United States; Low-income students - United States | |
195 |
|
Kelley, Logan T. | Weighing Abell 2029: How Different Assumptions Change a Galaxy Cluster's Mass | At a given mass, the amount of galaxy clusters within some volume greatly depends on certain cosmological parameters. Examples of such parameters are: how much total mass there is (nm), the equation of state parameter of dark energy (w), and the scale of fluctuations (o8). These quantities can be me... | | 2020 |
196 |
|
Wilson, Alexis | West Antarctica as a Natural Laboratory for Cloud Microphysics | Clouds contribute to energy regulation in the global climate system. Remote and unaffected by local pollution sources, Antarctica offers a unique laboratory to study clouds and their influence on the surface energy budget. The study of these clouds is particularly interesting as global temperatures ... | | 2017 |
197 |
|
Checketts, Cynthia | Why white mice? improving biological literacy through animal history | Throughout the undergraduate experience, biology students are introduced to hundreds of experiments, theories, and principles, many of which are rooted in animal experimentation. However, in required and information-heavy biology courses, the erasure of animals from the scientific story-which repres... | | 2021 |