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1 Cannon, Grant W.Clinical and laboratory outcomes during the treatment of rheumatoid arthritis with methotrexate.Ten clinical and three laboratory outcomes were evaluated in 86 patients completing a double-blind placebo-controlled trial of methotrexate in rheumatoid arthritis. The improvement in all measured outcomes was statistically significantly better in patients receiving methotrexate than in patients rec...C-Reactive Protein; Fluorescent Antibody Technique; Latex Fixation Tests; Randomized Controlled Trials1990-02-01
2 Cannon, Grant W.; Clayton, Frederic; Griffiths, Marie M.Passive transfer of adjuvant-induced arthritis into irradiated DA recipient rats.Adjuvant-induced arthritis (AIA) can be passively transferred in Dark Agouti (DA) rats by spleen and lymph node cells after culture with Concanavalin A (Con A). A model not requiring in vitro Con A expansion and activation would be important in investigations of anti-rheumatic drugs in AIA. A new mo...Cell Transplantation; Rats, Inbred Strains1993
3 Griffiths, Marie M.; Cole Barry C.; Cannon, Grant W.T-cell receptors and collagen induced arthritis in H-2r mice.Mouse strains B10, B10.RIII, RIIIS/J and the F1 and backcross progeny arising from them were tested for susceptibility to porcine type II collagen-induced arthritis (PII-CIA). The clinically severe arthritis of rapid onset that is characteristic of PII-immunized B10.RIII mice developed predominantly...Genotype; Mice, Inbred C57BL; Sex Characteristics; T-Lymphocytes1993
4 Griffiths, Marie M.; Sawitzke, Allen D.; Cannon, Grant W.Exacerbation of collagen-induced arthritis in rats by rat cytomegalovirus is antigen-specific.Collagen-Induced Arthritis (CIA) is an experimentally induced and genetically controlled animal model of chronic joint inflammation. In rats, there are informative strain differences in susceptibility to CIA. DA rats (RT1avl) develop severe CIA after immunization with bovine (BII), chick (CII), or h...Autoimmunity; Flow Cytometry; Rats, Inbred Strains; Sex Factors1994
5 Cannon, Grant W.; Clegg, Daniel O.; Moncur, Carolee; Willardson, DebraInter-observer reliability of the Spondylitis Functional Index Instrument for assessing spondylarthropathies.OBJECTIVE: To study the Spondylitis Functional Index (SFI) by having two physical therapists observe patients with spondylitis perform various tasks listed on the instrument. The physical therapists' observations were compared with each other and with the self-reported abilities of the patients. ...Spondylitis Functional Index (SFI); physical therapists; sulfasalazine1996-06
6 Hunt, Steven C.; Adams, Ted; Hopkins, Paul N.; Hunt, Steven C.ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetesAdipose triglyceride lipase (ATGL) was recently described to predominantly perform the initial step in triglyceride hydrolysis and therefore seems to play a pivotal role in the lipolytic catabolism of stored fat in adipose tissue. In the first study investigating genetic variations within the ATGL g...Diabete, Type 2; ATGL; Fat; Triglycerides2006
7 LaStayo, Paul C.Resistance exercise with older fallers: Its impact on intermuscular adipose tissueObjective. Greater skeletal muscle fat infiltration occurs with age and contributes to numerous negative health outcomes. The primary purpose was to determine whether intermuscular adipose tissue (IMAT) can be influenced by an exercise intervention and if a greater reduction in IMAT occurs with ecce...2014-01-01
8 LaStayo, Paul C.Muscle force and movement variability before and after total knee arthroplasty: a reviewVariability in muscle force output and movement variability are important aspects of identifying individuals with mobility deficits, central nervous system impairments, and future risk of falling. This has been investigated in elderly healthy and impaired adults, as well as in adults with osteoarthr...2014-01-01
9 LaStayo, Paul C.Intermuscular fat: a review of the consequences and causesMuscle's structural composition is an important factor underlying muscle strength and physical function in older adults. There is an increasing amount of research to support the clear disassociation between the loss of muscle lean tissue mass and strength with aging. This disassociation implies that...2014-01-01
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