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Creator | Title | Description | Subject | Date |
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Bernstein, Paul S. | Skin carotenoid status measured by resonance Raman spectroscopy as a biomarker of fruit and vegetable intake in preschool children | Background/Objective: Dietary assessment in children is difficult, suggesting a need to develop more objective biomarkers of intake. Resonance Raman spectroscopy (RRS) is a noninvasive, validated method of measuring carotenoid status in skin as a biomarker of fruit/vegetable intake. The purpose of t... | | 2012-01-01 |
| 2 |
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Frederick, Jeanne M. | The prenyl-binding protein PrBP/δ: A chaperone participating in intracellular trafficking | Expressed ubiquitously, PrBP/d functions as chaperone/co-factor in the transport of a subset of prenylated proteins. PrBP/d features an immunoglobulin-like b-sandwich fold for lipid binding, and interacts with diverse partners. PrBP/d binds both C-terminal C15 and C20 prenyl side chains of phototran... | | 2012-01-01 |
| 3 |
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Bernstein, Paul S. | Senior-Løken syndrome: a syndromic form of retinal dystrophy associated with nephronophthisis | Senior-Løken syndrome (SLS) is an autosomal recessive disease characterized by development of a retinitis (RP)- or Leber congenital amaurosis (LCA)-like retinal dystrophy and a medullary cystic kidney disease, nephronophthisis. Mutations in several genes (called nephrocystins) have been shown to ca... | | 2012-01-01 |
| 4 |
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Frederick, Jeanne M. | Uncoordinated (UNC)119: Coordinating the trafficking of myristoylated proteins | The mechanism by which myristoylated proteins are targeted to specific subcellular membrane compartments is poorly understood. Two novel acyl-binding proteins, UNC119A and UNC119B, have been shown recently to function as chaperones/co-factors in the transport of myristoylated G protein a-subunits an... | | 2012-01-01 |
| 5 |
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Kriesel, John D. | Helicase-primase inhibitor pritelivir for HSV-2 infection | Background Pritelivir, an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. We tested the efficacy and safety of pritelivir in otherwise healthy persons with genital HSV-2 infection. Methods We randomly... | | 2014-01-01 |
| 6 |
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Moshirfar, Majid | The effect of preoperative keratometry on visual outcomes after moderate myopic LASIK | The relationship between preoperative keratometry (K) and visual outcomes in laser-assisted in situ keratomileusis (LASIK) has been studied in high myopia and hyperopia, but not in moderate myopia. Rao et al report increased undercorrection in eyes with preoperative spherical equivalent (SE) of −1... | | 2012-01-01 |
| 7 |
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Fuhrmann, Sabine | Extraocular ectoderm triggers dorsal retinal fate during optic vesicle evagination in zebrafish | Dorsal retinal fate is established early in eye development, via expression of spatially restricted dorsal‐specific transcription factors in the optic vesicle; yet the events leading to initiation of dorsal fate are not clear. We hypothesized that induction of dorsal fate would require an extraocu... | | 2012-01-01 |
| 8 |
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Crockett, David K. | Identification of histoplasma -specific peptides in human urine | Histoplasmosis is a severe dimorphic fungus infection, which is often difficult to diagnose due to similarity in symptoms to other diseases and lack of specific diagnostic tests. Urine samples from histoplasma-antigen-positive patients and appropriate controls were prepared using various sample prep... | | 2012-01-01 |
| 9 |
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Normann, Richard A. | Oscillations in rod and horizontal cell membrane potential: evidence for feed-back to rods in the vertebrate retina | 1. Rods and horizontal cells were studied with intracellular recordings in the retina of the toad, Bufo marinus; 161 cells were from the eyecup preparation and thirty were from the isolated perfused retina. 2. Of these cells, 39% exhibited either transient or sustained oscillations of membrane poten... | Retina; Photoreceptors; Toads; Adaptation, Ocular | 1976 |
| 10 |
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Baehr, Wolfgang; Katz, Bradley J.; Creel, Donnell J.; Zhang, Kang | Autosomal dominant cone dystrophy caused by a novel mutation in the GCAP1 gene (GUCA1A) | PURPOSE: To describe the clinical features and genetic analysis of a family with an autosomal dominant cone dystrophy (adCD). METHODS: Selected members of a family with an autosomal dominant cone dystrophy underwent ophthalmic evaluation. Blood samples were obtained, genomic DNA was isolated, and ge... | Mutation, Missense; DNA Mutational Analysis; Electroretinography | 2005 |
| 11 |
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Frederick, Jeanne M. | Inactivity of human β,β-carotene-9′, 10-′dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment | The macula of the primate retina uniquely concentrates high amounts of the xanthophyll carotenoids lutein, zeaxanthin, and meso-zeaxanthin, but the underlying biochemical mechanisms for this spatial- and species-specific localization have not been fully elucidated. For example, despite abundant reti... | | 2014-01-01 |
| 12 |
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Normann, Richard A. | Control of retinal sensitivity. I. Light and dark adaptation of vertebrate rods and cones | Rods and cones in Necturus respond with graded hyperpolarization to test flashes spanning about 3.5 log units of intensity. Steady background levels hyperpolarize the rods, and the rod responses become progressively smaller as background level is increased. In cones, higher background levels reduce... | Retina;Light and Dark Adaptation; Recepters; Bipolars; Ganglion Cells | 1974 |
| 13 |
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Digre, Kathleen B.; Couldwell, William T.; Amini, Amin | Photophobia in a blind patient: An alternate visual pathway. Case report. | Photophobia is a common neurological and ophthalmological symptom that has been associated with a growing number of neurosurgical conditions, especially compressive lesions. The exact signaling pathways and neurophysiological features of the disorder are not well understood; however, data from multi... | Photophobia, Blindness, Signaling Pathway, Pretectal Nuclei, Trigeminal Pathway | 2006-12-14 |
| 14 |
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Warner, Judith E. A. | Intermittent reversal of Complete Ptosis-EganWarner | CASE REPORT: Ptosis secondary to dense oculomotor pareses generally improves over several months, but intermittent elevation of the eyelid has not been reported. The Author's describe two patients who demonstrated intermittent involuntary monocular eyelid elevation in an eye with complete ptosis cau... | Eyelids; Ophthalmoplegia; Intraoperative Complications | 2006 |
| 15 |
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Baehr, Wolfgang | Cloning and molecular characterization of cGMP-gated ion channels from rod and cone photoreceptors of striped bass ( M. saxatilis ) retina | Vertebrate photoreceptors respond to light with changes in membrane conductance that reflect the activity of cyclic-nucleotide gated channels (CNG channels). The functional features of these channels differ in rods and cones; to understand the basis of these differences we cloned CNG channels from t... | Amino Acid Sequence; Computational Biology; Reverse Transcriptase Polymerase Chain Reaction | 2006 |
| 16 |
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Zhang, Kang | Molecular and developmental characterization of the heat shock cognate 4 gene of Drosophila melanogaster | The Drosophila heat shock cognate gene 4 (hsc4), a member of the hsp70 gene family, encodes an abundant protein, hsc70, that is more similar to the constitutively expressed human protein than the Drosophila heat-inducible hsp70. Developmental expression revealed that hsc4 transcripts are enriched in... | Embryo, Nonmammalian; Molecular Sequence Data | 1990 |
| 17 |
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Normann, Richard A.; Chandler, John P. | Effects of calcium ions on L-type horizontal cells in the isolated turtle retina | A technique by which the retina can be isolated from the turtle eye is described. Scanning electron microscopy revealed morphological variability between preparations and also between regions of the same one. Large areas were often totally free of any pigment epithelial cells, yet contained a high p... | Retina; Calcium; Horizontal Cell; Turtle | 1990 |
| 18 |
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Normann, Richard A. | Signal transmission from red cones to horizontal cells in the turtle retina | 1. Intracellular recordings were made from L-type horizontal cells in the retina of the turtle Pseudemys scripta elegans. The responses were evoked by 500 msec pulses of 'white' light. 2. L-type horizontal cells were classified as either, 'small receptive field' s.r.f. or 'large receptive field' l.r... | Turtles; Synapses; Retina; Photoreceptors | 1979 |
| 19 |
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Olson, Randall J. | Microphaco update | Microphacoemulsification, or cataract surgery using ultrasound through two small stab incisions. Wound burn is now not a problem with AMO's Sovereign system plus Whitestar technology. | Microphacoemulsification; Wound Burn; Cataract Extraction | 2002 |
| 20 |
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Baehr, Wolfgang | Light-dependent redistribution of visual arrestins and transducin subunits in mice with defective phototransduction | PURPOSE: The light-dependent redistribution of phototransduction components in photoreceptor cells plays a role in light adaptation. Upon illumination, rod and cone arrestins (Arr and cArr) translocate from the inner to the outer segments while transducin subunits (Talpha, Tbetagamma) translocate in... | Phototransduction; Protein Kinases; Rhodopsin Kinase | 2003 |
| 21 |
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Baehr, Wolfgang | Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver | Lecithin-retinol acyltransferase (LRAT), an enzyme present mainly in the retinal pigmented epithelial cells and liver, converts all-trans-retinol into all-trans-retinyl esters. In the retinal pigmented epithelium, LRAT plays a key role in the retinoid cycle, a two-cell recycling system that replenis... | Antibodies, Monoclonal; Chromatography, High Pressure Liquid; Microscopy, Fluorescence | 2004 |
| 22 |
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Olson, Randall J. | Clinical experience with 21-gauge manual microphacoemulsification using Sovereign WhiteStar Technology in eyes with dense cataract | PURPOSE: To present a series of patients who had 21-gauge microphacoemulsification using Sovereign WhiteStar technology. SETTING: John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA. METHODS: Eighteen consecutive patients with cataracts judged to be 3+ or 4+ on... | Cataract; Microsurgery; Phacoemulsification; Postoperative Complications; Visual Acuity | 2004-01 |
| 23 |
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Olson, Randall J. | Effect of lens edge design versus anterior capsule overlap on posterior capsule opacification | PURPOSE: To determine whether lens edge design or anterior capsule overlap on the intraocular lens (IOL) has greater effect on posterior capsule opacification (PCO). DESIGN: Retrospective cohort clinical study. METHODS: Retrospective. SETTING: Academic clinical practice. PATIENT POPULATION: The pati... | Posterior Capsular Opacification' Intraocular Lens; Anterior Capsular Opacification; Acrylic Lenses; Silicone Lenses | 2004-10 |
| 24 |
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Baehr, Wolfgang; Zhang, Kang | Elovl4 mRNA distribution in the developing mouse retina and phylogenetic conservation of Elovl4 genes | PURPOSE: Stargardt-like macular dystrophy (STGD3) is an autosomal dominant form of early onset macular degeneration. The disease causing gene ELOVL4 encodes a protein that belongs to a family of proteins functioning in elongation of long chain fatty acids. The purpose of this study is to characteriz... | Amino Acid Sequence; Cloning, Molecular; Molecular Sequence Data | 2003 |
| 25 |
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Digre, Kathleen B.; Warner, Judith E. A.; Bernstein, Paul S.; Alder, Stephen C. | Vitamin A in the cerebrospinal fluid of patients with and without idiopathic intracranial hypertension | We quantified vitamin A in the cerebrospinal fluid of patients with idiopathic intracranial hypertension, elevated intracranial pressure of other causes and normal intracranial pressure. Vitamin A could be detected by high-pressure liquid chromatography in most of the specimens. There was a signific... | Chromatography, High Pressure Liquid; Headache | 2002-11 |
