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1 Varner, Michael W.Abnormal pregnancy sonogram: selective indication for fetal karyotype.The inability to make a definitive diagnosis in the fetus with a sonographically identified abnormality often results in parental and physician uncertainty. An antenatal chromosome evaluation could resolve this uncertainty. Forty-one fetuses with an abnormal ultrasound examination were tested for ka...Chromosome Disorders; Pregnancy; Karyotyping; Abnormalities; Amniocentesis1987-01
2 Coffin, Cheryl M.; Capecchi, Mario R.Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.Alveolar rhabdomyosarcoma is an aggressive childhood muscle cancer for which outcomes are poor when the disease is advanced. Although well-developed mouse models exist for embryonal and pleomorphic rhabdomyosarcomas, neither a spontaneous nor a transgenic mouse model of alveolar rhabdomyosarcoma has...Cell Differentiation; Forkhead Transcription Factors; Myogenic Regulatory Factors2004-11-01
3 Varner, Michael W.Association of obesity with pulmonary and nonpulmonary complications of pregnancy in asthmatic women.OBJECTIVE: To evaluate whether maternal obesity is associated with pulmonary and nonpulmonary pregnancy complications in asthmatic women. METHODS: This is a secondary analysis of the prospective cohort Asthma During Pregnancy Study. Asthma patients were classified as having either mild or moderate t...Asthma; Body Mass Index; Pregnancy Outcome; Lung Diseases2006-07
4 Varner, Michael W.Asthma during pregnancyOBJECTIVE: To determine neonatal and maternal outcomes stratified by asthma severity during pregnancy by using the 1993 National Asthma Education Program Working Group on Asthma and Pregnancy definitions of asthma severity. The primary hypothesis was that moderate or severe asthmatics would have an ...Asthma; Infant, Newborn; Pregnancy Outcomes2004-01
5 Hobson-Rohrer, Wendy L.Benefits and Barriers of Interprofessional Education Beyond the ClassroomMedical schools need to include interprofessional education (IPE) in their curricula not only to meet accreditation standards but to optimize students' readiness to practice in today's team-based heathcare environment. This is most often accomplished in classroom settings.Interprofessional Education; Team-Based Patient Cre; Collaboration2020
6 Varner, Michael W.Blood transfusion and cesarean delivery.OBJECTIVE: To evaluate risks for intraoperative or postoperative packed red blood cell transfusion in women who underwent cesarean delivery. METHODS: This was a 19-university prospective observational study. All primary cesarean deliveries from January 1, 1999, to December 31, 2000, and all repeat c...Blood Transfusion; Postpartum Hemorrhage; Pregnancy Complications; Anemia2006-10
7 Varner, Michael W.Cerebral vasculopathies masquerading as eclampsia.Obstetricians know that preeclampsia-eclampsia is a syndrome and is a final common pathway for multiple causes. It is also possible that other conditions, not always directly related to pregnancy, can mimic preeclampsia-eclampsia. One such entity is cerebral vasculopathy, an entity characterized b...Cerebrovascular Disorders; Eclampsia; Puerperal Disorders2006-02
8 Buchi, Karen F.; Varner, Michael W.Changing prevalence of prenatal substance abuse in Utah.OBJECTIVE: To estimate the current prevalence of prenatal exposure to methamphetamines and other drugs of abuse among infants born in Utah and compare the results with those of a maternal substance abuse prevalence study performed in 1991 in the same geographic area. METHODS: Thirteen well baby nurs...Street Drugs; Prenatal Care; Maternal Exposure; Infant, Newborn2003-06-12
9 Varner, Michael W.Complications of anesthesia for cesarean delivery.OBJECTIVE: To quantify anesthesia-related complications associated with cesarean delivery in a well-described, prospectively ascertained cohort from multiple university-based hospitals in the United States and to evaluate whether certain factors would identify women at increased risk for a failed re...Cesarean Section; Complications of Anesthesia2005-08
10 Varner, Michael W.; Digre, Kathleen B.Cranial magnetic resonance imaging in eclampsia.Although the precise neuropathologic basis for eclamptic convulsions remains unclear, intracranial hemorrhage is frequently associated with fatal cases. Magnetic resonance imaging (MRI) is a recently developed neuroimaging technique that appears superior to other processes for defining intracranial ...Eclampsia; Brain Edema; Cranial Magnetic Resonance Imaging1987-09
11 Varner, Michael W.Decidual, amniotic fluid, maternal and fetal prolactin in normal and abnormal pregnancies.In the present studies, the content and the in vitro production of prolactin by decidua as well as the concentrations of prolactin in amniotic fluid, maternal and fetal serum in normal term pregnancies, induced abortions at various gestational ages, and in pregnancies complicated by diabetes mellitu...Decidual; Amniotic Fluid; Prolactin; Pregnancy Complications1984-03
12 Varner, Michael W.Decision-to-incision times and maternal and infant outcomes.OBJECTIVE: To measure decision-to-incision intervals and related maternal and neonatal outcomes in a cohort of women undergoing emergency cesarean deliveries at multiple university-based hospitals comprising the National Institute of Child Health and Human Development Maternal-Fetal Medicine Units N...Cesarean Section; Fetal Distress; Outcome Assessment; Fetal Distress2006-07
13 Varner, Michael W.Diagnosis of maternal cystic fibrosis during pregnancy.The third and fourth cases of maternal cystic fibrosis diagnosed during pregnancy are presented. Quantitative pilocarpine iontophoresis (sweat chlorides) must be performed to establish the diagnosis. Other important findings include recurrent or persistent respiratory symptoms, chest x-ray abnormali...Pregnancy; Cystic Fibrosis; Chlorides; Respiratory Insufficiency1983-03
14 Florsheim, Paul W.; Ngu, LeDifferential outcomes among adolescent fathers: understanding fatherhood as a transformative processIn response to the rising numbers of mother headed households, there is a great debate about whether to encourage young unwed parents to marry. Policies designed to pursue and/or punish fathers who do not meet their legal and financial responsibilities and to promote marriage, carte blanche, are ref...Parenting; Gender; Matrimony2003-10-18
15 Varner, Michael W.Does progesterone treatment influence risk factors for recurrent preterm delivery?OBJECTIVE: To examine how demographic and pregnancy characteristics can affect the risk of recurrent preterm delivery and the how the effectiveness of progesterone treatment for prevention alters these relationships. METHODS: This was a secondary analysis of a randomized trial of 17alpha-hydroxyprog...Preterm Delivery; Progesterone Treatment; Pregnancy; Risk Factors2005-09
16 Varner, Michael W.Elevated second-trimester maternal serum hCG: a marker of inadequate angiogenesis.OBJECTIVE: To measure angiogenin, a potent inducer of neovascularization and interleukin-6, as an indicator of acute inflammation, in second-trimester amniotic fluid of patients with elevated maternal serum hCG. METHODS: In this case-control study, 20 patients with elevated maternal serum hCG (at le...Angiogenesis Inducing Agents; Interleukin-6; Pregnancy Complications; hCG1998-04
17 Varner, Michael W.Elevations of amniotic fluid macrophage inflammatory protein-1 alpha concentrations in women during term and preterm labor.OBJECTIVE: To determine whether elevated concentrations of macrophage inflammatory protein-1 alpha (MIP-1 alpha) in amniotic fluid (AF) are related to term and preterm labor. METHODS: Amniotic fluid was obtained from women from five different clinical situations: 1) term cesarean delivery, no labor ...Amniotic Fluid; Macrophage Inflammatory Protein-1; Obstetric Labor, Premature1996-01
18 Varner, Michael W.Endotoxin enhancement as a possible etiology of early-onset group B beta-hemolytic streptococcal sepsis in the newborn.Group B streptococcal cells, either viable or heat-killed, contain a substance that induced fever in rabbits with maximal responses occurring four hours after intravenous injection. In contrast, supernatant fluids failed to induce significant fever. Group B streptococcal cells also enhanced host sus...Newborns; Endotoxins; Group B Beta-Hemolytic Streptococcal Sepsis1983-05
19 Varner, Michael W.Episiotomy: techniques and indications.In current obstetric practice episiotomy is generally taken to refer to an incision of the perineum and vagina to facilitate vaginal delivery. While the most precise definition of this incision is perineotomy, episiotomy is the generally employed terminology and thus is used in this article. The e...Episiotomy; Adverse Effects; Perineotomy1986-06
20 Varner, Michael W.Fetal injury associated with cesarean delivery.OBJECTIVE: To describe the incidence and type of fetal injury identified in women undergoing cesarean delivery. METHODS: Between January 1, 1999, and December 31, 2000, a prospective cohort study of all cesarean deliveries was conducted at 13 university centers. Information regarding maternal and in...Birth Injuries; Cesarean Section; Adverse Effects2006-10
21 Moon, Ann M.; Capecchi, Mario R.Fgf8 is required for outgrowth and patterning of the limbs.The expression pattern and activity of fibroblast growth factor-8 (FGF8) in experimental assays indicate that it has important roles in limb development, but early embryonic lethality resulting from mutation of Fgf8 in the germ line of mice has prevented direct assessment of these roles. Here we rep...Animals; Body Patterning; Bone Morphogenetic Proteins; Ectoderm2000-12-26
22 Varner, Michael W.hPL: physiologic and pathophysiologic observations.Serum human placental lactogen (hPL) levels were studied in 806 women in late pregnancy. The hPL levels were positively correlated with birth weight but were unrelated to maternal age, parity, socioeconomic status, or the sex of the newborn. The hPL levels peaked at 37 weeks' gestation and then decl...hPL; Pregnancy Complications; Pregnancy, Multiple; Infant, Newborn; Birth Weight1979-08
23 Varner, Michael W.Human placental lactogen and other placental proteins as indicators of fetal well-being.The purpose of this article will be to review the role of hPL and the newer hormones as indicators of fetal well-being.Human Placental Lactogen; Pregnancy Proteins; Indicators of Fetal Well-Being1982-12
24 Varner, Michael W.Human placental lactogen: a predictor of perinatal outcome?Serial human placental lactogen (hPL) determinations were performed on 806 women with normal and abnormal pregnancies late in the pregnancy. These results were not reported to the clinicians involved. For the study population as a whole, low hPL levels did not effectively predict those adverse perin...Infant, Newborn; Placental Lactogen; Pregnancy; Prenatal Diagnosis1979-08
25 Varner, Michael W.Intergenerational predisposition to operative delivery.OBJECTIVE: To determine the risk of cesarean delivery for women who themselves were born via operative delivery. METHODS: A linked data base was constructed between the birth certificates of individuals born in Utah during 1947-1957 (parental cohort) and who subsequently became a parent of offspring...Cesarean Section; Cohort Studies; Delivery, Obstetric; Obstetric Labor Complications1996-06
26 Kriesel, John D.; Gooch, Willis M.; Pavia, Andrew T.Invasive sinonasal disease due to Scopulariopsis candida: case report and review of scopulariopsosis.Sinonasal infection with fungi of the order Mucorales--termed mucormycosis or zygomycosis--is sometimes seen in immunosuppressed patients, including those with diabetic ketoacidosis and malignancy. We describe a case of invasive sinonasal infection with Scopulariopsis candida (not among the Mucorale...Granulocyte Colony-Stimulating Factor; Itraconazole; Maxillary Sinus1994
27 Varner, Michael W.Maternal mortality in Utah.OBJECTIVE: To determine trends in maternal deaths in Utah, identify opportunities for preventive intervention, and analyze the mechanism of reporting maternal deaths. METHODS: A retrospective review was performed of maternal death certificates and medical records in Utah from January 1, 1982, throug...Maternal Death; Utah; Pregnancy; Trauma; Pulmonary Emboliam; Maternal Cardiac Disease1998-02
28 Varner, Michael W.Multiple gestation: time interval between delivery of the first and second twins.A clinical investigation was undertaken to challenge the commonly accepted view that the interval between the birth of the first and second twins should be preferably within 15 minutes and certainly no more than 30 minutes. During 1981 and 1982, 115 patients with live-born twins at 34 or more weeks'...Twins; Time Interval Between Births; Fetal Monitoring1984-04
29 Gibbs, Katie Bernice; Frazer, John K.otg, a heritable T-cell malignancy in zebrafish that exhibits apoptosis resistanceOtg (oscar the grouch), a line of zebrafish identified with a T cell malignancy pseudoposition, has a recessive inheritance pattern with approximately 50% penetrance in presumed homozygotes (m/m). After breeding otg with a wild-type lck::eGFP fish to create obligate heterozygotes (+/m), and then in...otg; Oscar the grouch zebrafish; Apoptosis resistance; T cell malignancy; Pseudoposition; Trapeze Interactive poster2010-03-15
30 Hansen, Mark S.; Coffin, Cheryl M.; Capecchi, Mario R.Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.To investigate the role of the translocation-associated gene Pax3:Fkhr in alveolar rhabdomyosarcomas, we generated a Cre-mediated conditional knock-in of Pax3:Fkhr into the mouse Pax3 locus. Exploring embryonic tumor cell origins, we replaced a Pax3 allele with Pax3:Fkhr throughout its expression do...Neuroprogenitor; Embryogenesis2004-11-01
31 Varner, Michael W.Physiologic changes in pregnancy: surgical implications.Pregnancy has measurable effects on essentially every organ system in a woman's body. An understanding of these changes is vital for determining what is normal or abnormal in a pregnant woman. These changes frequently alter symptoms and signs of surgical diseases during pregnancy. In addition, ma...Pregnancy; Physiologic Changes; Surgical Implications1994-06
32 Varner, Michael W.; Cannon, Cynthia; Ward, RobertPopulation-based study of congenital diaphragmatic hernia in Utah: 1988-1994.OBJECTIVE: To define the natural history of congenital diaphragmatic hernia and to determine the potential impact of fetal therapy. METHODS: This retrospective case series consisted of all fetuses and neonates with congenital diaphragmatic hernia born between 1988 and 1994 in the state of Utah that ...Hernia, Diaphragmatic; Fetal Diseases; Prenatal Diagnosis; Utah/epidemiology1996-06
33 Buchi, Karen F.; Varner, Michael W.Prevalence of substance abuse among pregnant women in Utah.OBJECTIVE: To determine the rate of substance use among Utah's pregnant women, who are primarily white and middle class, for comparison to rates reported in studies of inner-city populations. METHODS: Urine specimens and demographic data were obtained anonymously from women who delivered infants at ...Substance Abuse; Pregnancy; Utah/epidemiology1993-02
34 Varner, Michael W.; Esplin, Michael S.Progression of pulmonary arteriovenous malformation during pregnancy: case report and review of the literature.Arteriovenous Malformations; Pulmonary Artery; Pregnancy Complications; Pulmonary Veins; Pulmonary Artery1997-04
35 Varner, Michael W.; Digre, Kathleen B.Pseudotumor cerebri and pregnancy.Pseudotumor cerebri (PTC) is most commonly seen in obese women of reproductive age. We studied 109 women with PTC between ages 16 and 44 years. In 11, PTC started during pregnancy. Thirteen women with previous diagnosis of PTC, including two of the aforementioned 11, had an additional 17 documented ...Pregnancy Complications; Pseudotumor Cerebri; Vision disorders; Headache; Intracranial Pressure1984-06
36 Varner, Michael W.Randomized study of closure of the peritoneum at cesarean delivery.This study was conducted to test the hypothesis that nonclosure of the visceral and parietal peritoneum during low transverse cervical cesarean delivery is not associated with increased intraoperative or immediate postoperative complications. One hundred thirteen patients scheduled for low transvers...Cesarean Section; Postoperative Complications; Visceral and Parietal Peritoneum closure1991-06
37 Varner, Michael W.; Hatasaka, Harry H.Recurrent pregnancy loss.Recurrent pregnancy loss is a frustrating clinical dilemma for both patients and physicians because, in most cases, causes are nebulous and few treatments with proven benefit can be offered. Involved, expensive tests have frequently been proposed and their use has often filtered into clinical practi...Recurrent Pregnancy Loss; Uterus/abnormalities; Chromosome Disorders; Abortion, Habitual1994-06
38 Varner, Michael W.Reduction in amniocentesis risks using a real-time needle guide procedure.Rates of complications associated with a second trimester genetic amniocentesis were studied in 918 patients, and complete infant follow-up was obtained. In 903 singleton pregnancies and 15 twin gestations, the procedure was performed under continuous sector scanning guidance through an attached nee...Amniocentesis; Ultrasonography; Pregnancy2007-01-25
39 Varner, Michael W.; Porter T. FlintRisk of preterm birth across generations.OBJECTIVE: To examine the risk of preterm birth for mothers who themselves were born before term. METHODS: Data were taken from a linked data base of birth certificates composed of two cohorts: 1) a parental cohort of women born between 1947 and 1957 and 2) their offspring born between 1970 and 1992...Preterm mothers; Pregnancy; Premature; Risk1997-07
40 Varner, Michael W.Risk of uterine rupture with a trial of labor in women with multiple and single prior cesarean delivery.OBJECTIVE: To determine whether the risk for uterine rupture is increased in women attempting vaginal birth after multiple cesarean deliveries. METHODS: We conducted a prospective multicenter observational study of women with prior cesarean delivery undergoing trial of labor and elective repeat oper...Cesarean Section, Repeat; Uterine Rupture; Vaginal Birth after Cesarean; Obstetric Labor Complications/surgery2006-07
41 Frazer, John K.Rituximab with chemotherapy in children and adolescents with central nervous system and/or bone marrow-positive Burkitt lymphoma/leukaemia: a childrens oncology group reportApproximately 1 in 4 children and adolescents with de-novo mature and Burkitt lymphoma (BL) present with high-risk disease that is either mature B-cell leukaemia (bone marrow ≥ 25% blasts [BM]) and/or have central nervous system (CNS) involvement. Both the Berlin-Frankfurt- Münster (BFM) and Fre...2014-01-01
42 Varner, Michael W.; Clark, Edward B.; Fernando, Kumari L.; Mathews, V. JohnRobust estimation of fetal heart rate variability using Doppler ultrasound.This paper presents a new measure of heart rate variability (HRV) that can be estimated using Doppler ultrasound techniques and is robust to variations in the angle of incidence of the ultrasound beam and the measurement noise. This measure employs the multiple signal characterization (MUSIC) algori...Prenatal Ultrasonography; Fetal Heart Rate; Blood Flow Velocity; Algorithms2003-08
43 Moon, Ann M.; Capecchi, Mario R.Roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth.Although numerous molecules required for limb bud formation have recently been identified, the molecular pathways that initiate this process and ensure that limb formation occurs at specific axial positions have yet to be fully elucidated. Based on experiments in the chick, Fgf8 expression in the in...Animals; Apoptosis; Forelimb; Gene Expression Regulation, Developmental; High Mobility Group Proteins; Hindlimb; In Situ Hybridization; Mesoderm; Mice, Mutant Strains; Trans-Activators2004-09
44 Varner, Michael W.Serial salivary estriol to detect an increased risk of preterm birth.OBJECTIVE: To evaluate serial measurements of salivary estriol (E3) to detect increased risk of spontaneous preterm labor and preterm birth. METHODS: A masked, prospective, multicenter trial of 956 women with singleton pregnancies was completed at eight United States medical centers. Saliva was coll...Estriol; Preterm Birth; Spontaneous Preterm Labor2000-10
45 Varner, Michael W.; Jackson, G. MarcSevere pulmonary hypertension in pregnancy following successful repair of ventricular septal defect in childhood.BACKGROUND: Because of advances in surgical repair, an increasing number of women born with structural cardiac disease now live to reproductive age. Patients treated successfully in childhood are followed for varying periods of time, then may be lost to follow-up or told that no follow-up is necessa...Pregnancy Complications, Cardiovascular; Heart Septal Defects, Ventricular; Hypertension, Pulmonary1993-10
46 Wen, Ming; Van Duker, Heather; Olson, Lenora MarySocial contexts of regular smoking in adolescence: towards a multidimensional ecological modelUsing data from the Longitudinal Study of Adolescent Health (Add Health), this study investigates factors at the individual, family, peer, school, neighborhood, and state levels that are important for subsequent adolescent cigarette regular smoking after controlling for the baseline smoking behavio...Adolescent smoking; Social capital; Family; Neighborhood; School; Teenagers; Teenage smoking2006-09-19
47 Varner, Michael W.Spontaneous resolution of asymptomatic Chlamydia trachomatis in pregnancy.OBJECTIVE: We sought to estimate the rate of spontaneous resolution of asymptomatic Chlamydia trachomatis in pregnancy and to evaluate factors associated with its resolution. METHODS: A cohort of women enrolled in a large multicenter randomized bacterial vaginosis antibiotic trial (metronidazole ver...Pregnancy; Chlamydia Trachomatis; Sexually Transmitted Diseases2005-03
48 Varner, Michael W.Systemic lupus erythematosus.Systemic lupus erythematosus is an autoimmune disease of unresolved cause afflicting predominantly women in their childbearing years. Speculation exists as to the relative roles of viruses, histocompatibility loci such as HLA-DR3, and estrogenmediated decreases in suppressor cell function. Whateve...Systemic Lupus Erythematosus; Pregnancy Complications1983-09
49 Moon, Anne M.TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-Mammary SyndromeTBX3 is a member of the T-box family of transcription factors with critical roles in development, oncogenesis, cell fate, and tissue homeostasis. TBX3 mutations in humans cause complex congenital malformations and Ulnar-mammary syndrome. Previous investigations into TBX3 function focused on its acti...2014-01-01
50 Varner, Michael W.Trial of labor or repeat cesarean delivery in women with morbid obesity and previous cesarean delivery.OBJECTIVE: Assess effects of body mass index (BMI) on trial of labor after previous cesarean delivery and determine whether morbidly obese women have greater maternal and perinatal morbidity with trial of labor compared with elective repeat cesarean delivery. METHODS: Secondary analysis from a prosp...Pregnancy Outcome; Obesity; Repeat Cesarean Section; Body Mass Index2006-07
51 Dolcourt, John L.; Hales, Joseph W.Use of internet searches for physician learningINTRODUCTION In 2005 the American Medical Association (AMA) approved the structure for awarding continuing medial education (CME) credit to physicians searching the Internet for answers to point-of-care related questions. Previous investigations of how physicians use the Intenet have relied on...Trapeze Interactive Poster2009
52 Varner, Michael W.X-ray pelvimetry in clinical obstetrics.X-ray pelvimetry has been used in obstetrics for over 80 years, but its clinical usefulness remains uncertain. Review of 101 consecutive x-ray pelvimetries obtained by Brown's modification of the Colcher-Sussman technique demonstrated the anteroposterior measurements to be of no value in predicting ...X-rey Pelvimetry;Labor Presentation; Ultrasonography; Abdominal Scout Film1980-09
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