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1 Bernstein, Paul S.HPLC measurement of ocular carotenoid levels in human donor eyes in the lutein supplementation era.PURPOSE: A substantial proportion of the population at risk for visual loss from age-related macular degeneration consumes supplements containing high doses of lutein, but clinical studies to date have shown only modest and variable increases in macular carotenoid pigments in response to supplementa...Chromatography, High Pressure Liquid; Dietary Supplements; Tissue Donors2007-02
2 Digre, Kathleen B.; Warner, Judith E. A.; Bernstein, Paul S.; Alder, Stephen C.Vitamin A in the cerebrospinal fluid of patients with and without idiopathic intracranial hypertensionWe quantified vitamin A in the cerebrospinal fluid of patients with idiopathic intracranial hypertension, elevated intracranial pressure of other causes and normal intracranial pressure. Vitamin A could be detected by high-pressure liquid chromatography in most of the specimens. There was a signific...Chromatography, High Pressure Liquid; Headache2002-11
3 Bernstein, Paul S.; Gellermann, WernerNonmydriatic fluorescence-based quantitative imaging of human macular pigment distributions.We have developed a CCD-camera-based nonmydriatic instrument that detects fluorescence from retinal lipofuscin chromophores ("autofluorescence") as a means to indirectly quantify and spatially image the distribution of macular pigment (MP). The lipofuscin fluorescence intensity is reduced at all ret...Cytology; Sensitivity and Specificity2006-10
4 Frederick, Jeanne M.; Thulin, Craig; Bernstein, Paul S.Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eyeUptake, metabolism, and stabilization of xanthophyll carotenoids in the retina are thought to be mediated by specific xanthophyll-binding proteins (XBPs). A membrane-associated XBP was purified from human macula using ion-exchange chromatography followed by gel-exclusion chromatography. Two-dimensio...Circular Dichroism; Isoelectric Focusing; Macula Lutea; Xanthophylls2004
5 Baehr, Wolfgang; Prestwich, Glenn D.Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding proteinBovine PDEdelta was originally copurified with rod cGMP phosphodiesterase (PDE) and shown to interact with prenylated, carboxymethylated C-terminal Cys residues. Other studies showed that PDEdelta can interact with several small GTPases including Rab13, Ras, Rap, and Rho6, all of which are prenylate...Fluorescence Resonance Energy Transfer; GTP Phosphohydrolases; Immunohistochemistry2004
6 Askew, Eldon W.; Bernstein, Paul S.Serum and macular responses to antioxidant supplementation verus a carotenoid-rich dietary intervention in the elderly.The aim of this study was to observe responses of serum antioxidants, oxidative stress biomarkers, and macular carotenoid pigments to antioxidant supplements or dietary intervention in a single-masked, randomized, pilot clinical study of elderly subjects receiving antioxidant supplements or a dietar...Macula; Serum Carotenoids; Zeaxanthin2006-02-01
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