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| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
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Digre, Kathleen B.; Gouw, Launce G.; Harris, Catherine P.; Haines, John H.; Ptacek, L.J. | Autosomal dominant cerebellar ataxia with retinal degeneration: clinical, neuropathologic, and genetic analysis of a large kindred. | The autosomal dominant cerebellar ataxias (ADCA) comprise a heterogeneous group of neurologic disorders characterized by degeneration of the cerebellum, spinal cord, and brainstem. Genetic analysis has revealed two loci, SCA1 on chromosome 6p, and SCA2 on chromosome 12q, responsible for some ADCA. W... | Retinal Degeneration; Cerebellar Ataxia; Genetic Analysis | 1994-08 |
| 2 |
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Kriesel, John D.; Baringer, J R; Spruance, Spotswood L. | Correlation between detection of herpes simplex virus in oral secretions by PCR and susceptibility to experimental UV radiation-induced herpes labialis. | We examined the oral secretions of 25 patients for herpes simplex virus (HSV) at the time of and following experimental UV radiation (UVR). HSV was detected in one or more oral secretion specimens in 5 of 12 (42%) cases by cell culture and in 8 of 12 (67%) cases by PCR. On the day of UVR, HSV was de... | Polymerase Chain Reaction; Ultraviolet Rays; Simplexvirus | 1994 |
| 3 |
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Aldous, Jay A.; Engar, Richard C. | Do dentists prescribe narcotics excessively? | Dealing with pain is an inevitable sequela to dental treatment. Although several drug regimens primarily involving narcotics have been used in the past, availability of nonsteroidal anti-inflammatory drugs (NSAIDs) has increased recently. A study was conducted to analyze dental prescribing patterns ... | Analgesics, Opioid; Anti-Inflammatory Agents; Dentist's Practice Patterns; Pain, Postoperative | 1996-07-01 |
| 4 |
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Normann, Richard A.; Chandler, John P. | Effects of calcium ions on L-type horizontal cells in the isolated turtle retina | A technique by which the retina can be isolated from the turtle eye is described. Scanning electron microscopy revealed morphological variability between preparations and also between regions of the same one. Large areas were often totally free of any pigment epithelial cells, yet contained a high p... | Retina; Calcium; Horizontal Cell; Turtle | 1990 |
| 5 |
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Eichwald, Ernst; Capecchi, Mario R.; Thomas, Kirk R. | Mouse model for the delta F508 allele of cystic fibrosis | The most common cause of cystic fibrosis is a mutation that deletes phenylalanine 508 in cystic fibrosis transmembrane conductance regulator (CFTR). The delta F508 protein is misprocessed and degraded rather than traveling to the apical membrane. We used a novel strategy to introduce the delta F508 ... | Digestive System; Disease Models, Animal; Electrolytes; Mice, Inbred C57BL | 1995-10 |
| 6 |
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Kriesel, John D.; Spruance, Spotswood L.; Daynes, Raymond A. | Nucleic acid vaccine encoding gD2 protects mice from herpes simplex virus type 2 disease. | Nucleic acid vaccinations with plasmids pWW65, containing the sequence for herpes simplex type 2 (HSV-2) gD2, and pRSVnt, lacking the gD sequence, were studied. Groups of mice were immunized with pWW65 alone, pWW65 plus 1,25-dihydroxyvitamin-D3 (D3), or pRSVnt. Clinical disease (vaginitis), serum an... | Mice, Inbred BALB C; Plasmids; Viral Vaccines | 1996 |
| 7 |
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Jaskowski, Troy D. | Polymerase chain reaction detection of Lyme disease: correlation with clinical manifestations and serologic responses | The Author's have developed a simple, nested polymerase chain reaction (PCR) assay for amplification of an outer surface protein A (OspA) gene fragment of Borrelia burgdorferi using rapid temperature cycling and ethidium bromide detection on agarose gels, and applied it to the diagnosis of Lyme dis... | PCR; Rapid cycle amplification | 1996 |
| 8 |
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Jaskowski, Troy D. | Screening for antinuclear antibodies by enzyme immunoassay | Indirect fluorescent antibody (IFA) is the most widely used method in clinical laboratories to screen for autoantibodies against a wide variety of nuclear antigens. Recently, a number of antinuclear antibody (ANA) enzyme immunoassay (EIA) screens have become commercially available and claim to be an... | Antinuclear antibodies; Enzyme immunoassay | 1996 |
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