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1 Angelucci, AlessandraMultiple components of surround modulation in primary visual cortex: Multiple neural circuits with multiple functions?The responses of neurons in primary visual cortex (V1) to stimulation of their receptive field (RF) are modulated by stimuli in the RF surround. This modulation is suppressive when the stimuli in the RF and surround are of similar orientation, but less suppressive or facilitatory when they are cross...2014-01-01
2 Normann, Richard A.Acute human brain responses to intracortical microelectrode arrays: challenges and future prospectsThe emerging field of neuroprosthetics is focused on the development of new therapeutic interventions that will be able to restore some lost neural function by selective electrical stimulation or by harnessing activity recorded from populations of neurons. As more and more patients benefit from thes...2014-01-01
3 Frederick, Jeanne M.Inactivity of human β,β-carotene-9′, 10-′dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigmentThe macula of the primate retina uniquely concentrates high amounts of the xanthophyll carotenoids lutein, zeaxanthin, and meso-zeaxanthin, but the underlying biochemical mechanisms for this spatial- and species-specific localization have not been fully elucidated. For example, despite abundant reti...2014-01-01
4 Frederick, Jeanne M.Centrin 2 is required for mouse olfactory ciliary trafficking and development of ependymal cilia planar polarityCentrins are ancient calmodulin-related Ca2-binding proteins associated with basal bodies. In lower eukaryotes, Centrin2 (CETN2) is required for basal body replication and positioning, although its function in mammals is undefined. We generated a germline CETN2 knock-out (KO) mouse presenting with s...2014-01-01
5 Frederick, Jeanne M.RNA interference gene therapy in dominant retinitis pigmentosa and cone-rod dystrophy mouse models caused by GCAP1 mutationsRNA interference (RNAi) knockdown is an efficacious therapeutic strategy for silencing genes causative for dominant retinal dystrophies. To test this, we used self-complementry (sc) AAV2/8 vector to develop an RNAi-based therapy in two dominant retinal degeneration mouse models. The allele-specific ...2014-01-01
6 Kriesel, John D.Helicase-primase inhibitor pritelivir for HSV-2 infectionBackground Pritelivir, an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. We tested the efficacy and safety of pritelivir in otherwise healthy persons with genital HSV-2 infection. Methods We randomly...2014-01-01
7 Bernstein, Paul S.Reflection-based imaging of macular pigment distributions in infants and childrenWe have developed a reflection-based capability of the RetCam® platform, an FDA-cleared pediatric retinal-imaging instrument, for the purpose of measuring macular pigment levels as well as their spatial distributions in infants and children. Our modifications include narrow-band blue-wavelength exc...2013-01-01
8 Crockett, David K.Identification of histoplasma -specific peptides in human urineHistoplasmosis is a severe dimorphic fungus infection, which is often difficult to diagnose due to similarity in symptoms to other diseases and lack of specific diagnostic tests. Urine samples from histoplasma-antigen-positive patients and appropriate controls were prepared using various sample prep...2012-01-01
9 Bernstein, Paul S.Skin carotenoid status measured by resonance Raman spectroscopy as a biomarker of fruit and vegetable intake in preschool childrenBackground/Objective: Dietary assessment in children is difficult, suggesting a need to develop more objective biomarkers of intake. Resonance Raman spectroscopy (RRS) is a noninvasive, validated method of measuring carotenoid status in skin as a biomarker of fruit/vegetable intake. The purpose of t...2012-01-01
10 Jones, Bryan W.Online parameter estimation in dynamic Markov Random Fields for image sequence analysisMarkov Random Fields (MRF) have proven to be extremely useful models for efficient and accurate image segmentation.Recent literature points to an increased effort towards incorporating useful priors (shape, geometry, context) in a MRF framework. However, topological priors, considered extremely cruc...2012-01-01
11 Bernstein, Paul S.Senior-Løken syndrome: a syndromic form of retinal dystrophy associated with nephronophthisisSenior-Løken syndrome (SLS) is an autosomal recessive disease characterized by development of a retinitis (RP)- or Leber congenital amaurosis (LCA)-like retinal dystrophy and a medullary cystic kidney disease, nephronophthisis. Mutations in several genes (called nephrocystins) have been shown to ca...2012-01-01
12 Frederick, Jeanne M.The prenyl-binding protein PrBP/δ: A chaperone participating in intracellular traffickingExpressed ubiquitously, PrBP/d functions as chaperone/co-factor in the transport of a subset of prenylated proteins. PrBP/d features an immunoglobulin-like b-sandwich fold for lipid binding, and interacts with diverse partners. PrBP/d binds both C-terminal C15 and C20 prenyl side chains of phototran...2012-01-01
13 Frederick, Jeanne M.Uncoordinated (UNC)119: Coordinating the trafficking of myristoylated proteinsThe mechanism by which myristoylated proteins are targeted to specific subcellular membrane compartments is poorly understood. Two novel acyl-binding proteins, UNC119A and UNC119B, have been shown recently to function as chaperones/co-factors in the transport of myristoylated G protein a-subunits an...2012-01-01
14 Fuhrmann, SabineExtraocular ectoderm triggers dorsal retinal fate during optic vesicle evagination in zebrafishDorsal retinal fate is established early in eye development, via expression of spatially restricted dorsal‐specific transcription factors in the optic vesicle; yet the events leading to initiation of dorsal fate are not clear. We hypothesized that induction of dorsal fate would require an extraocu...2012-01-01
15 Normann, Richard A.Adaptive parameter selection for asynchronous intrafascicular multi-electrode stimulationThis paper describes an adaptive algorithm for selecting perelectrode stimulus intensities and inter-electrode stimulation phasing to achieve desired isometric plantar-flexion forces via asynchronous, intrafascicular multi-electrode stimulation. The algorithm employed a linear model of force product...2012-01-01
16 Moshirfar, MajidThe effect of preoperative keratometry on visual outcomes after moderate myopic LASIKThe relationship between preoperative keratometry (K) and visual outcomes in laser-assisted in situ keratomileusis (LASIK) has been studied in high myopia and hyperopia, but not in moderate myopia. Rao et al report increased undercorrection in eyes with preoperative spherical equivalent (SE) of −1...2012-01-01
17 Moshirfar, MajidDouble-pass microkeratome technique for ultra-thin graft preparation in Descemet's stripping automated endothelial keratoplastyEndothelial keratoplasty is evolving with increased attention placed on the optical qualities of the posterior donor lenticule. In efforts to improve visual outcomes, the effects of the thickness, smoothness, and planar profile are being studied. This paper describes a double-pass microkeratome tech...2012-01-01
18 Baehr, WolfgangCloning and sequence analysis of the major outer membrane protein genes of two Chlamydia psittaci strainsWe cloned and sequenced the gene encoding the major outer membrane protein (MOMP) of two Chlamydia psittaci strains, guinea pig inclusion conjunctivitis (GPIC) strain 1, and meningopneumonitis (Mn) strain Cal-10. Intraspecies alignment of the two C. psittaci MOMP genes revealed 80.6% similarity, and...Base Sequence; Cloning, Molecular; Amino Acid Sequence1989
19 Digre, Kathleen B.Significance of CT and MR findings in sphenoid sinus disease.Disorders of the paranasal sinuses, particularly the sphenoid sinus, can be associated with significant disorders of the optic and other cranial nerves. We examined 100 consecutive routine CT scans, 100 posterior fossa CT scans, and 100 MR scans to look for evidence of sinus disease, especially of t...Sphenoid Sinus; Vision Disorders; Paranasal Sinus Diseases; Magnetic Resonance Imaging1989-05
20 Frederick, Jeanne M.; Baehr, WolfgangReceptor for advanced glycation end products and age-related macular degeneration.Advanced glycation end products (AGE) exacerbate disease progression through two general mechanisms: modifying molecules and forming nondegradable aggregates, thus impairing normal cellular/tissue functions, and altering cellular function directly through receptor-mediated activation. In the present...Optic Atrophies, Hereditary; Apoptosis; Pigment Epithelium of Eye2004
21 Angelucci, Alessandra; Lund, Jennifer S.Circuits for local and global signal integration in primary visual cortexContrast-dependent changes in spatial summation and contextual modulation of primary visual cortex (V1) neuron responses to stimulation of their receptive field reveal long-distance integration of visual signals within V1, well beyond the classical receptive field (cRF) of single neurons. To identif...Primary Visual Cortex; Extrastriate Cortex; Feed-back Connections; Lateral Connections; SUrround Modulation; Macaque2002-10-01
22 Normann, Richard A.; Campbell, Patrick K.; Jones, Kelly E.; Huber, Robert J.; Horch, Kenneth W.Silicon-based, three-dimensional neural interface: manufacturing processes for an intracortical electrode arrayA method has been developed for the manufacture of a "three-dimensional" electrode array geometry for chronic intracortical stimulation. This silicon based array consists of a 4.2 x 4.2 x 0.12 mm thick monocrystalline substrate, from which project 100 conductive, silicon needles sharpened to facilit...Electric Stimulation; Electrodes, Implanted; Sensory Cortex; Intracortical Electrode Array1991
23 Bernstein, Paul S.HPLC measurement of ocular carotenoid levels in human donor eyes in the lutein supplementation era.PURPOSE: A substantial proportion of the population at risk for visual loss from age-related macular degeneration consumes supplements containing high doses of lutein, but clinical studies to date have shown only modest and variable increases in macular carotenoid pigments in response to supplementa...Chromatography, High Pressure Liquid; Dietary Supplements; Tissue Donors2007-02
24 Olson, Randall J.Comparison of patient satisfaction after uncomplicated cataract surgery between the silicone AMO SI-30/40 and the acrylic Alcon MA30BA and MA60BA foldable intraocular lensesPURPOSE: To compare patient satisfaction with vision 12 months after implantation of a silicone or acrylic foldable intraocular lens (IOL). SETTING: John A. Moran Eye Center, University of Utah Medical Center, Salt Lake City, Utah, USA. METHODS: Selection criteria included patients who had uneventfu...Patient Satisfaction; Lenses, Intraocular; Silicone Elastomers; Biocompatible Materials2001-10
25 Baehr, WolfgangIdentification and light-dependent translocation of a cone-specific antigen, (Cone Arrestin) recognized by monoclonal antibody 7G6PURPOSE: To elucidate the antigen recognized by monoclonal antibody (mAb) 7G6, a widely used cone-specific marker. METHODS: 7G6 immunocytochemistry was performed on sections of human, primate, and bovine retina. The antigen was immunoprecipitated from human retinal lysates and purified with protein ...Cones (Retina); Molecular Sequence Data; Phototransduction2003
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