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 | Olivera, Baldomero M.; Gray, William Robert; McIntosh, J. Michael | Neuronal calcium channel inhibitors: synthesis of ω-conotoxin GVIA and effects on 45Ca-uptake by synaptosomes | We previously described a 27-amino acid peptide neurotoxin from the venom of Conus geographus, wconotoxin GVIA, which inhibits neuronal voltage-activated calcium channels. In this paper we describe the total synthesis of ω-conotoxin GVIA and demonstrate that it efficiently blocks voltage-activat... | Neuronal calcium; Calcium channels; Channel inhibitors; [omega]-conotoxin GVIA | 1987 |