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| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
 | Capecchi, Mario R.; Thomas, Kirk R. | High frequency targeting of genes to specific sites in the mammalian genome | We corrected a defective gene residing in the chromosome of a mammalian cell by injecting into the nucleus copies of the same gene carrying a different mutation. We determined how the number, the arrangement, and the chromosomal position of the integrated gene, as well as the number of injected mo... | Homologous recombination; Mutant genes; Mammalian genome | 1986 |
| 2 |
 | Capecchi, Mario R.; Thomas, Kirk R. | Swaying is a mutant allele of the proto-oncogene Wnt-1 | Mice homozygous for the recessive mutation swaying (SW) are characterized by ataxia and hypertonia, attributed to the malformation of anterior regions of the cerebellum. We show that SW is a deletion of a single base pair from the proto-oncogene Wnf-1. The deletion is predicted to cause premature t... | Swaying allele; protooncogene Wnt-1; Mutant genes; Mutant alleles | 1991 |
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