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1 Varner, Michael W.Risk of uterine rupture with a trial of labor in women with multiple and single prior cesarean delivery.OBJECTIVE: To determine whether the risk for uterine rupture is increased in women attempting vaginal birth after multiple cesarean deliveries. METHODS: We conducted a prospective multicenter observational study of women with prior cesarean delivery undergoing trial of labor and elective repeat oper...Cesarean Section, Repeat; Uterine Rupture; Vaginal Birth after Cesarean; Obstetric Labor Complications/surgery2006-07
2 Varner, Michael W.Complications of anesthesia for cesarean delivery.OBJECTIVE: To quantify anesthesia-related complications associated with cesarean delivery in a well-described, prospectively ascertained cohort from multiple university-based hospitals in the United States and to evaluate whether certain factors would identify women at increased risk for a failed re...Cesarean Section; Complications of Anesthesia2005-08
3 Varner, Michael W.Intergenerational predisposition to operative delivery.OBJECTIVE: To determine the risk of cesarean delivery for women who themselves were born via operative delivery. METHODS: A linked data base was constructed between the birth certificates of individuals born in Utah during 1947-1957 (parental cohort) and who subsequently became a parent of offspring...Cesarean Section; Cohort Studies; Delivery, Obstetric; Obstetric Labor Complications1996-06
4 Varner, Michael W.Blood transfusion and cesarean delivery.OBJECTIVE: To evaluate risks for intraoperative or postoperative packed red blood cell transfusion in women who underwent cesarean delivery. METHODS: This was a 19-university prospective observational study. All primary cesarean deliveries from January 1, 1999, to December 31, 2000, and all repeat c...Blood Transfusion; Postpartum Hemorrhage; Pregnancy Complications; Anemia2006-10
5 Varner, Michael W.Decision-to-incision times and maternal and infant outcomes.OBJECTIVE: To measure decision-to-incision intervals and related maternal and neonatal outcomes in a cohort of women undergoing emergency cesarean deliveries at multiple university-based hospitals comprising the National Institute of Child Health and Human Development Maternal-Fetal Medicine Units N...Cesarean Section; Fetal Distress; Outcome Assessment; Fetal Distress2006-07
6 Dolcourt, John L.; Hales, Joseph W.Use of internet searches for physician learningINTRODUCTION In 2005 the American Medical Association (AMA) approved the structure for awarding continuing medial education (CME) credit to physicians searching the Internet for answers to point-of-care related questions. Previous investigations of how physicians use the Intenet have relied on...Trapeze Interactive Poster2009
7 Varner, Michael W.; Porter T. FlintRisk of preterm birth across generations.OBJECTIVE: To examine the risk of preterm birth for mothers who themselves were born before term. METHODS: Data were taken from a linked data base of birth certificates composed of two cohorts: 1) a parental cohort of women born between 1947 and 1957 and 2) their offspring born between 1970 and 1992...Preterm mothers; Pregnancy; Premature; Risk1997-07
8 Varner, Michael W.Human placental lactogen: a predictor of perinatal outcome?Serial human placental lactogen (hPL) determinations were performed on 806 women with normal and abnormal pregnancies late in the pregnancy. These results were not reported to the clinicians involved. For the study population as a whole, low hPL levels did not effectively predict those adverse perin...Infant, Newborn; Placental Lactogen; Pregnancy; Prenatal Diagnosis1979-08
9 Varner, Michael W.Fetal injury associated with cesarean delivery.OBJECTIVE: To describe the incidence and type of fetal injury identified in women undergoing cesarean delivery. METHODS: Between January 1, 1999, and December 31, 2000, a prospective cohort study of all cesarean deliveries was conducted at 13 university centers. Information regarding maternal and in...Birth Injuries; Cesarean Section; Adverse Effects2006-10
10 Buchi, Karen F.; Varner, Michael W.Changing prevalence of prenatal substance abuse in Utah.OBJECTIVE: To estimate the current prevalence of prenatal exposure to methamphetamines and other drugs of abuse among infants born in Utah and compare the results with those of a maternal substance abuse prevalence study performed in 1991 in the same geographic area. METHODS: Thirteen well baby nurs...Street Drugs; Prenatal Care; Maternal Exposure; Infant, Newborn2003-06-12
11 Varner, Michael W.hPL: physiologic and pathophysiologic observations.Serum human placental lactogen (hPL) levels were studied in 806 women in late pregnancy. The hPL levels were positively correlated with birth weight but were unrelated to maternal age, parity, socioeconomic status, or the sex of the newborn. The hPL levels peaked at 37 weeks' gestation and then decl...hPL; Pregnancy Complications; Pregnancy, Multiple; Infant, Newborn; Birth Weight1979-08
12 Frazer, John K.Rituximab with chemotherapy in children and adolescents with central nervous system and/or bone marrow-positive Burkitt lymphoma/leukaemia: a childrens oncology group reportApproximately 1 in 4 children and adolescents with de-novo mature and Burkitt lymphoma (BL) present with high-risk disease that is either mature B-cell leukaemia (bone marrow ≥ 25% blasts [BM]) and/or have central nervous system (CNS) involvement. Both the Berlin-Frankfurt- Münster (BFM) and Fre...2014-01-01
13 Varner, Michael W.Trial of labor or repeat cesarean delivery in women with morbid obesity and previous cesarean delivery.OBJECTIVE: Assess effects of body mass index (BMI) on trial of labor after previous cesarean delivery and determine whether morbidly obese women have greater maternal and perinatal morbidity with trial of labor compared with elective repeat cesarean delivery. METHODS: Secondary analysis from a prosp...Pregnancy Outcome; Obesity; Repeat Cesarean Section; Body Mass Index2006-07
14 Varner, Michael W.; Clark, Edward B.; Fernando, Kumari L.; Mathews, V. JohnRobust estimation of fetal heart rate variability using Doppler ultrasound.This paper presents a new measure of heart rate variability (HRV) that can be estimated using Doppler ultrasound techniques and is robust to variations in the angle of incidence of the ultrasound beam and the measurement noise. This measure employs the multiple signal characterization (MUSIC) algori...Prenatal Ultrasonography; Fetal Heart Rate; Blood Flow Velocity; Algorithms2003-08
15 Varner, Michael W.Serial salivary estriol to detect an increased risk of preterm birth.OBJECTIVE: To evaluate serial measurements of salivary estriol (E3) to detect increased risk of spontaneous preterm labor and preterm birth. METHODS: A masked, prospective, multicenter trial of 956 women with singleton pregnancies was completed at eight United States medical centers. Saliva was coll...Estriol; Preterm Birth; Spontaneous Preterm Labor2000-10
16 Varner, Michael W.Spontaneous resolution of asymptomatic Chlamydia trachomatis in pregnancy.OBJECTIVE: We sought to estimate the rate of spontaneous resolution of asymptomatic Chlamydia trachomatis in pregnancy and to evaluate factors associated with its resolution. METHODS: A cohort of women enrolled in a large multicenter randomized bacterial vaginosis antibiotic trial (metronidazole ver...Pregnancy; Chlamydia Trachomatis; Sexually Transmitted Diseases2005-03
17 Varner, Michael W.Association of obesity with pulmonary and nonpulmonary complications of pregnancy in asthmatic women.OBJECTIVE: To evaluate whether maternal obesity is associated with pulmonary and nonpulmonary pregnancy complications in asthmatic women. METHODS: This is a secondary analysis of the prospective cohort Asthma During Pregnancy Study. Asthma patients were classified as having either mild or moderate t...Asthma; Body Mass Index; Pregnancy Outcome; Lung Diseases2006-07
18 Varner, Michael W.X-ray pelvimetry in clinical obstetrics.X-ray pelvimetry has been used in obstetrics for over 80 years, but its clinical usefulness remains uncertain. Review of 101 consecutive x-ray pelvimetries obtained by Brown's modification of the Colcher-Sussman technique demonstrated the anteroposterior measurements to be of no value in predicting ...X-rey Pelvimetry;Labor Presentation; Ultrasonography; Abdominal Scout Film1980-09
19 Varner, Michael W.Elevations of amniotic fluid macrophage inflammatory protein-1 alpha concentrations in women during term and preterm labor.OBJECTIVE: To determine whether elevated concentrations of macrophage inflammatory protein-1 alpha (MIP-1 alpha) in amniotic fluid (AF) are related to term and preterm labor. METHODS: Amniotic fluid was obtained from women from five different clinical situations: 1) term cesarean delivery, no labor ...Amniotic Fluid; Macrophage Inflammatory Protein-1; Obstetric Labor, Premature1996-01
20 Wen, Ming; Van Duker, Heather; Olson, Lenora MarySocial contexts of regular smoking in adolescence: towards a multidimensional ecological modelUsing data from the Longitudinal Study of Adolescent Health (Add Health), this study investigates factors at the individual, family, peer, school, neighborhood, and state levels that are important for subsequent adolescent cigarette regular smoking after controlling for the baseline smoking behavio...Adolescent smoking; Social capital; Family; Neighborhood; School; Teenagers; Teenage smoking2006-09-19
21 Varner, Michael W.Elevated second-trimester maternal serum hCG: a marker of inadequate angiogenesis.OBJECTIVE: To measure angiogenin, a potent inducer of neovascularization and interleukin-6, as an indicator of acute inflammation, in second-trimester amniotic fluid of patients with elevated maternal serum hCG. METHODS: In this case-control study, 20 patients with elevated maternal serum hCG (at le...Angiogenesis Inducing Agents; Interleukin-6; Pregnancy Complications; hCG1998-04
22 Hansen, Mark S.; Coffin, Cheryl M.; Capecchi, Mario R.Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.To investigate the role of the translocation-associated gene Pax3:Fkhr in alveolar rhabdomyosarcomas, we generated a Cre-mediated conditional knock-in of Pax3:Fkhr into the mouse Pax3 locus. Exploring embryonic tumor cell origins, we replaced a Pax3 allele with Pax3:Fkhr throughout its expression do...Neuroprogenitor; Embryogenesis2004-11-01
23 Varner, Michael W.Episiotomy: techniques and indications.In current obstetric practice episiotomy is generally taken to refer to an incision of the perineum and vagina to facilitate vaginal delivery. While the most precise definition of this incision is perineotomy, episiotomy is the generally employed terminology and thus is used in this article. The e...Episiotomy; Adverse Effects; Perineotomy1986-06
24 Varner, Michael W.Asthma during pregnancyOBJECTIVE: To determine neonatal and maternal outcomes stratified by asthma severity during pregnancy by using the 1993 National Asthma Education Program Working Group on Asthma and Pregnancy definitions of asthma severity. The primary hypothesis was that moderate or severe asthmatics would have an ...Asthma; Infant, Newborn; Pregnancy Outcomes2004-01
25 Moon, Ann M.; Capecchi, Mario R.Roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth.Although numerous molecules required for limb bud formation have recently been identified, the molecular pathways that initiate this process and ensure that limb formation occurs at specific axial positions have yet to be fully elucidated. Based on experiments in the chick, Fgf8 expression in the in...Animals; Apoptosis; Forelimb; Gene Expression Regulation, Developmental; High Mobility Group Proteins; Hindlimb; In Situ Hybridization; Mesoderm; Mice, Mutant Strains; Trans-Activators2004-09
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