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1 Olivera, Baldomero M.; Gray, William Robert; McIntosh, J. MichaelNeuronal calcium channel inhibitors: synthesis of ω-conotoxin GVIA and effects on 45Ca-uptake by synaptosomesWe previously described a 27-amino acid peptide neurotoxin from the venom of Conus geographus, wconotoxin GVIA, which inhibits neuronal voltage-activated calcium channels. In this paper we describe the total synthesis of ω-conotoxin GVIA and demonstrate that it efficiently blocks voltage-activat...Neuronal calcium; Calcium channels; Channel inhibitors; [omega]-conotoxin GVIA1987
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