UScholar Works
 
Filters: Format Medium: "application/pdf" Collection: "ir_uspace" Subject: "Zyxin"
1 - 25 of 18
Number of results to display per page
CreatorTitleDescriptionSubjectDate
1 Beckerle, Mary C.Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and AktThis study delineates a mechanism for antiapoptotic signaling initiated by atrial natriuretic peptide (ANP) stimulation leading to elevation of cGMP levels and subsequent nuclear accumulation of Akt kinase associated with zyxin, a cytoskeletal LIM-domain protein. Nuclear targeting of zyxin induces r...Zyxin; Akt; Cyclic guanosine monophosphate2005
2 Beckerle, Mary C.Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeletonLIM domains are present in a number of proteins including transcription factors, a protooncogene product, and the adhesion plaque protein zyxin. The LIM domain exhibits a characteristic arrangement of cysteine and histidine residues and represents a novel zinc binding sequence (Michelsen et al., ...Zyxin; Cysteine-rich proteins; cCRP; Actin; LIM domains1994
3 Beckerle, Mary C.Characterization of the interaction between zyxin and members of the Ena/Vasodilator-stimulated Phosphoprotein family of proteinsZyxin contains a proline-rich N-terminal domain that is similar to the C-terminal domain in the ActA protein of the bacteria, Listeria monocytogenes. We screened the entire amino acid sequence of human zyxin for Menainteracting peptides and found that, as with ActA, proline-rich sequences were the s...Zyxin; Actin; Listeria monocytogenes; Proline-rich repeats; Cell spreading2000
4 Beckerle, Mary C.Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expressionMembers of the cysteine-rich protein (CRP) family are evolutionarily conserved proteins that have been implicated in the processes of cell proliferation and differentiation. In particular, one CRP family member has been shown to be an essential regulator of cardiac and skeletal muscle development.LIM domains; Chicken fibroblasts; Zyxin; Actinin; Protein expression; Cysteine-rich proteins1997
5 Beckerle, Mary C.; Hoffman, Laura M.; Yoshigi, MasaakiGenetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodelingFocal adhesions are specialized regions of the cell surface where integrin receptors and associated proteins link the extracellular matrix to the actin cytoskeleton. To define the cellular role of the focal adhesion protein zyxin, we characterized the phenotype of fibroblasts in which the zyxin gene...Zyxin; Actin; Mena/VASP2006
6 Beckerle, Mary C.Interaction between zyxin and α-actininZyxin is an 82-kD protein first identified as a component of adhesion plaques and the termini of stress fibers near where they associate with the cytoplasmic face of the adhesive membrane. We report here that zyxin interacts with the actin cross-linking protein α-actinin.Zyxin; Actinin; Actin1992
7 Beckerle, Mary C.; Yoshigi, Masaaki; Hoffman, Laura M.; Yost, H. JosephMechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcementOrgans and tissues adapt to acute or chronic mechanical stress by remodeling their actin cytoskeletons. Cells that are stimulated by cyclic stretch or shear stress in vitro undergo bimodal cytoskeletal responses that include rapid reinforcement and gradual reorientation of actin stress fibers; howev...Zyxin; Actin2005
8 Beckerle, Mary C.Members of the zyxin family of LIM proteins interact with members of the p130cas family of signal transducersIntegrin binding to extracellular matrix proteins induces formation of signaling complexes at focal adhesions. Zyxin co-localizes with integrins at sites of cellsubstratum adhesion and is postulated to serve as a docking site for the assembly of multimeric protein complexes involved in regulating ce...Zyxin; Actin; LIM domains; Trip6; Focal adhesions2002
9 Beckerle, Mary C.Molecular characterization of human zyxinZyxin is a component of adhesion plaques that has been suggested to perform regulatory functions at these specialized regions of the plasma membrane. Here we describe the isolation and characterization of cDNAs encoding human and mouse zyxin.Zyxin; Proline; LIM domains1996
10 Beckerle, Mary C.Molecular dissection of a LIM domainLIM domains are novel sequence elements that are found in more than 60 gene products, many of which function as key regulators of developmental pathways. The LIM domain, characterized by the cysteine-rich consensus CX2CX16_23HX2CX2CX2CX16_21CX2-3(C/H/ D), is a specific metal-binding structure tha...LIM domains; Metal-binding; Zyxin; Cysteine-rich proteins1997
11 Beckerle, Mary C.Molecular dissection of zyxin function reveals its involvement in cell motilitySpatially controlled actin filament assembly is critical for numerous processes, including the vectorial cell migration required for wound healing, cell-mediated immunity, and embryogenesis. One protein implicated in the regulation of actin assembly is zyxin, a protein concentrated at sites where t...Zyxin; Actinin; Ena/VASP1999
12 Beckerle, Mary C.Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleusIntegrin-dependent cell adhesion to specific extracellular matrix molecules has been demonstrated to trigger dramatic changes in gene expression that can affect cell fate. However, little is understood about the molecular mechanism by which events at sites of cell-substratum adhesion are communicate...Zyxin; Cytosol; Nuclear export signal1997
13 Beckerle, Mary C.Opposing roles of zyxin/LPP ACTA repeats and the LIM domain region in cell-cell adhesionCadherins mediate cell-cell adhesion by linking cell junctions to actin networks. Although several actin regulatory systems have been implicated in cell-cell adhesion, it remains unclear how such systems drive cadherin-actin network formation and how they are regulated to coincide with initiation o...Zyxin; Actin; Cadherin; LIM domains; VASP2006
14 Beckerle, Mary C.Purification and characterization of zyxin, an 82,000-Dalton component of adherens junctionsWe describe here the purification and characterization of a recently identified adherens junction protein that has an apparent molecular mass of 82 kDa on sodium dodecyl sulfate-polyacrylamide gels (Beckerle, M. C. (1986) J. Cell Biol. 103, 1679-1687). The 82-kDa protein was isolated from avian smoo...Zyxin1992
15 Beckerle, Mary C.; Hoffman, Laura M.Supervillin modulation of focal adhesions involving TRIP6/ZRP-1Cell-substrate contacts, called focal adhesions (FAs), are dynamic in rapidly moving cells. We show that supervillin (SV)-a peripheral membrane protein that binds myosin II and F-actin in such cells-negatively regulates stress fibers, FAs, and cell-substrate adhesion. The major FA regulatory sequenc...Supervillin; Focal adhesions; Zyxin; LIM domains; TRIP62006
16 Beckerle, Mary C.; Hoffman, Laura M.Targeted disruption of the murine zyxin geneZyxin is an evolutionarily conserved protein that is concentrated at sites of cell adhesion, where it associates with members of the Enabled (Ena)/vasodilator-stimulated phosphoprotein (VASP) family of cytoskeletal regulators and is postulated to play a role in cytoskeletal dynamics and signaling.Zyxin2003
17 Beckerle, Mary C.Targeting of zyxin to sites of actin membrane interaction and to the nucleusThe localization of proteins to particular intracellular compartments often regulates their functions. Zyxin is a LIM protein found prominently at sites of cell adhesion, faintly in leading lamellipodia, and transiently in cell nuclei. Here we have performed a domain analysis to identify regions in ...Zyxin; Actin; LIM domains; Focal adhesions; Lamellipodia; Cytoskeletal architecture2001
18 Beckerle, Mary C.Zyxin and cCRP: Two interactive LIM domain proteins associated with the cytoskeletonInteraction with extracellular matrix can trigger a variety of responses by cells including changes in specific gene expression and cell differentiation. The mechanism by which cell surface events are coupled to the transcriptional machinery is not understood, however, proteins localized at sites o...Zyxin; Cysteine-rich proteins; cCRP; LIM domain1992
1 - 25 of 18