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1 Moon, Anne M.TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-Mammary SyndromeTBX3 is a member of the T-box family of transcription factors with critical roles in development, oncogenesis, cell fate, and tissue homeostasis. TBX3 mutations in humans cause complex congenital malformations and Ulnar-mammary syndrome. Previous investigations into TBX3 function focused on its acti...2014-01-01
2 Dolcourt, John L.; Hales, Joseph W.Use of internet searches for physician learningINTRODUCTION In 2005 the American Medical Association (AMA) approved the structure for awarding continuing medial education (CME) credit to physicians searching the Internet for answers to point-of-care related questions. Previous investigations of how physicians use the Intenet have relied on...Trapeze Interactive Poster2009
3 Varner, Michael W.Elevations of amniotic fluid macrophage inflammatory protein-1 alpha concentrations in women during term and preterm labor.OBJECTIVE: To determine whether elevated concentrations of macrophage inflammatory protein-1 alpha (MIP-1 alpha) in amniotic fluid (AF) are related to term and preterm labor. METHODS: Amniotic fluid was obtained from women from five different clinical situations: 1) term cesarean delivery, no labor ...Amniotic Fluid; Macrophage Inflammatory Protein-1; Obstetric Labor, Premature1996-01
4 Varner, Michael W.Association of obesity with pulmonary and nonpulmonary complications of pregnancy in asthmatic women.OBJECTIVE: To evaluate whether maternal obesity is associated with pulmonary and nonpulmonary pregnancy complications in asthmatic women. METHODS: This is a secondary analysis of the prospective cohort Asthma During Pregnancy Study. Asthma patients were classified as having either mild or moderate t...Asthma; Body Mass Index; Pregnancy Outcome; Lung Diseases2006-07
5 Varner, Michael W.; Cannon, Cynthia; Ward, RobertPopulation-based study of congenital diaphragmatic hernia in Utah: 1988-1994.OBJECTIVE: To define the natural history of congenital diaphragmatic hernia and to determine the potential impact of fetal therapy. METHODS: This retrospective case series consisted of all fetuses and neonates with congenital diaphragmatic hernia born between 1988 and 1994 in the state of Utah that ...Hernia, Diaphragmatic; Fetal Diseases; Prenatal Diagnosis; Utah/epidemiology1996-06
6 Kriesel, John D.; Gooch, Willis M.; Pavia, Andrew T.Invasive sinonasal disease due to Scopulariopsis candida: case report and review of scopulariopsosis.Sinonasal infection with fungi of the order Mucorales--termed mucormycosis or zygomycosis--is sometimes seen in immunosuppressed patients, including those with diabetic ketoacidosis and malignancy. We describe a case of invasive sinonasal infection with Scopulariopsis candida (not among the Mucorale...Granulocyte Colony-Stimulating Factor; Itraconazole; Maxillary Sinus1994
7 Varner, Michael W.hPL: physiologic and pathophysiologic observations.Serum human placental lactogen (hPL) levels were studied in 806 women in late pregnancy. The hPL levels were positively correlated with birth weight but were unrelated to maternal age, parity, socioeconomic status, or the sex of the newborn. The hPL levels peaked at 37 weeks' gestation and then decl...hPL; Pregnancy Complications; Pregnancy, Multiple; Infant, Newborn; Birth Weight1979-08
8 Varner, Michael W.Reduction in amniocentesis risks using a real-time needle guide procedure.Rates of complications associated with a second trimester genetic amniocentesis were studied in 918 patients, and complete infant follow-up was obtained. In 903 singleton pregnancies and 15 twin gestations, the procedure was performed under continuous sector scanning guidance through an attached nee...Amniocentesis; Ultrasonography; Pregnancy2007-01-25
9 Varner, Michael W.Risk of uterine rupture with a trial of labor in women with multiple and single prior cesarean delivery.OBJECTIVE: To determine whether the risk for uterine rupture is increased in women attempting vaginal birth after multiple cesarean deliveries. METHODS: We conducted a prospective multicenter observational study of women with prior cesarean delivery undergoing trial of labor and elective repeat oper...Cesarean Section, Repeat; Uterine Rupture; Vaginal Birth after Cesarean; Obstetric Labor Complications/surgery2006-07
10 Varner, Michael W.Abnormal pregnancy sonogram: selective indication for fetal karyotype.The inability to make a definitive diagnosis in the fetus with a sonographically identified abnormality often results in parental and physician uncertainty. An antenatal chromosome evaluation could resolve this uncertainty. Forty-one fetuses with an abnormal ultrasound examination were tested for ka...Chromosome Disorders; Pregnancy; Karyotyping; Abnormalities; Amniocentesis1987-01
11 Varner, Michael W.; Esplin, Michael S.Progression of pulmonary arteriovenous malformation during pregnancy: case report and review of the literature.Arteriovenous Malformations; Pulmonary Artery; Pregnancy Complications; Pulmonary Veins; Pulmonary Artery1997-04
12 Varner, Michael W.; Porter T. FlintRisk of preterm birth across generations.OBJECTIVE: To examine the risk of preterm birth for mothers who themselves were born before term. METHODS: Data were taken from a linked data base of birth certificates composed of two cohorts: 1) a parental cohort of women born between 1947 and 1957 and 2) their offspring born between 1970 and 1992...Preterm mothers; Pregnancy; Premature; Risk1997-07
13 Varner, Michael W.Does progesterone treatment influence risk factors for recurrent preterm delivery?OBJECTIVE: To examine how demographic and pregnancy characteristics can affect the risk of recurrent preterm delivery and the how the effectiveness of progesterone treatment for prevention alters these relationships. METHODS: This was a secondary analysis of a randomized trial of 17alpha-hydroxyprog...Preterm Delivery; Progesterone Treatment; Pregnancy; Risk Factors2005-09
14 Varner, Michael W.Decision-to-incision times and maternal and infant outcomes.OBJECTIVE: To measure decision-to-incision intervals and related maternal and neonatal outcomes in a cohort of women undergoing emergency cesarean deliveries at multiple university-based hospitals comprising the National Institute of Child Health and Human Development Maternal-Fetal Medicine Units N...Cesarean Section; Fetal Distress; Outcome Assessment; Fetal Distress2006-07
15 Varner, Michael W.Complications of anesthesia for cesarean delivery.OBJECTIVE: To quantify anesthesia-related complications associated with cesarean delivery in a well-described, prospectively ascertained cohort from multiple university-based hospitals in the United States and to evaluate whether certain factors would identify women at increased risk for a failed re...Cesarean Section; Complications of Anesthesia2005-08
16 Varner, Michael W.; Hatasaka, Harry H.Recurrent pregnancy loss.Recurrent pregnancy loss is a frustrating clinical dilemma for both patients and physicians because, in most cases, causes are nebulous and few treatments with proven benefit can be offered. Involved, expensive tests have frequently been proposed and their use has often filtered into clinical practi...Recurrent Pregnancy Loss; Uterus/abnormalities; Chromosome Disorders; Abortion, Habitual1994-06
17 Hansen, Mark S.; Coffin, Cheryl M.; Capecchi, Mario R.Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.To investigate the role of the translocation-associated gene Pax3:Fkhr in alveolar rhabdomyosarcomas, we generated a Cre-mediated conditional knock-in of Pax3:Fkhr into the mouse Pax3 locus. Exploring embryonic tumor cell origins, we replaced a Pax3 allele with Pax3:Fkhr throughout its expression do...Neuroprogenitor; Embryogenesis2004-11-01
18 Varner, Michael W.Serial salivary estriol to detect an increased risk of preterm birth.OBJECTIVE: To evaluate serial measurements of salivary estriol (E3) to detect increased risk of spontaneous preterm labor and preterm birth. METHODS: A masked, prospective, multicenter trial of 956 women with singleton pregnancies was completed at eight United States medical centers. Saliva was coll...Estriol; Preterm Birth; Spontaneous Preterm Labor2000-10
19 Varner, Michael W.Asthma during pregnancyOBJECTIVE: To determine neonatal and maternal outcomes stratified by asthma severity during pregnancy by using the 1993 National Asthma Education Program Working Group on Asthma and Pregnancy definitions of asthma severity. The primary hypothesis was that moderate or severe asthmatics would have an ...Asthma; Infant, Newborn; Pregnancy Outcomes2004-01
20 Varner, Michael W.; Clark, Edward B.; Fernando, Kumari L.; Mathews, V. JohnRobust estimation of fetal heart rate variability using Doppler ultrasound.This paper presents a new measure of heart rate variability (HRV) that can be estimated using Doppler ultrasound techniques and is robust to variations in the angle of incidence of the ultrasound beam and the measurement noise. This measure employs the multiple signal characterization (MUSIC) algori...Prenatal Ultrasonography; Fetal Heart Rate; Blood Flow Velocity; Algorithms2003-08
21 Varner, Michael W.Systemic lupus erythematosus.Systemic lupus erythematosus is an autoimmune disease of unresolved cause afflicting predominantly women in their childbearing years. Speculation exists as to the relative roles of viruses, histocompatibility loci such as HLA-DR3, and estrogenmediated decreases in suppressor cell function. Whateve...Systemic Lupus Erythematosus; Pregnancy Complications1983-09
22 Varner, Michael W.Trial of labor or repeat cesarean delivery in women with morbid obesity and previous cesarean delivery.OBJECTIVE: Assess effects of body mass index (BMI) on trial of labor after previous cesarean delivery and determine whether morbidly obese women have greater maternal and perinatal morbidity with trial of labor compared with elective repeat cesarean delivery. METHODS: Secondary analysis from a prosp...Pregnancy Outcome; Obesity; Repeat Cesarean Section; Body Mass Index2006-07
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