UScholar Works
 
Filters: Format Medium: "application/pdf" Collection: "ir_uspace" Subject: "Actin"
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CreatorTitleDescriptionSubjectDate
1 Beckerle, Mary C.ALP-enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegansMutations that affect the Z-disk-associated ALP-Enigma proteins have been linked to human muscular and cardiac diseases. Despite their clear physiological significance for human health, the mechanism of action of ALP-Enigma proteins is largely unknown. In Caenorhabditis elegans, the ALP-Enigma prot...Actin; Caenorhabditis elegans; Contractility; alp-1 mutants; Z-disks; Kettin2009
2 Beckerle, Mary C.Analysis of the roles of microtubules and actin in erythrophore intracellular motilityThe Holocentrus erythrophore, a red pigment cell, represents a model system for the study of organized intracellular transport. We have investigated the possibility that microtubules and actin are integral components of the pigment translocating motility machine.Actin; Actomyosin; Erythrophore; Pigment1983
3 Beckerle, Mary C.Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeletonLIM domains are present in a number of proteins including transcription factors, a protooncogene product, and the adhesion plaque protein zyxin. The LIM domain exhibits a characteristic arrangement of cysteine and histidine residues and represents a novel zinc binding sequence (Michelsen et al., ...Zyxin; Cysteine-rich proteins; cCRP; Actin; LIM domains1994
4 Beckerle, Mary C.Characterization of the interaction between zyxin and members of the Ena/Vasodilator-stimulated Phosphoprotein family of proteinsZyxin contains a proline-rich N-terminal domain that is similar to the C-terminal domain in the ActA protein of the bacteria, Listeria monocytogenes. We screened the entire amino acid sequence of human zyxin for Menainteracting peptides and found that, as with ActA, proline-rich sequences were the s...Zyxin; Actin; Listeria monocytogenes; Proline-rich repeats; Cell spreading2000
5 Beckerle, Mary C.Cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiationIn this report, an antisense RNA strategy has allowed us to show that disruption of ALP expression affects the expression of the muscle transcription factors myogenin and MyoD, resulting in the inhibition of muscle differentiation. Introduction of a MyoD expression construct into ALP-antisense cells...Skeletal muscle; PDZ-LIM protein; Actin; Actinin-associated LIM proteins; Serum response factor; Cytoskeletal architecture2007
6 Beckerle, Mary C.Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated plateletsActivation of blood platelets triggers a series of responses leading to the formation and retraction of blood clots. Among these responses is the establishment of integrin-mediated transmembrane connections between extracellular matrix components and the actin cytoskeleton of the platelet.Actin; GPIIb-IIIa1993
7 Beckerle, Mary C.; Hoffman, Laura M.; Yoshigi, MasaakiGenetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodelingFocal adhesions are specialized regions of the cell surface where integrin receptors and associated proteins link the extracellular matrix to the actin cytoskeleton. To define the cellular role of the focal adhesion protein zyxin, we characterized the phenotype of fibroblasts in which the zyxin gene...Zyxin; Actin; Mena/VASP2006
8 Beckerle, Mary C.Identification of a new protein localized at sites of cell-substrate adhesionA new protein found at sites of cellsubstrate adhesion has been identified by analysis of a nonimmune rabbit serum. By indirect immunofluorescence this serum stains focal contacts (adhesion plaques) and the associated termini of actin filament bundles in cultured chicken cells.Actin; Nonimmune rabbit serum; Polypeptide1986
9 Beckerle, Mary C.Interaction between zyxin and α-actininZyxin is an 82-kD protein first identified as a component of adhesion plaques and the termini of stress fibers near where they associate with the cytoplasmic face of the adhesive membrane. We report here that zyxin interacts with the actin cross-linking protein α-actinin.Zyxin; Actinin; Actin1992
10 Beckerle, Mary C.; Yoshigi, Masaaki; Hoffman, Laura M.; Yost, H. JosephMechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcementOrgans and tissues adapt to acute or chronic mechanical stress by remodeling their actin cytoskeletons. Cells that are stimulated by cyclic stretch or shear stress in vitro undergo bimodal cytoskeletal responses that include rapid reinforcement and gradual reorientation of actin stress fibers; howev...Zyxin; Actin2005
11 Beckerle, Mary C.Members of the zyxin family of LIM proteins interact with members of the p130cas family of signal transducersIntegrin binding to extracellular matrix proteins induces formation of signaling complexes at focal adhesions. Zyxin co-localizes with integrins at sites of cellsubstratum adhesion and is postulated to serve as a docking site for the assembly of multimeric protein complexes involved in regulating ce...Zyxin; Actin; LIM domains; Trip6; Focal adhesions2002
12 Beckerle, Mary C.Opposing roles of zyxin/LPP ACTA repeats and the LIM domain region in cell-cell adhesionCadherins mediate cell-cell adhesion by linking cell junctions to actin networks. Although several actin regulatory systems have been implicated in cell-cell adhesion, it remains unclear how such systems drive cadherin-actin network formation and how they are regulated to coincide with initiation o...Zyxin; Actin; Cadherin; LIM domains; VASP2006
13 Beckerle, Mary C.Purification and characterization of an α-actinin-binding PDZ-LIM protein that is up-regulated during muscle differentiationα-Actinin is required for the organization and function of the contractile machinery of muscle. In order to understand more precisely the molecular mechanisms by which α-actinin might contribute to the formation and maintenance of the contractile apparatus within muscle cells, we performed a scree...LIM domains; Z-disc; Actin; Actinin-associated LIM proteins; PDZ-LIM protein1999
14 Beckerle, Mary C.Targeting of zyxin to sites of actin membrane interaction and to the nucleusThe localization of proteins to particular intracellular compartments often regulates their functions. Zyxin is a LIM protein found prominently at sites of cell adhesion, faintly in leading lamellipodia, and transiently in cell nuclei. Here we have performed a domain analysis to identify regions in ...Zyxin; Actin; LIM domains; Focal adhesions; Lamellipodia; Cytoskeletal architecture2001
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