Creator | Title | Description | Subject | Date | ||
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1 |
![]() | Beckerle, Mary C. | Activation-dependent redistribution of the adhesion plaque protein, talin, in intact human platelets | Talin is a high molecular weight protein localized at adhesion plaques in fibroblasts. It binds vinculin and integrin and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton. | Talin | 1989 |
2 |
![]() | Beckerle, Mary C. | Adhesion plaque protein, talin, is phosphorylated in vivo in chicken embryo fibroblasts exposed to the tumor-promoting phorbol ester | Talin is a high molecular weight phosphoprotein that is localized at adhesion plaques. We have found that talin phosphorylation increases 3.0-fold upon exposure of chicken embryo fibroblasts to the tumor-promoting phorbol ester, phorbol 12-myristate 13-acetate. | Talin; Vinculin; Chicken embryo fibroblasts | 1990 |
3 |
![]() | Beckerle, Mary C. | Kindler syndrome protein is regulated by Transforming Growth Factor-β and involved in integrin-mediated adhesion | Transforming growth factor-β1 (TGF-β1) contributes to tumor invasion and cancer progression by increasing the motility of tumor cells. To identify genes involved in TGF-β-mediated cell migration, the transcriptional profiles of human mammary epithelial cells (HMEC) treated with TGF-β were compar... | Kindler syndrome; Kindlerin; Talin; Focal adhesions; FERM domain | 2004 |