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1 Kriesel, John D.Miliary Tuberculosis and the postpartum stateIn 1985, a resurgence of tuberculosis began in the United States. In conjunction with this resurgence, there has been an increase in the number of atypical presentations of the disease. We recently treated a patient who had disseminated tuberculosis that became manifest in the postpartum state. Wher...Miliary tuberculosis; Postpartum1995
2 Olson, Randall J.Comparison of the effects of viscoelastic agents on clinical properties of the Unfolder lens injection systemPURPOSE: To evaluate the effect of 7 viscoelastic materials on the physical properties of the Unfolder lens injection system. SETTING: John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA. METHODS: New sterile SI-40NB intraocular lenses (IOLs) were loaded into t...Lenses, Intraocular; Materials Testing; Hyaluronic Acid; Equipment Failure Analysis1999-07
3 Baehr, WolfgangNovel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD)PURPOSE: To elucidate the phenotypic and biochemical characteristics of a novel mutation associated with autosomal dominant cone-rod dystrophy (adCORD). METHODS: Twenty-three family members of a CORD pedigree underwent clinical examinations, including visual acuity tests, standardized full-field ERG...Polymorphism, Single-Stranded Conformational; Guanylate Cyclase-Activating Proteins; DNA Mutational Analysis2005
4 Digre, Kathleen B.; Mamalis, Nick; White, George L. Jr.Congenital anomalies of the optic nerve in one family.We present three cases of congenital optic disc anomalies in one family who underwent an extensive diagnostic workup to exclude any intracranial pathology. One patient had elevated optic nerve heads and was hospitalized for multiple diagnostic tests including a lumbar puncture and magnetic resonance...Optic Nerve; Congenital Anomalies1992-04-24
5 Baehr, WolfgangMetabolism and transactivation activity of 13,14-dihydroretinoic acidThe metabolism of vitamin A is a highly regulated process that generates essential mediators involved in the development, cellular differentiation, immunity, and vision of vertebrates. Retinol saturase converts all-trans-retinol to all-trans-13,14-dihydroretinol (Moise, A. R., Kuksa, V., Imanishi, Y...Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Retinoid X Receptors2005
6 Durney, Carl H.A computer graphics method for solving transcendental equationsThere are a number of ways to determine the values of x which satisfy the equation F(x)=0. (The case of interest here is that in which F i s a complex function of the complex variable x.) One way is to search for values of x which make Real (F(x)) and Imaginary (F(x)) both zero at the same time wher...Transcendental equations1970
7 Olson, Randall J.Mathematical description of causative factors and prevention of elevated intraocular pressure after keratoplastyIn keratoplasty with grafts the same size as the recipient bed, tight sutures and thick recipient corneal periphery distort the angle and may collapse the filtering meshwork. This can cause very high postoperative pressures, which can be avoided by the use of donor grafts larger than the recipient b...Keratoplasty; Trabecular Collapse; Angle Disrottion; Elevated Pressure; Aphakia; Mathematics1977-12
8 Baehr, Wolfgang; Prestwich, Glenn D.Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding proteinBovine PDEdelta was originally copurified with rod cGMP phosphodiesterase (PDE) and shown to interact with prenylated, carboxymethylated C-terminal Cys residues. Other studies showed that PDEdelta can interact with several small GTPases including Rab13, Ras, Rap, and Rho6, all of which are prenylate...Fluorescence Resonance Energy Transfer; GTP Phosphohydrolases; Immunohistochemistry2004
9 Normann, Richard A.Oscillations in rod and horizontal cell membrane potential: evidence for feed-back to rods in the vertebrate retina1. Rods and horizontal cells were studied with intracellular recordings in the retina of the toad, Bufo marinus; 161 cells were from the eyecup preparation and thirty were from the isolated perfused retina. 2. Of these cells, 39% exhibited either transient or sustained oscillations of membrane poten...Retina; Photoreceptors; Toads; Adaptation, Ocular1976
10 Baehr, Wolfgang; Katz, Bradley J.; Creel, Donnell J.; Zhang, KangAutosomal dominant cone dystrophy caused by a novel mutation in the GCAP1 gene (GUCA1A)PURPOSE: To describe the clinical features and genetic analysis of a family with an autosomal dominant cone dystrophy (adCD). METHODS: Selected members of a family with an autosomal dominant cone dystrophy underwent ophthalmic evaluation. Blood samples were obtained, genomic DNA was isolated, and ge...Mutation, Missense; DNA Mutational Analysis; Electroretinography2005
11 Frederick, Jeanne M.Inactivity of human β,β-carotene-9′, 10-′dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigmentThe macula of the primate retina uniquely concentrates high amounts of the xanthophyll carotenoids lutein, zeaxanthin, and meso-zeaxanthin, but the underlying biochemical mechanisms for this spatial- and species-specific localization have not been fully elucidated. For example, despite abundant reti...2014-01-01
12 Normann, Richard A.Acute human brain responses to intracortical microelectrode arrays: challenges and future prospectsThe emerging field of neuroprosthetics is focused on the development of new therapeutic interventions that will be able to restore some lost neural function by selective electrical stimulation or by harnessing activity recorded from populations of neurons. As more and more patients benefit from thes...2014-01-01
13 Baehr, WolfgangTissue-specific expression in transgenic mice directed by the 5'-flanking sequences of the human gene encoding interphotoreceptor retinoid-binding proteinInterphotoreceptor retinoid-binding protein (IRBP) is an extracellular protein that has been suggested to participate in the visual process as a carrier for visual retinoids. A chimeric gene composed of the human IRBP promoter fused to the bacterial reporter gene chloramphenicol acetyltransferase (C...Restriction Mapping; Nucleic Acid Hybridization; Mice; Gene Expression1990-05-25
14 Olson, Randall J.Legacy AdvanTec and Sovereign WhiteStar: a wound temperature studyPURPOSE: To assess the wound temperature of the Sovereign WhiteStar (S-WS) (AMO) and Legacy AdvanTec (L-ADV) (Alcon) phacoemulsification systems. SETTING: John A. Moran Eye Center, Health Sciences Center, University of Utah, Salt Lake City, Utah, USA. METHODS: Phacoemulsification using 20-gauge, 30-...Eye Burns; Wound Temperature; Phacoemulsification Systems2004-05
15 Bernstein, Paul S.; Zabriskie, Norman A.; Zhang, Kang; Leppert, Mark F.Diverse macular dystrophy phenotype caused by a novel complex mutation in the ELOVL4 genePURPOSE: A 5-bp deletion in ELOVL4, a photoreceptor-specific gene, has been associated with autosomal dominant (ad) macular dystrophy phenotypes in five related families, in which phenotypes range from Stargardt-like macular dystrophy (STGD3; Mendelian Inheritance in Man 600110) to pattern dystrophy...Linkage (Genetics); Middle Aged; Phenotype2001
16 Baehr, WolfgangNoninvasive two-photon imaging reveals retinyl ester storage structures in the eyeVisual sensation in vertebrates is triggered when light strikes retinal photoreceptor cells causing photoisomerization of the rhodopsin chromophore 11-cis-retinal to all-trans-retinal. The regeneration of preillumination conditions of the photoreceptor cells requires formation of 11-cis-retinal in t...Microscopy, Fluorescence; Visual Perception; Membrane Proteins2004
17 Baehr, WolfgangEvaluation of the 17 kda prenyl binding protein as a regulatory protein for phototransduction in retinal photoreceptorsThe mammalian rod photoreceptor phosphodiesterase (PDE6) holoenzyme is isolated in both a membrane-associated and a soluble form. Membrane binding is a consequence of prenylation of PDE6 catalytic subunits, whereas soluble PDE6 is purified with a 17-kDa prenyl-binding protein (PDEdelta) tightly boun...Amino Acid Sequence; Immunohistochemistry; Phosphoric Diester Hydrolases2005
18 Normann, Richard A.; Shah, Maulik R.Study of printed spiral coils for neuroprosthetic transcranial telemetry applicationsWe have explored the use of printed spiral coils (PSC's) for neuroprosthetic transcranial telemetry applications. We fabricated two-dimensional PSC's on a thin (25 microns) polyimide substrate using copper (35 microns) as a conducting material. All the coils had a fixed inner diameter of 1.0 cm. We ...Blindness; Neuroprosthesis; Transcranial Telemetry System; Prosthesis Design1998
19 Digre, Kathleen B.; Gouw, Launce G.; Harris, Catherine P.; Haines, John H.; Ptacek, L.J.Autosomal dominant cerebellar ataxia with retinal degeneration: clinical, neuropathologic, and genetic analysis of a large kindred.The autosomal dominant cerebellar ataxias (ADCA) comprise a heterogeneous group of neurologic disorders characterized by degeneration of the cerebellum, spinal cord, and brainstem. Genetic analysis has revealed two loci, SCA1 on chromosome 6p, and SCA2 on chromosome 12q, responsible for some ADCA. W...Retinal Degeneration; Cerebellar Ataxia; Genetic Analysis1994-08
20 Bernstein, Paul S.Evaluation of the G protein coupled receptor-75 (GPR75) in age related macular degeneration2001
21 Bernstein, Paul S.Biochemical characterization of the retinoid isomerase system of the eyeWe have previously shown that membranes from the retinal pigment epithelium can transform added all-trans-retinol into a mixture of 11-cis-retinoids, demonstrating the "missing reaction" in the visual cycle for the first time (Bernstein, P. S., Law, W. C., and Rando, R. R. (1987) Proc. Natl. Acad. S...Hydrogen-Ion Concentration1987
22 Olson, Randall J.Update on a long-term, prospective study of capsulotomy and retinal detachment rates after cataract surgeryPURPOSE: To evaluate the retinal detachment risks and neodymium:YAG (Nd:YAG) capsulotomy rates associated with different cataract approaches and intraocular lens (IOL) styles in a long-term,prospective clinical study. SETTING: Clinical practice of 1 ophthalmologist, Fort Collins, Colorado, USA. METH...Cataract Extraction; Laser Therapy; Retinal Detachment; Risk Factors2000-07
23 Digre, Kathleen B.; Kleinschmidt, Julia J.; Hanover, RitaIdiopathic intracranial hypertension. Relationship to depression, anxiety, and quality of lifeOBJECTIVE: To explore the incidence of depression and anxiety and to measure quality of life in women with idiopathic intracranial hypertension (IIH), a matched group cross-sectional study was conducted. Women with IIH (n = 28) were compared with control groups of weight- and age-matched women not d...Intracranial Hypertension; Depression; Anxiety; Quality of Life2000-01-25
24 Baehr, Wolfgang; Frederick, Jeanne M.; Church-Kopish, Jill; Howes, KimberlyMutant rhodopsin transgene expression on a null backgroundPURPOSE. To study mechanisms leading to photoreceptor degeneration in mouse models for autosomal dominant retinitis pigmentosa (adRP) based on the rhodopsin P23H mutation. METHODS. Mice of a transgenic line expressing a rhodopsin triple mutant, V20G, P23H, and P27L (GHL), were mated with rhodopsin (...Mutant Rhodopsin; Photoreceptor Degeneration; Autosomal Dominant Retinitis Pigmentosa; Rhodopsin2001-03
25 Askew, Eldon W.; Bernstein, Paul S.Serum and macular responses to antioxidant supplementation verus a carotenoid-rich dietary intervention in the elderly.The aim of this study was to observe responses of serum antioxidants, oxidative stress biomarkers, and macular carotenoid pigments to antioxidant supplements or dietary intervention in a single-masked, randomized, pilot clinical study of elderly subjects receiving antioxidant supplements or a dietar...Macula; Serum Carotenoids; Zeaxanthin2006-02-01
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